Abstract: An engineered transcriptional modulator (ETM) comprising: (a) at least one epigenetic effector domain; operably linked to (b) an endonuclease.

Abstract: A body orifice remodeling device includes a cylindrical handpiece having a defined length which is adapted to be inserted into the body orifice and an elongated monopolar electrode mounted outside on the circumference of the cylindrical handpiece and extending substantially along the length of the handpiece. A source of radio frequency (RF) energy in the handpiece is configured to generate RF energy to the elongated monopolar electrode; and a source of electromagnetic stimulation energy (EMagS) in the handpiece is configured to generate (EMagS) energy.

Abstract: A system for cosmetically treating a patient's skin or body with one or more EMS coils and/or RF electrodes mounted on a planar holder; a hydrogel containing gel pad, the gel pad being positionable between the holder and the skin tissue; wherein the gel pad being of a material that is biocompatible and conducts RF and/or EMS energy when EMS energy is applied from the one or more EMS coils; a programmable controller to activate the one or more EMS coils; the programmable controller, after the planar holder is applied to the skin tissue, being configured to activate one or more of the plurality of EMS coils to provide treatment in the form of stimulation to the skin tissue.

Abstract: Disclosed is a lamp block comprising a lamp which is a glass tube having an internal final end and an external final end, wherein said internal final end ends with an electrode that fits directly into a connector placed on the machine into which said lamp is mounted and said external final end ends with an electrode to which a cable is connected, at least one portion of said cable being inserted in a key which is a hollow cylinder. Also disclosed is a laser apparatus suitable to house said lamp block and a method for extracting and housing said lamp block in said laser apparatus. In a preferred embodiment, said apparatus further comprise a system for electronic recognition.

Abstract: A process for producing hydroxyalkanoate copolymers, which comprises: (i) pre-treating a sucrose-containing feedstock in an acidic solution; (ii) feeding the pre-treated feedstock into a bioreactor containing polyhydroxyalkanoate producing microbial cells; (iii) cultivating the polyhydroxyalkanoate producing microbial cells to form a cell mass containing the hydroxyalkanoate copolymers; (iv) recoverying the hydroxyalkanoate copolymers from the cell mass. The pre-treating step has the main function of hydrolyzing sucrose into glucose and fructose, which in turn are converted into 4-ketovaleric acid to give a mixture of mono-saccharides and organic precursors for microbial synthesis of hydroxyalkanoate copolymers, and particularly of PHBVV ter-polymers. Complex and expensive purification processes of the substrates obtained from the pre-treating step are not needed. The solutions can be directly used as the feeding solutions for microbial PHA biosynthesis.

Abstract: The present invention relates to a process for producing biodegradable polymeric materials including polyhydroxyalkanoates (PHAs) by using the cell debris left from PHA recovery and purification. The process comprises: (a) cultivating PHA-producing microbial cells in a medium solution containing an organic carbon source to form PHAs that are accumulated in the cells as inclusion bodies; (b) harvesting the cells from the spent medium and solubilizing the non-PHA cell mass to obtain a PHA solid and a cell debris solution; (c) separating the PHA solid from the cell debris solution; (d) feeding the cell debris solution to the cultivation step (a). By reusing the cell debris generated from PHA recovery, the invention avoids disposal of a large amount of aqueous waste. In addition, a remarkable increase of cell growth and PHA synthesis is achieved, because the cell debris can be readily assimilated by the microbial cells as the nutrients.

Abstract: A body treatment apparatus comprises: a support structure; at least one footboard hanging on said support structure so as to allow at least an oscillatory movement thereof in the direction of the gravitational action; said footboard being suitable for supporting at least a part of body to be treated; means for stressing said footboard with an oscillation in the direction of the gravitational action, so that on at least said part of the body supported by said footboard, an action is determined suitable for varying the effect of the gravitational action on said at least one part of the body; wherein the apparatus further comprises means for inducing onto the same at least one part of the body supported by said footboard an action suitable for determining a hyperthermy in at least a portion of said at least one part of the body; control and actuation means that actuate and control at least the concurrent operation of said means for stressing the footboard and said hyperthermy inducing means suitable for warming