Patents Assigned to Bioscience, Inc.
  • USP30 inhibitors and uses thereof
    Patent number: 11845724
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of USP30, and the treatment of USP30-mediated disorders.
    Type: Grant
    Filed: September 11, 2020
    Date of Patent: December 19, 2023
    Assignee: Vincere Biosciences, Inc.
    Inventors: Donna L. Romero, Michael Garrett Johnson, Andrew David Lee, Bahareh Behrouz, Edward Lawrence Fritzen, Jr.
  • Systems and methods for counting cells
    Patent number: 11846579
    Abstract: According to at least one aspect, a system configured to count cells in a vessel is provided. The system comprises an imaging system configured to image cells in the vessel and a controller coupled to the imaging system. The controller is configured to control the imaging system to capture a focused image of the cells and estimate a number of cells in the focused image. The controller is configured to control the imaging system to capture a focused image of the cells at least in part by controlling the imaging system to capture a plurality of images of the cells in a plurality of focal planes, determining an area of at least one cell in each of the plurality of images, and selecting one image from the plurality of images as the focused image using the area of the at least one cell in the plurality of images.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: December 19, 2023
    Assignee: Thrive Bioscience, Inc.
    Inventors: Kam Lin Wong, Melanie Scully
  • Methods and reagents for characterizing genomic editing, clonal expansion, and associated applications
    Patent number: 11845985
    Abstract: Methods for characterizing genome editing, clonal expansion and associated reagents for use in such methods are disclosed herein. Some embodiments of the technology are directed to characterizing a population of cells following an engineered genomic editing event, that includes in some embodiments characterizing genomic alterations occurring at both intended and unintended genomic loci within the genome of the populations of cells. Other embodiments are directed to utilizing Duplex Sequencing for assessing a clonal selection in mixed cell populations and/or cell populations following a genomic editing event. Further examples of the present technology are directed to methods for detecting and assessing clonal expansion of cells following a genomic editing event.
    Type: Grant
    Filed: May 10, 2022
    Date of Patent: December 19, 2023
    Assignee: TwinStrand Biosciences, Inc.
    Inventors: Jesse J. Salk, Charles Clinton Valentine, III
  • POLYMORPHS OF SUBSTITUTED ISOQUINOLINE-BASED RHO KINASE INHIBITORS
    Publication number: 20230399311
    Abstract: The present disclosure relates to crystalline polymorphs of (R)-1-(1-(isoquinolin-5-ylsulfonyl)piperidin-4-yl)ethan-1-amine, salts thereof, pharmaceutical compositions thereof, pharmaceutical compositions comprising crystalline polymorphs of (R)-1-(1-(isoquinolin-5-ylsulfonyl)piperidin-4-yl)ethan-1-amine, salts thereof and methods of treatment of neurological conditions including cavernous angioma, cerebral aneurysm, stroke, subarachnoid hemorrhage, vasospasm after subarachnoid hemorrhage, traumatic brain injury, spinal cord injury, spinal cord injury stroke, seizures, hereditary hemorrhagic telangiectasis, cerebral arteriovascular malformations, sporadic cavernous angioma lesion, cerebral cavernous malformation, or combinations thereof, using the same.
    Type: Application
    Filed: June 9, 2023
    Publication date: December 14, 2023
    Applicants: BioAxone BioSciences, Inc., Neurelis, Inc.
    Inventors: Kenneth M. ROSEN, Matthew D. ABBINANTI, Lisa MCKERRACHER, Stuart MADDEN
  • Natural product and genetic data analysis and discovery system, method and computational platform therefor
    Patent number: 11842798
    Abstract: A method for linking a natural product and gene cluster is disclosed. In some embodiments, monomers of natural products are predicted from a gene sequence. In other embodiments, monomers of natural products are predicted from a chemical structure of a natural product. In another embodiment, monomers predicted from gene sequences are aligned with monomers predicted from chemical structures.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: December 12, 2023
    Assignee: Adapsyn Bioscience Inc.
    Inventors: Nishanth Merwin, Chris DeJong, Chad Johnston, Gregory Chen, Haoxin Li, Michael Skinnider, McLean Edwards, Nathan Magarvey, Phil Rees
  • Methods for sample preparation
    Patent number: 11834657
    Abstract: The disclosure provides for single amplification and double amplification methods for preparing nucleic acid samples for sequencing.
    Type: Grant
    Filed: June 12, 2018
    Date of Patent: December 5, 2023
    Assignees: University of Southern California, SeqOnce Biosciences Inc.
    Inventor: Joseph Dunham
  • Bioerodible implant for long-term drug delivery and associated methods of manufacture and use
    Patent number: 11833244
    Abstract: A drug delivery system is provided in the form of a controlled release, bioerodible pellet for subdermal implantation. The pellet is bioerodible, and provides for the sustained release of a pharmacologically active agent over an extended time period. As such, the drug delivery system finds significant utility in chronic drug administration. Bioerosion products are water soluble, bioresorbed, or both, obviating the need for surgical removal of the implant. Methods for manufacturing and using the drug delivery system are also provided.
    Type: Grant
    Filed: November 19, 2021
    Date of Patent: December 5, 2023
    Assignee: Gesea Biosciences Inc.
    Inventors: John H. Baillie, Ruth Baillie, George Blouin, Newsha Farahani, Christopher Marx
  • Multispectral sample imaging
    Patent number: 11835463
    Abstract: The disclosure features methods that include exposing a biological sample to illumination light and measuring light emission from the sample to obtain N sample images, where each sample image corresponds to a different combination of a wavelength band of the illumination light and one or more wavelength bands of the light emission, where the one or more wavelength bands of the light emission define a wavelength range, and where N>1, and exposing the sample to illumination light in a background excitation band and measuring light emission from the sample in a background spectral band to obtain a background image of the sample, where the background spectral band corresponds to a wavelength within the wavelength range.
    Type: Grant
    Filed: April 14, 2022
    Date of Patent: December 5, 2023
    Assignee: Akoya Biosciences, Inc.
    Inventors: Peter J. Miller, Kent S. Johnson, Carla Coltharp
  • ANTI-ROR1 ANTIBODY AND ROR1-TARGETING ENGINEERED CELLS
    Publication number: 20230383009
    Abstract: The present invention is directed to a monoclonal mouse or humanized ROR1 antibody, or a single-chain variable fragment (scFv). The present invention is also directed to a mouse or humanized ROR1 chimeric antigen receptor (CAR) comprising from N-terminus to C-terminus: (i) a single-chain variable fragment (scFv) of the present invention, (ii) a transmembrane domain, (iii) at least one co-stimulatory domains, and (iv) an activating domain.
    Type: Application
    Filed: May 22, 2023
    Publication date: November 30, 2023
    Applicant: Caribou Biosciences, Inc.
    Inventors: Vita Golubovskaya, Lijun Wu
  • Compositions and methods related to anti-CD19 antibody drug conjugates
    Patent number: 11827703
    Abstract: The present disclosure relates to antibody-drug conjugates (ADCs) wherein one or more active agents are conjugated to an anti-CD19 antibody through a linker. The linker may comprise a unit that covalently links active agents to the antibody. The disclosure further relates to monoclonal antibodies and antigen binding fragments, variants, multimeric versions, or bispecifics thereof that specifically bind CD19, as well as methods of making and using these anti-CD19 antibodies and antigen-binding fragments thereof in a variety of therapeutic, diagnostic and prophylactic indications.
    Type: Grant
    Filed: May 9, 2019
    Date of Patent: November 28, 2023
    Assignees: LegoChem Biosciences, Inc., NovImmune, SA
    Inventors: Ho Young Song, Yun Hee Park, Sung Min Kim, Hyoung Rae Kim, Ji Hye Oh, Hyun Min Ryu, Jeiwook Chae, Yeong Soo Oh, Yong Zu Kim, Maureen Deehan, Nicolas Fischer
  • Methods and systems for single cell gene profiling
    Patent number: 11827936
    Abstract: This disclosure provides methods and systems for single-cell analysis, including single-cell transcriptome analysis, of target cells without microfluidic devices. The disclosed methods involve the use of template particles to template the formation of monodisperse droplets to generally capture a single target cell from a population of cells in an encapsulation, derive a plurality of distinct mRNA molecules from the single target cell, and quantify the distinct mRNA molecules to generate an expression profile.
    Type: Grant
    Filed: January 12, 2021
    Date of Patent: November 28, 2023
    Assignee: Fluent Biosciences Inc.
    Inventors: Kristina Fontanez, Robert Meltzer, Yi Xue, Christopher D'amato, Sepehr Kiani
  • Bacteriophage-based vaccines and engineered bacteriophage
    Patent number: 11826421
    Abstract: Engineered bacteriophage and methods of forming the bacteriophage are described. Multivalent bacteriophage are described that can include multiple different exogenous polypeptides at a surface of the capsid head. Vaccines and methods of forming and using vaccines are described. A vaccine can include an engineered bacteriophage that exhibits an immunogenic exogenous polypeptide at a surface of the bacteriophage. Multivalent bacteriophage and immunogenic bacteriophage are free of nucleic acids encoding the exogenous polypeptide(s).
    Type: Grant
    Filed: March 18, 2021
    Date of Patent: November 28, 2023
    Assignee: Athanor Biosciences, Inc.
    Inventors: Hossein A Ghanbari, Michael S. Lebowitz
  • SYNTHETIC NANOCARRIERS COMPRISING AN IMMUNOSUPPRESSANT IN COMBINATION WITH HIGH AFFINITY IL-2 RECEPTOR AGONISTS AND ANTI-IGM AGENTS
    Publication number: 20230372535
    Abstract: Disclosed are methods and related compositions for administering a high affinity IL-2 receptor agonist, an anti-IgM agent and immunosuppressant (e.g., synthetic nanocarriers comprising immunosuppressant) in combination. The methods and compositions provided can be used for modulating an immune response to an antigen, such as by enhancing regulatory T cells, such as antigen-specific regulatory T cells.
    Type: Application
    Filed: March 24, 2023
    Publication date: November 23, 2023
    Applicant: Selecta Biosciences, Inc.
    Inventor: Takashi Kei Kishimoto
  • Methods and systems for determining spatial patterns of biological targets in a sample
    Patent number: 11821024
    Abstract: The present disclosure provides methods and assay systems for use in spatially encoded biological assays, including assays to determine a spatial pattern of abundance, expression, and/or activity of one or more biological targets across multiple sites in a sample. In particular, the biological targets comprise proteins, and the methods and assay systems do not depend on imaging techniques for the spatial information of the targets. The present disclosure provides methods and assay systems capable of high levels of multiplexing where reagents are provided to a biological sample in order to address tag the sites to which reagents are delivered; instrumentation capable of controlled delivery of reagents; and a decoding scheme providing a readout that is digital in nature.
    Type: Grant
    Filed: March 31, 2023
    Date of Patent: November 21, 2023
    Assignee: Prognosys Biosciences, Inc.
    Inventors: Mark S. Chee, David A. Routenberg
  • LIPID NANOPARTICLE COMPOSITIONS
    Publication number: 20230365995
    Abstract: The present invention provides lipid nanoparticle compositions, and methods of using the same, that are useful for introducing nucleic acids into eukaryotic cells, such as human immune cells. Generally, the lipid nanoparticles described herein comprise an apolipoprotein that is bound to one component of the lipid nanoparticles. The apolipoprotein can be bound to the lipid nanoparticle components by various types of bonds, including covalent bonds. The invention further provides methods for transfecting eukaryotic cells with such lipid nanoparticles, populations of eukaryotic cells, pharmaceutical compositions, and methods of treatment and use.
    Type: Application
    Filed: October 6, 2021
    Publication date: November 16, 2023
    Applicant: Precision BioSciences, Inc.
    Inventor: Tyler Goodwin
  • METHODS AND COMPOSITIONS FOR ATTENUATING ANTI-VIRAL TRANSFER VECTOR IMMUNE RESPONSES
    Publication number: 20230364124
    Abstract: Provided herein are methods and related compositions for administering viral transfer vectors and antigen-presenting cell targeted immunosuppressants.
    Type: Application
    Filed: March 17, 2023
    Publication date: November 16, 2023
    Applicant: Selecta Biosciences, Inc.
    Inventor: Takashi Kei Kishimoto
  • Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
    Patent number: 11814361
    Abstract: BA-1049 (R) and its active metabolite are disclosed. Also disclosed are pharmaceutical formulations containing BA-1049 (R) or its active metabolite.
    Type: Grant
    Filed: July 21, 2021
    Date of Patent: November 14, 2023
    Assignee: BioAxone BioSciences, Inc.
    Inventors: Kenneth M. Rosen, Matthew D. Abbinanti, Joerg Ruschel, Lisa McKerracher, Lisa Bond Moritz
  • Hepatitis b core protein modulators
    Patent number: 11814376
    Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
    Type: Grant
    Filed: January 4, 2021
    Date of Patent: November 14, 2023
    Assignees: Assembly Biosciences, Inc., Indiana University Research and Technology Corporation
    Inventors: William W. Turner, Jr., Lee D. Arnold, Hans Maag, Leping Li, Mark G. Bures, Simon Nicolas Haydar, Samson Francis
  • Methods and compositions for preserving bacteria
    Patent number: 11814615
    Abstract: The disclosure provides methods and compositions for the preservation of bacteria.
    Type: Grant
    Filed: August 29, 2022
    Date of Patent: November 14, 2023
    Assignee: Vedanta Biosciences, Inc.
    Inventors: Daniel E. Couto, Shilpa Reddy, Jil Ulrich, Scott Michonski
  • Effector proteins and methods of use
    Patent number: 11814620
    Abstract: Provided herein are compositions, systems, and methods comprising effector proteins and uses thereof. These effector proteins are shown to be active with guide RNAs and may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure leverage the activities of these effector proteins for the modification, detection, and engineering of nucleic acids.
    Type: Grant
    Filed: May 17, 2022
    Date of Patent: November 14, 2023
    Assignee: Mammoth Biosciences, Inc.
    Inventors: Benjamin Julius Rauch, Aaron DeLoughery, William Douglass Wright, David Paez-Espino, Clarissa Oriel Rhines, Lucas Benjamin Harrington, Wiputra Jaya Hartono