Patents Assigned to BIOSCEPTRE (AUST) PTY LTD
  • NOVEL DYSFUNCTIONAL P2X7 BINDERS
    Publication number: 20240376193
    Abstract: The present invention relates to novel antigen binding proteins for binding to dysfunctional P2X7 receptor.
    Type: Application
    Filed: September 1, 2022
    Publication date: November 14, 2024
    Applicant: BIOSCEPTRE (AUST) PTY LTD
    Inventors: Patrick Schlegel, Julian Alexander Barden, Daniel Ulrich Christ, Peter Robert Schofield
  • Anti P2X7 receptor antibodies and fragments thereof
    Patent number: 12129295
    Abstract: The invention relates to an antigen binding site for binding to a P2X7 receptor, the antigen binding site being defined by general formula 1: FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4.
    Type: Grant
    Filed: March 10, 2021
    Date of Patent: October 29, 2024
    Assignee: BIOSCEPTRE (AUST) PTY LTD
    Inventors: Julian Alexander Barden, Neil Brewis, Philip Jones, Steven Grant
  • Chimeric antigen receptors and uses thereof
    Patent number: 12121539
    Abstract: The present invention relates to chimeric antigen receptors (CARs) directed to cells expressing a dysfunctional or non-functional P2X purinoceptor 7 receptor. Further provided are methods of targeting neoplastic cells and tumours expressing a dysfunctional or non-functional P2X purinoceptor 7 receptor and methods of treating and preventing cancer is a subject.
    Type: Grant
    Filed: September 10, 2016
    Date of Patent: October 22, 2024
    Assignee: BIOSCEPTRE (AUST) PTY LTD
    Inventors: Justin Taylor Coombs, Simon Charles Barry, Timothy John Sadlon
  • Cytotoxic particles for targeting P2X7 receptor
    Patent number: 12097265
    Abstract: The invention relates to cytotoxic particles for cancer therapy including a core and a plurality of variable domains arranged on the core for binding to P2X7 receptors on a cancer cell.
    Type: Grant
    Filed: January 13, 2022
    Date of Patent: September 24, 2024
    Assignee: BIOSCEPTRE (AUST) PTY LTD
    Inventors: Xiaojuan Gong, Minoo J Moghaddam, Julian Alexander Barden
  • ANTI P2X7 RECEPTOR ANTIBODIES AND FRAGMENTS THEREOF
    Publication number: 20220315652
    Abstract: The invention relates to an antigen binding site for binding to a P2X7 receptor, the antigen binding site being defined by general formula 1: FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4
    Type: Application
    Filed: March 10, 2021
    Publication date: October 6, 2022
    Applicant: BIOSCEPTRE (AUST) PTY LTD
    Inventors: Julian Alexander Barden, Neil Brewis, Philip Jones, Steven Grant
  • Cytotoxic particles for targeting P2X7 receptor
    Patent number: 11260131
    Abstract: The invention relates to cytotoxic particles for cancer therapy including a core and a plurality of variable domains arranged on the core for binding to P2X7 preceptorson a cancer cell.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: March 1, 2022
    Assignee: BIOSCEPTRE (AUST) PTY LTD
    Inventors: Xiaojuan Gong, Minoo J Moghaddam, Julian Alexander Barden
  • Anti P2Xreceptor antibodies and fragments thereof
    Patent number: 10988532
    Abstract: The invention relates to an antigen binding site for binding to a P2X7 receptor, the antigen binding site being defined by general formula 1: FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: April 27, 2021
    Assignee: BIOSCEPTRE (AUST) PTY LTD
    Inventors: Julian Alexander Barden, Neil Brewis, Philip Jones, Steven Grant
  • Methods of treating cancer with a P2X7 peptide
    Patent number: 10597451
    Abstract: The invention relates to purinergic (P2X) receptors, more specifically to P2X7 receptors, the generation of antibodies and the use of antibodies and immunogens that are capable of selectively binding to a non ATP-binding P2X7 receptor but not to an ATP-binding P2X7 receptor, for the detection and treatment of disease conditions, especially cancer.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: March 24, 2020
    Assignee: BIOSCEPTRE (AUST) PTY LTD
    Inventors: Julian Alexander Barden, Angus Gidley-Baird
  • ANTIBODIES TO NON-FUNCTIONAL P2X7 RECEPTOR
    Publication number: 20200071419
    Abstract: The present invention provides antibodies that specifically bind to P2X7 receptors and distinguish between function and non-functional P2X7 receptors, pharmaceutical compositions and kits containing the antibodies, and methods of using the antibodies for the detection, diagnosis and treatment of disease conditions.
    Type: Application
    Filed: September 11, 2019
    Publication date: March 5, 2020
    Applicant: BIOSCEPTRE (AUST) PTY LTD
    Inventors: Julian Alexander Barden, Angus Gidley-Baird
  • Combination therapy utilizing P2X7 peptides
    Patent number: 10543262
    Abstract: The invention relates to producing humoral response to P2X7 receptors in individuals having cancer, and to minimising the progression of cancer in said individuals.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: January 28, 2020
    Assignee: BIOSCEPTRE (AUST) PTY LTD
    Inventors: Julian Alexander Barden, Angus Gidley-Baird
  • Polypeptide immunogen for generating an antibody to non-functional P2X7 receptor
    Patent number: 10450380
    Abstract: The present invention provides antibodies that specifically bind to P2X7 receptors and distinguish between function and non-functional P2X7 receptors, pharmaceutical compositions and kits containing the antibodies, and methods of using the antibodies for the detection, diagnosis and treatment of disease conditions.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: October 22, 2019
    Assignee: BIOSCEPTRE (AUST) PTY LTD
    Inventors: Julian Alexander Barden, Angus Gidley-Baird
  • Combination Therapy Utilizing P2X7 Peptides
    Publication number: 20190224290
    Abstract: The invention relates to producing humoral response to P2X7 receptors in individuals having cancer, and to minimising the progression of cancer in said individuals.
    Type: Application
    Filed: February 5, 2019
    Publication date: July 25, 2019
    Applicant: BIOSCEPTRE (AUST) PTY LTD
    Inventors: Julian Alexander Barden, Angus Gidley-Baird
  • Combination therapy utilizing P2X7 peptides
    Patent number: 10245308
    Abstract: The invention relates to producing humoral response to P2X7 receptors in individuals having cancer, and to minimizing the progression of cancer in said individuals.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: April 2, 2019
    Assignee: BIOSCEPTRE (AUST) PTY LTD
    Inventors: Julian Alexander Barden, Angus Gidley-Baird
  • Anti-P2Xpeptides and epitopes
    Patent number: 10238716
    Abstract: The invention relates to the identification of a novel epitope on non-function P2X7 receptors which are implicated in cancer. The epitope includes a region from two adjacent monomers within the three subunit receptor. Antibodies which bind to the epitope and peptides for generating the antibodies are described. The antibodies and peptides are useful in the diagnosis and treatment of cancer.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: March 26, 2019
    Assignee: BIOSCEPTRE (AUST) PTY LTD
    Inventors: Julian Alexander Barden, Angus Gidley-Baird
  • Anti P2X7 receptor antibodies and fragments thereof
    Patent number: 10053508
    Abstract: The invention relates to an antigen binding site for binding to a P2X7 receptor, the antigen binding site being defined by general formula 1: FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: August 21, 2018
    Assignee: BIOSCEPTRE (AUST) PTY LTD
    Inventors: Julian Alexander Barden, Neil Brewis, Philip Jones, Steven Grant
  • Methods of treating cancer with antibodies that bind P2X7 receptors
    Patent number: 9944701
    Abstract: The invention relates to purinergic (P2X) receptors, to generation of antibodies and to use of antibodies and immunogens for detection and treatment of a disease or condition, especially cancer.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: April 17, 2018
    Assignee: BIOSCEPTRE (AUST) PTY LTD
    Inventors: Julian Alexander Barden, Angus Gidley-Baird
  • Anti P2Xreceptor antibodies and fragments thereof
    Patent number: 9688771
    Abstract: The invention relates to an antigen binding site for binding to a P2X7 receptor, the antigen binding site being defined by general formula 1: FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: June 27, 2017
    Assignee: BIOSCEPTRE (AUST) PTY LTD
    Inventors: Julian Alexander Barden, Neil Brewis, Philip Jones, Steven Grant
  • Antibodies to non-functional P2X7 receptor
    Patent number: 9663584
    Abstract: The present invention provides antibodies that specifically bind to P2X7 receptors and distinguish between function and non-functional P2X7 receptors, pharmaceutical compositions and kits containing the antibodies, and methods of using the antibodies for the detection, diagnosis and treatment of disease conditions.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: May 30, 2017
    Assignee: BIOSCEPTRE (AUST) PTY LTD
    Inventors: Julian Alexander Barden, Angus Gidley-Baird
  • Combination therapy
    Patent number: 9566318
    Abstract: The invention relates to producing humoral response to P2X7 receptors in individuals having cancer, and to minimizing the progression of cancer in said individuals.
    Type: Grant
    Filed: July 2, 2012
    Date of Patent: February 14, 2017
    Assignee: Biosceptre (Aust) Pty Ltd
    Inventors: Julian Alexander Barden, Angus Gidley-Baird
  • Companion animal treatments
    Patent number: 9562094
    Abstract: The invention relates to minimizing the progression of cancer in a companion animal using P2X7 immunotherapy.
    Type: Grant
    Filed: September 9, 2011
    Date of Patent: February 7, 2017
    Assignee: BIOSCEPTRE (AUST) PTY LTD
    Inventors: Julian Alexander Barden, Angus Gidley-Baird