Patents Assigned to Biorganica LTDA.
  • Stable pharmaceutical compositions with docetaxel
    Patent number: 8304450
    Abstract: The invention relates to pharmaceutical compositions comprising anhydrous(2R,3S)4-acetoxy-2-a-benzoyloxy-5?-20-epoxy-1,7-?-10-?-tri-hydroxy-9-oxo-tax-11-en-13?-il 3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate (I)(docetaxel) and 4-acetoxy-2-?-benzoyloxy-5-?-20-epoxy-1,7?-10-?-tri-hydroxy-9-oxo-tax-11-en-13?-il (2R,3S)3-benzoylamino-2-hydroxy-3-phenylpropionate (II) (paclitaxel), methods for treating neoplastic tumors using anhydrous docetaxel and paclitaxel, and a process for the preparation of the anhydrous docetaxel and paclitaxel.
    Type: Grant
    Filed: August 7, 2008
    Date of Patent: November 6, 2012
    Assignees: Quiral Quimica Do Brasil S.A., Biorganica Ltda.
    Inventors: Marco Antônio Santini, Antônio Machado, Aurélio Maranduba, Eneida Guimarães, Marcio Santiago Junior, Maria Silva
  • Process for the preparation of concentrated, sterile injectable solutions containing docetaxel
    Patent number: 7838551
    Abstract: This invention describes a process for the production of ANHYDROUS active pharmaceutical ingredients (APIs); a process for the preparation of HYDRATED active pharmaceutical ingredients, a process for the preparation of sterile and stable injectable solutions, and their use, more specifically, APIs which are taxane derivatives, especially (2R,3S) 4-acetoxy-2-?-benzoyloxy-5?-20-epoxy-1,7-?-10-?-tri-hydroxy-9-oxo-tax-11-en-13?-il 3-tert-butoxy carbonylamino-2-hydroxy-3-phenylpropionate (I); 4-acetoxy-2-?-benzoyloxy-5-?-20-epoxy-1,7?-10-?-tri-hidroxy-9-oxo-tax-11-en-13?-il (2R,3S) 3-benzoylamino-2-hydroxy-3-phenylpropionate (II), and particularly 4-acetoxy-2-?-benzoyloxy-5?-20-epoxy-1, 7-?-10-?-tri-hidroxy-9-oxo-tax-11-en-13?-il (2R,3S) 3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate tri-hydrate (III).
    Type: Grant
    Filed: December 10, 2004
    Date of Patent: November 23, 2010
    Assignees: Quiral Quimica do Basil S.A., Biorganica LTDA.
    Inventors: Marco Antônio Santini, Antônio Machado, Aurélio Maranduba, Eneida Guimarães, Marcio Santiago Junior, Maria Silva
  • PHARMACEUTICAL COMPOSITIONS CONTAINING DOCETAXEL AND A DEGRADATION INHIBITOR AND A PROCESS FOR OBTAINING THE SAME
    Publication number: 20090221688
    Abstract: Pharmaceutical compositions containing polysorbate 80, anhydrous docetaxel (I) or its trihydrate and an organic acid with a pKa between 2.5-4.5 employed as a degradation inhibitor.
    Type: Application
    Filed: February 9, 2006
    Publication date: September 3, 2009
    Applicants: Quiral Quimica DO Brasil S.A., Biorganica Ltda.
    Inventors: Antonio Machado, Aurelio Maranduba, Eneida Guimaraes, Livia Machado, Marcio Santiago, JR., Maria Silva
  • PROCESS FOR THE PREPARATION OF ANHYDROUS AND HYDRATED ACTIVE PHARMACEUTICAL INGREDIENTS (APIS); STABLE PHARMACEUTICAL COMPOSITIONS PREPARED FROM THE SAME AND USES OF SAID COMPOSITIONS
    Publication number: 20090069409
    Abstract: The invention relates to pharmaceutical compositions comprising anhydrous(2R,3S)4-acetoxy-2-a-benzoyloxy-5?-20-epoxy-1,7-?-10-?-tri-hydroxy-9-oxo-tax-11-en-13?-il 3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate (I)(docetaxel) and 4-acetoxy-2-?-benzoyloxy-5-?-20-epoxy-1,7?-10-?-tri-hydroxy-9-oxo-tax-11-en-13?-il (2R, 3S)3-benzoylamino-2-hydroxy-3-phenylpropionate (II) (paclitaxel), methods for treating neoplastic tumors using anhydrous docetaxel and paclitaxel, and a process for the preparation of the anhydrous docetaxel and paclitaxel.
    Type: Application
    Filed: August 7, 2008
    Publication date: March 12, 2009
    Applicants: QUIRAL QUIMICA DO BRASIL, BIORGANICA LTDA.
    Inventors: Marco Antonio SANTINI, Antonio Machado, Aurelio Maranduba, Eneida Guimaraes, Marcio Santiago Junior, Maria Silva
  • Process For The Preparation Of Anhydrous And Hydrated Active Pharmaceutical Ingredients (Apis); Stable Pharmaceutical Compositions Prepared From The Same And Uses Of Said Compositions
    Publication number: 20080051450
    Abstract: This invention describes a process for the production of ANHYDROUS active pharmaceutical ingredients (APIs); a process for the preparation of HYDRATED active pharmaceutical ingredients, a process for the preparation of sterile and stable injectable solutions, and their use, more specifically, APIs which are taxane derivatives, especially (2R,3S) 4-acetoxy-2-?-benzoyloxy-5?-20-epoxy-1,7-?-10-?-tri-hydroxy-9-oxo-tax-11-en-13?-il 3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate (I); 4-acetoxy-2-?-benzoyloxy-5-?-20-epoxy-1, 7?-10-?-tri-hidroxy-9-oxo-tax-11-en-13?-il (2R,3S) 3-benzoylamino-2-hydroxy-3-phenylpropionate (II), and particularly 4-acetoxy-2-?-benzoyloxy-5?-20-epoxy-1,7-?-10-?-tri-hidroxy-9-oxo-tax-11-en-13?-il (2R,3S) 3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate tri-hydrate (III).
    Type: Application
    Filed: December 10, 2004
    Publication date: February 28, 2008
    Applicant: BIORGANICA LTDA.
    Inventors: Marco Antonio Santini, Antonio Machado, Aurelio Maranduba, Eneida Guimaraes, Marcio Santiago, Maria Silva