Patents Assigned to Bios Inc.
  • SMALL MOLECULE PROTEIN SYNTHESIS MODULATORS
    Publication number: 20250091989
    Abstract: The present disclosure provides compounds of the formulae herein (e.g., Formula (I)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.
    Type: Application
    Filed: September 19, 2024
    Publication date: March 20, 2025
    Applicant: Interdict Bio, Inc.
    Inventors: David Gygi, Sogole Sami Bahmanyar, Lawrence Hamann
  • Anti-BCMA antibody and use thereof
    Patent number: 12252541
    Abstract: Provided are an antibody or antigen-binding fragment thereof that specifically binds to a B-cell maturation antigen (BCMA), a method of preparing the same, and use thereof. Accordingly, these can be utilized in effectively preventing or treating cancers.
    Type: Grant
    Filed: June 26, 2019
    Date of Patent: March 18, 2025
    Assignee: ABL BIO INC.
    Inventors: Kyungjin Park, Hyejin Chung, Kyeongsu Park, Yangsoon Lee, Mikyung Chang, Jaehyoung Jeon, Youngkwang Kim, Junhyun Jeong, Jiseon Yoo, Yeunju Kim, Donghoon Yeom, Eunjung Kim, Bora Lee, Jinwon Jung
  • ORGANISMS AND METHODS OF USE THEREOF
    Publication number: 20250084445
    Abstract: Disclosed are organisms comprising a highly expressed form of EC 1.2.3.1, and methods of their use including methods for efficient fermentation broth recycle, methods for improving bottoms recycle, methods for converting CO, CO2, and optionally H2 to ethanol and other oxygenated products, methods for preparing animal feed, and methods for preparing fertilizer.
    Type: Application
    Filed: January 11, 2023
    Publication date: March 13, 2025
    Applicant: SYNATA BIO, INC.
    Inventors: David Harvey KEATING, Matthew Theodore KISSINGER
  • ANTIBODY-DRUG CONJUGATE
    Publication number: 20250082772
    Abstract: Problem: The present invention provides an antibody-drug conjugate (ADC). The present invention also provides a conjugate of an anti-CD71 antibody or an antigen-binding fragment thereof with a drug. The present invention further provides a conjugate of Fab? with a drug. The present invention further provides a composition comprising the conjugate for delivering the drug to a tissue or a cell of muscle or the like. Solution: A conjugate of an anti-CD71 antibody or an antigen-binding fragment thereof with a drug, and a conjugate of Fab? of an antibody with a drug.
    Type: Application
    Filed: April 16, 2024
    Publication date: March 13, 2025
    Applicant: GENAHEAD BIO, INC.
    Inventors: Tsukasa SUGO, Kenichi MIYATA, Tetsuya OHTAKI
  • ANTI-CLL-1 ANTIBODIES AND USES THEREOF
    Publication number: 20250084158
    Abstract: Provided are anti-CLL-1 antibodies and uses thereof, according to the anti-CLL-1 antibody of one aspect, it can bind to CLL-1 with high binding affinity, and can cause activation of T cells, thus it can be used effectively for preventing or treating the cancer expressing CLL-1.
    Type: Application
    Filed: July 20, 2022
    Publication date: March 13, 2025
    Applicant: ABL BIO INC.
    Inventors: Eunsil SUNG, Junga KWON, Youngkwang KIM, Juhee KIM, Kyungjin PARK, Sumyeong PARK, Byungje SUNG, Byeongmin YOO, Bora LEE, Suyoun LEE, Shinai LEE, Yangsoon LEE, Eunhee LEE, Yangmi LIM, Jaehyoung JEON, Jinwon JUNG
  • FERMENTATION METHODS USING ACETOGENIC CARBOXYDOTROPHIC BACTERIA
    Publication number: 20250084444
    Abstract: Disclosed are methods for producing from a gaseous substrate comprising CO, CO2, and optionally H2 at least one oxygenated product. Also provided are methods of using a broth deficient in thiamine or thiazole-containing thiamine precursors as a screening tool for suitable ethanol producing acetogenic carboxydotrophic bacteria strains, operating a syngas fermentation without the addition of thiamine or thiazole-containing thiamine precursors, controlling bacterial contamination in a bioreactor, and methods for preparing animal feed and fertilizer.
    Type: Application
    Filed: January 11, 2023
    Publication date: March 13, 2025
    Applicant: SYNATA BIO, INC.
    Inventors: David KEATING, Jennine B. TERRILL
  • Ribonucleic acids with 4?-thio-modified nucleotides and related methods
    Patent number: 12247046
    Abstract: Disclosed are messenger RNA molecules and related compositions incorporating a 4?-thio modification in the furanose ring of at least one nucleotide residue, and methods of using these mRNAs to produce an encoded therapeutic protein in vivo and to treat or prevent diseases or disorders. In certain embodiments, the 4?-thio modified mRNA provides for enhanced stability and/or reduced immunogenicity in in vivo therapies.
    Type: Grant
    Filed: August 10, 2022
    Date of Patent: March 11, 2025
    Assignee: Translate Bio, Inc.
    Inventors: Frank DeRosa, Michael Heartlein
  • Replication stress pathway agent compositions and methods for treating cancer
    Patent number: 12246017
    Abstract: Provided herein are methods of treating cancer in a subject, wherein the cancer is extrachromosomal DNA-positive (ecDNA-positive) or therapeutically resistant, the method comprising administering to the subject a therapeutically effective amount of a replication stress (RS) pathway agent alone or in combination with a targeted therapeutic.
    Type: Grant
    Filed: March 24, 2023
    Date of Patent: March 11, 2025
    Assignee: BOUNDLESS BIO, INC.
    Inventors: Christian Hassig, Ryan Hansen, Snezana Milutinovic, Jason Christiansen, Zachary D. Hornby, Sudhir Chowdhry, Anthony Celeste, Kristen Turner, Deepti Wilkinson
  • Anti-BCMA CAR antibodies, conjugates, and methods of use
    Patent number: 12247084
    Abstract: The invention provides improved methods for detecting anti-BCMA CAR expression on T cells.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: March 11, 2025
    Assignee: 2seventy bio, Inc.
    Inventors: Kevin Friedman, Molly Reed Perkins
  • MODIFIED BIOLUMINESCENT ENZYMES
    Publication number: 20250075191
    Abstract: One or more new variant(s) of luciferases and fungal luciferin biosynthesis enzymes, nucleic acids able to encode these enzymes, and proteins able to catalyze certain stages of the fungal luciferin biosynthesis are provided herein. More specifically one or more bioluminescent enzymes, and in particular one or more hispidin hydroxylases and luciferases, and functional fragments thereof and nucleic acids encoding them are disclosed.
    Type: Application
    Filed: August 27, 2024
    Publication date: March 6, 2025
    Applicant: Light Bio, Inc.
    Inventors: Lance P. Encell, Mary P. Hall, Trish T. Hoang, Keith V. Wood, Monika G. Wood, Alexander S. Mishin, Karen S. Sarkisyan, Ilia V. Yampolsky
  • Vitamin cationic lipids
    Patent number: 12240824
    Abstract: Disclosed are cationic lipids comprising a vitamin substructure and an ionizable nitrogen-containing group. Cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.
    Type: Grant
    Filed: May 29, 2019
    Date of Patent: March 4, 2025
    Assignee: TRANSLATE BIO, INC.
    Inventors: Yi Zhang, Shrirang Karve, Saswata Karmakar, Frank DeRosa, Michael Heartlein
  • Anti-HER2/anti-4-1BB bispecific antibody and use thereof
    Patent number: 12240913
    Abstract: Provided are an anti-4-1BB/anti-HER2 bispecific antibody, and a pharmaceutical composition and a method for treating and/or preventing a cancer using the same.
    Type: Grant
    Filed: July 27, 2020
    Date of Patent: March 4, 2025
    Assignees: ABL BIO INC., YUHAN CORPORATION
    Inventors: Hyejin Chung, Yeryoung Yong, Kyeongsu Park, Eunyoung Park, Ui-Jung Jung, Yangsoon Lee, Eunjung Kim, Yong-Gyu Son, Wonjun Son, Seawon Ahn, Donghoon Yeom, Chanmoo Lee, Junghyeon Hong, Moo Young Song, Eun-Jung Lee, Na Rae Lee, Young Bong Park, Eun-Jung Lee, Taewang Kim
  • Engineered leucine decarboxylases
    Patent number: 12241100
    Abstract: The present invention provides engineered leucine decarboxylase (LDC) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered leucine decarboxylase (LDC) polypeptides. In some embodiments, the engineered LDC polypeptides are optimized to provide enhanced catalytic activity, as well as reduced sensitivity to proteolysis, and/or increased tolerance to low pH environments. In some embodiments, the engineered LDC polypeptides are optimized to provide improved storage stability. The present invention also provides methods for the use of the compositions comprising the engineered LDC polypeptides for therapeutic and industrial purposes.
    Type: Grant
    Filed: February 3, 2021
    Date of Patent: March 4, 2025
    Assignee: SYNTIS BIO, INC.
    Inventors: Joyce Liu, Leann Quertinmont Teadt, Nikki Dellas, Stephan Jenne, Faye Loan Du, Kristen Jean Vallieu, Kerryn McCluskie
  • PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING MUSCLE DISEASES
    Publication number: 20250064875
    Abstract: The present disclosure relates to a pharmaceutical composition for preventing or treating muscle diseases. Particularly, an elderberry extract or a monosaccharide- and amino acid-coupled compound, according to the present disclosure exhibits the effects of inhibiting muscle cell apoptosis, inhibiting the expression of inflammatory cytokines, promoting the secretion of testosterone, inhibiting the expression of muscle atrophy markers and myostatin and causing muscle to recover in sarcopenia animal models, and thus can be effectively used in the treatment of muscle diseases.
    Type: Application
    Filed: November 10, 2022
    Publication date: February 27, 2025
    Applicant: KOSA BIO INC.
    Inventors: Hyunseok KONG, Jiyeon KIM, Seonhwa HONG, Jongsu KIM
  • Composition for oral or nasal delivery of tetanus, diphtheria, and pertussis vaccine alone or in combination using neurotoxin associated proteins
    Patent number: 12233119
    Abstract: The present invention describes a second-generation tetanus toxoid vaccine and a process for the preparation thereof, comprising the steps of: inducing an E. coli culture OD600=0.5 by adding 0.2 mM IPTG; growing the culture at 14-16° C. for 14 to 20 hours; suspending the culture in 25 mM phosphate buffer containing 200 mM sodium chloride; adding 1% of triton-X-100 to the phosphate buffer, and adding the buffer to the culture; sonicating the culture for a period of 3 minutes (at 5 sec on/off pulse) at 4° C. on cold beads; centrifuging the culture for 60 to 90 minutes; collecting and purifying a supernatant using Ni-NTA affinity column with an eluant; and combining the supernatant into a pool with contaminated bands and concentrating using Centriprep-30 centrifuge filters (30 kDa pores).
    Type: Grant
    Filed: September 14, 2023
    Date of Patent: February 25, 2025
    Assignee: Prime Bio, Inc.
    Inventor: Bal Ram Singh
  • VCN enhancer compositions and methods of using the same
    Patent number: 12234476
    Abstract: The invention provides improved gene therapy methods and compositions.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: February 25, 2025
    Assignee: BLUEBIRD BIO, INC.
    Inventors: Melissa Bonner, Olivier Negre
  • Methods for purification of messenger RNA
    Patent number: 12234446
    Abstract: The present invention provides, among other things, methods of purifying messenger RNA (mRNA) including the steps of subjecting an impure preparation comprising in vitro synthesized rnRNA to a denaturing condition, and purifying the rnRNA from the impure preparation from step (a) by tangential flow filtration, wherein the mRNA purified from step (b) is substantially free of prematurely aborted RNA sequences and/or enzyme reagents used in in vitro synthesis.
    Type: Grant
    Filed: November 24, 2020
    Date of Patent: February 25, 2025
    Assignee: TRANSLATE BIO, INC.
    Inventors: Michael Heartlein, Frank DeRosa, Anusha Dias, Shrirang Karve
  • Sickled beta globin antibodies
    Patent number: 12234296
    Abstract: The invention provides anti-?S globin antibodies or antigen binding fragments thereof.
    Type: Grant
    Filed: December 22, 2022
    Date of Patent: February 25, 2025
    Assignee: bluebird bio, Inc.
    Inventor: Olivier Negre
  • Textured medical textiles
    Patent number: 12226299
    Abstract: Described herein are implants (e.g., medical textiles/biotextiles) that include stitched gripping filaments to increase gripping, and methods of forming and using them. In some configurations these apparatuses may be configured as surgical grafts that may be used for soft tissue reconstruction, regeneration, or repair.
    Type: Grant
    Filed: September 16, 2022
    Date of Patent: February 18, 2025
    Assignee: TELA Bio, Inc.
    Inventors: E. Skott Greenhalgh, John-Paul Romano, Travis Speicher, Brendan Farrell
  • Metabolic engineering for microbial production of terpenoid products
    Patent number: 12227783
    Abstract: In various aspects and embodiments, the invention relates to bacterial strains and methods for making terpene and terpenoid products. The invention provides bacterial strains with improved carbon flux through the MEP pathway, to thereby increase terpene and/or terpenoid product yield by fermentation with carbon sources such as glucose.
    Type: Grant
    Filed: April 26, 2022
    Date of Patent: February 18, 2025
    Assignee: Manus Bio Inc.
    Inventors: Ajikumar Parayil Kumaran, Chin-Giaw Lim, Souvik Ghosh, Christopher Pirie, Jason Donald, Aaron Love, Hong Nan, Hsien-Chung Tseng, Christine Nicole S. Santos, Ryan Philippe