Abstract: The invention provides a tablet that contains free-form arginine at a high content, suppresses cracking and collapse due to moisture absorption, is superior in preservation stability and permits convenient production. The tablet contains free-form arginine at a concentration of not less than 5 mass % of the total amount of the tablet and can be obtained by compression molding free-form arginine dried by a spray dry method.
Abstract: An objection of the present invention is to provide an agent for preventing or improving decline in brain function such as decreased perception ability, decreased memory learning ability, decreased thinking ability, decreased concentration, decreased attention, decreased judgment ability, depression, and decreased exercise performance caused thereby. According to the present invention, an agent for protecting brain neuronal cells, comprising citrulline or a salt thereof and citicoline or a salt thereof as active ingredients as well as an agent for preventing or improving decline in brain function, comprising citrulline or a salt thereof and citicoline or a salt thereof as active ingredients is provided.
Type:
Grant
Filed:
October 30, 2013
Date of Patent:
February 2, 2021
Assignee:
KYOWA HAKKO BIO CO., LTD.
Inventors:
Kota Kumagai, Masahiko Morita, Takahiro Hara, Kohji Fukunaga
Abstract: A composition for a FDM 3D printer is disclosed. The composition contains bioglass and a biocompatible polymer resin. In addition, a FDM 3D printer molded article having a laminated strut structure, in which the composition for the FDM 3D printer is injected into four layers, is disclosed.
Type:
Application
Filed:
December 11, 2019
Publication date:
January 28, 2021
Applicants:
CG Bio Co., Ltd., BIOALPHA CORPORATION
Inventors:
Jun Young LIM, Yong Bok KIM, Hyun Seung RYU
Abstract: The present invention relates to a wound volume measuring method and device, wherein the method comprises the steps of: disposing a foam dressing on a wound site; hermetically sealing the wound site by attaching a film dressing on skin adjacent to the wound site; supplying a negative pressure to the hermetically sealed space formed between the film dressing and the wound site, and thereby discharging fluid into the hermetically sealed space; measuring the flow of the fluid discharged from the hermetically sealed space; and calculating the volume of the wound site on the basis of the measured fluid flow.
Type:
Grant
Filed:
January 19, 2016
Date of Patent:
January 5, 2021
Assignee:
CG Bio Co., Ltd.
Inventors:
Hyun Seung Ryu, Joon Pio Hong, Jun Hyuk Seo, Hee Jun Park, Soon Gee Hong, Kang Jin Jeon, Hoon Kim
Abstract: According to the present invention, a crystal of reduced glutathione having a reduced content of impurities, particularly L-cysteinyl-L-glycine and a method for producing the same are provided. The present invention relates to a crystal of reduced glutathione, wherein, in a high-performance liquid chromatography (HPLC) analysis, the peak area of L-cysteinyl-L-glycine is 0.02 or less with respect to the peak area of reduced glutathione which is taken as 100.
Abstract: The present invention provides a crystal of reduced glutathione having excellent powder properties and a method for producing the same. The present invention relates to a crystal of reduced glutathione, wherein the average crystal thickness is 10 ?m or more.
Abstract: The present invention provides a crystal of reduced glutathione having excellent powder properties and a method for producing the same. The present invention relates to a crystal of reduced glutathione, wherein the average crystal thickness is 10 ?m or more.
Abstract: An object of the present invention is to provide a crystal of 6?-sialyllactose (hereinafter, referred to as 6SL) sodium salt, which is easily handled, and has high storage stability at normal temperature as well as under high temperature conditions, and provide a production process thereof. The present invention relates to a crystal of 6SL sodium salt and a process for producing the crystal.
Abstract: The present invention relates to a zinc-alpha-2-glycoprotein (ZAG) protein-derived peptide and a use thereof. The ZAG protein-derived peptide according to the present invention shows an expression reducing effect of various immune factors shown in acute or chronic atopic dermatitis, and has a decreased immune response and decreased IgE expression and thus may be used to prevent, treat or improve xeroderma or an abnormal skin barrier function such as atopic dermatitis, an allergic disease or inflammation.
Type:
Application
Filed:
September 28, 2018
Publication date:
August 6, 2020
Applicant:
L&C Bio Co., LTD.
Inventors:
Eun Seong LEE, Hyung Gu KIM, Whan Chul LEE, Kee Won LEE
Abstract: The present application discloses a method for treating a protein deficiency in the central nervous system of a subject in need thereof, comprising systemically administering to the subject a therapeutically effective dose of a fusion polypeptide comprising the first protein, wherein the fusion polypeptide comprises: (a) the first protein; (b) a second protein that provides extended circulation-lifetime in vivo and (c) blood brain barrier crossing facilitating peptide; wherein the fusion polypeptide crosses the blood brain barrier (BBB).
Type:
Application
Filed:
August 30, 2019
Publication date:
July 23, 2020
Applicant:
L & J Bio Co., Ltd.
Inventors:
Sookhee Bang, Jeong Kuen Song, Seung-Wook Shin, Kwan Hee Lee, Ho June Lee
Abstract: Two long-acting recombinant porcine FSH (follicle-stimulating hormone) fusion proteins, comprising pFSH-Fc-1 and pFSH-Fc-2. ? subunit/? subunit is directly or indirectly fused on a Fc fragment by means of a linking component; the ? subunit/? subunit is combined with the ? subunit/? subunit by means of a Van der Waals force or the linking component. The porcine FSH fusion proteins can be prepared by an eukaryotic expression system based on a gene engineering technology. The two porcine FSH fusion proteins have a good medicinal effect and have a longer half-life period as compared with that of a natural porcine FSH; the two porcine FSH fusion proteins do not generate an undesirable effect on animals and can replace pregnant mare serum gonadotropin (PMSG) to be used in animal breeding production. The two porcine FSH fusion proteins can be used for preparation of medicines in the field of animal breeding.
Abstract: Provided are a method of manufacturing a hyaluronate-coated high-functional suture and a high-functional suture manufactured thereby, and more particularly to a method of manufacturing a high-functional suture and a high-functional suture manufactured thereby, wherein a suture for internal and external surgery derived from a conventional chemical synthetic material is coated with a hyaluronate as a biocompatible material, thus improving biocompatibility, functionality and ease of use.
Abstract: Disclosed are a cervical vertebra fixation device using a plurality of screws characterized by comprising: a body having a length extending across at least two bones and including a first end and a second end opposite to the first end; and three or more openings formed in the body for receiving the plurality of screws, wherein the first end has a profile with at least a portion of the body being removed with respect to the horizontal line perpendicular to the length direction to prevent adjacent segment degeneration, and a cervical vertebra fixation device using at least one screw, comprising: a body fixed into a bone; at least one opening formed in the body for receiving the at least one screw; a cover for preventing any escape of the screws inserted; and a cover screw, wherein the cover is movable with respect to the body to allow the insertion of screws while the cover is coupled to the body.
Type:
Grant
Filed:
April 8, 2016
Date of Patent:
June 9, 2020
Assignee:
CG BIO CO., LTD.
Inventors:
Jun Hyuk Seo, Dong Ryul Song, Myoung Lae Jo, Hae Jun Jeong, Eugene Yeom
Abstract: The present invention relates to a composition for treating benign prostatic hyperplasia and a health functional food, containing an extract of Aucklandiae Radix and costunolide as active ingredients.
Type:
Application
Filed:
August 22, 2017
Publication date:
June 4, 2020
Applicant:
QUBEST BIO CO., LTD.
Inventors:
Kyung-Jae KIM, Young-Cheon SONG, Hyun-Seok KONG, Jin-Man KIM
Abstract: The present invention relates to a composition for detecting microbial contamination comprising a preparation for detecting nucleases, and a use thereof. A probe for measuring nucleic acid double-stranded nucleases, according to the present invention, may detect the comprehensive nucleic acid degradation capability of nucleases, whereby it is possible to quickly and precisely detect and quantify live microorganisms in a sample in a simple manner. Moreover, since the probe of the present invention is characterized in that signals of fluorescence consistently increase; is capable of measuring live microorganisms; and consists of a double-stranded nucleic acid, the probe is excellent for storage in a kit or a cartridge. As such, it is expected that the probe of the present invention may be used to easily and simply measure and compare the degree of contamination of microorganisms in an environment.
Type:
Grant
Filed:
April 7, 2016
Date of Patent:
May 26, 2020
Assignee:
Haesung Bio Co., Ltd.
Inventors:
Kyoung Sook Park, Bong Hyun Chung, Kyung Jin Lee, Byung Kwon Kim, So Yeon Yi, Jung Sun Kwon, Ui Jin Lee, Seong U. Kim, Ho Jae Lee
Abstract: The present invention provides a crystal of a monovalent cation salt of 3-hydroxyisovaleric acid (hereinafter, referred to as HMB), which is excellent in solubility and easy to handle, and a process for producing the crystal. A crystal of a monovalent cation salt of HMB is precipitated in an aqueous HMB solution containing a monovalent cation-containing compound and having a pH of 4.0 to 9.0, and the crystal of a monovalent cation salt of HMB is thereafter collected from the aqueous solution.
Type:
Grant
Filed:
November 18, 2016
Date of Patent:
May 12, 2020
Assignees:
KYOWA HAKKO BIO CO., LTD., OTSUKA PHARMACEUTICAL FACTORY, INC.
Abstract: The present invention provides a crystal of reduced glutathione that is stable, and is easy to process, and a method for producing the crystal. According to the present invention, a crystal of a metal salt of reduced glutathione is produced by suspending an amorphous solid of a metal salt of reduced glutathione in a hydrophobic organic solvent, and adding water to the resulting suspension to precipitate a crystal of a metal salt of reduced glutathione.
Type:
Grant
Filed:
March 31, 2016
Date of Patent:
May 5, 2020
Assignees:
University Public Corporation Osaka, Kyowa Hakko Bio Co., Ltd.
Abstract: According to the present invention, theanine can efficiently be produced without exogenously adding ethylamine and without accumulation or leftover of ethylamine as a byproduct, by using a microorganism having enhanced activity to produce ethylamine with acetaldehyde and alanine as substrates and having enhanced activity of ?-glutamylmethylamide synthetase or glutaminase.
Abstract: The present invention relates to a probe for detecting bacteria using a peptidoglycan-binding protein, and a method for preparing the same. Also, the present invention relates to a method for detecting bacteria using the probe. The probe for detecting bacteria according to the present invention can specifically detect bacteria. That is, the probe according to the present invention can clearly distinguish between yeast and bacteria and can detect both Gram-negative and Gram-positive bacteria, and thus is expected to be usable in various fields as a universal probe for detecting bacteria. Further, use of the probe allows bacteria to be detected by identifying only fluorescence development without an additional enzymatic treatment, thereby enabling a simple and quick bacterial detection. In particular, the probe is expected to be effectively usable in the food industry where quick bacterial detection is required.
Type:
Grant
Filed:
April 7, 2016
Date of Patent:
April 28, 2020
Assignee:
Haesung Bio Co., Ltd.
Inventors:
Bong Hyun Chung, Eun Kyung Lim, Kyoung Sook Park, Jong Min Choi, Seong U. Kim, Heejun Lee
Abstract: A hybrid stent includes multiple main cells aligned in a spiral shape and including multiple first link units which are aligned diagonally and spaced at a predetermined distance from each other and multiple second link units which connect adjacent first link units among the multiple first link units and are spaced at a predetermined distance from each other, and one or more open cells adjacent to the multiple main cells in a longitudinal direction and aligned in a spiral shape.
Type:
Grant
Filed:
September 21, 2015
Date of Patent:
April 21, 2020
Assignees:
CG BIO CO., LTD., THE ASAN FOUNDATION
Inventors:
Han Ki Kim, Hyun Seung Ryu, Jun Hyuk Seo, Jun Kyu Park, Seok Beom Song, Chang Hun Kum, Jae Hwa Cho, Gyu Hyun Jin, Deok Hee Lee, Seon Moon Hwang, Tae Il Kim, Ok Kyun Lim, Ga Young Lee