Patents Assigned to Bioscience, Inc.
  • Pyrrolobenzodiazepine dimer prodrug and ligand-linker conjugate compound of the same
    Patent number: 11654197
    Abstract: The present disclosure relates to pyrrolobenzodiazepine dimer prodrugs and ligand-linker conjugates thereof. The present disclosure also relates to compositions and uses of said prodrugs and conjugates.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: May 23, 2023
    Assignee: LegoChem Biosciences, Inc.
    Inventors: Ho Young Song, Sung Min Kim, Hyoungrae Kim, Kyung Eun Park, Chul-Woong Chung, Yun Hee Park, Hyo Jung Choi, Su In Lee, Juyuel Baek, Hyeun Joung Lee, Ju Young Lee, Ji Hye Oh, Jeiwook Chae, Yeong Soo Oh, Yong Zu Kim
  • HYDROGEL PARTICLES WITH TUNABLE OPTICAL PROPERTIES AND METHODS FOR USING THE SAME
    Publication number: 20230152202
    Abstract: Hydrogel particles and their use in cytometric applications are described. The hydrogel particles described herein are selectively tunable to have at least one optical property substantially similar to at least one optical property of a target cell. In this regard, the hydrogel particles provided herein, in one aspect, are used as a calibration reagent for the detection of a target cell in a sample.
    Type: Application
    Filed: November 18, 2022
    Publication date: May 18, 2023
    Applicant: Slingshot Biosciences, Inc.
    Inventors: Jeffrey KIM, Oliver LIU, Jeremy AGRESTI, Anh Tuan NGUYEN
  • Substituted pyrido[2,3-d]pyrimidines as inhibitors of Ras pathway signaling
    Patent number: 11648254
    Abstract: The present disclosure provides compounds represented by Formula (I-1): and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.
    Type: Grant
    Filed: March 2, 2022
    Date of Patent: May 16, 2023
    Assignee: Kumquat Biosciences Inc.
    Inventors: Baogen Wu, Xiangzhu Wang, Xiaoming Li, Zhiyong Chen, Pingda Ren, Yi Liu
  • PD-L1 and OX40 binding proteins for cancer Regulation
    Patent number: 11643470
    Abstract: Provided are monospecific and bispecific proteins that bind specifically to OX40 and/or PD-L1. Exemplary proteins release the inhibition through PD-L1 and stimulate T cell through OX40. Exemplary polyvalent proteins comprise at least one OX40 binding site and at least one PD-L1 binding site. In certain embodiments, the binding sites may be linked through an immunoglobulin constant region. Anti-OX40 and anti-PD-L1 antibodies are also provided.
    Type: Grant
    Filed: May 11, 2020
    Date of Patent: May 9, 2023
    Assignee: AP Biosciences, Inc.
    Inventors: Jhong-Jhe You, Ching-Hsuan Hsu, Po-Lin Huang, Hung-Tsai Kan, Ting-Yi Chang, Hsin-Ta Hsieh, Jeng-Horng Her
  • OSMOTIC MEDIATED RELEASE SYNTHETIC NANOCARRIERS
    Publication number: 20230139671
    Abstract: This invention relates, at least in part, to osmotic mediated release barrier-free synthetic nanocarriers and methods of production and use.
    Type: Application
    Filed: July 28, 2022
    Publication date: May 4, 2023
    Applicant: Selecta Biosciences, Inc.
    Inventors: David H. Altreuter, Aaron P. Griset
  • Treatment instrument and high-voltage connectors for robotic surgical system
    Patent number: 11638815
    Abstract: Described herein are methods and systems for using the treatment tip apparatuses and high-voltage connectors with robotic surgical systems. For example, retractable treatment tip apparatuses (e.g., devices, systems, etc.) including one, or more preferably a plurality, of electrodes that are protected by a housing (which may be retractable) until pressed against the tissue for deployment of the electrodes and delivery of a therapeutic treatment, are disclosed. In particular, these apparatuses may include a plurality of treatment needle electrodes and may be configured for the delivery of nanosecond pulsed electric fields. Also described herein are high-voltage connectors configured to provide high-voltage energy, such as nsPEF pulses, from a generator to the retractable treatment tip apparatuses.
    Type: Grant
    Filed: October 22, 2020
    Date of Patent: May 2, 2023
    Assignee: Pulse Biosciences, Inc.
    Inventors: David J. Danitz, Cameron D Hinman, Kenneth R. Krieg, Kevin L. Moss, Christopher J. Foster, Darrin R. Uecker
  • Methods and compositions for altering secondary metabolites in plants
    Patent number: 11638427
    Abstract: The disclosure relates to methods and compositions for altering the production of one or more secondary plant metabolites comprising applying an effective amount of at least one elicitor, wherein the elicitor is a jasmonate or a salicylate, and combinations thereof. The disclosure further teaches compositions comprising effective amounts of the elicitors disclosed here. The disclosure further relates to methods and compositions for controlling plant pathogens, such as fungal pathogens.
    Type: Grant
    Filed: October 8, 2021
    Date of Patent: May 2, 2023
    Assignee: Impello Biosciences, Inc.
    Inventors: Michael C. Key, Lindsey R. Adler, Michael J. Dilegge
  • Binding molecules with modified J-chain
    Patent number: 11639389
    Abstract: The present invention provides binding molecules that include an IgM, IgA, IgG/IgM or IgG/IgA antibody with a modified J-chain that includes a binding moiety that antagonizes a T-cell inhibitory signaling pathway, and their uses.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: May 2, 2023
    Assignee: IGM Biosciences, Inc.
    Inventors: Bruce A. Keyt, Leonard G. Presta, Ramesh Baliga
  • EXTRACELLULAR VESICLE-NLRP3 ANTAGONIST
    Publication number: 20230132093
    Abstract: The present disclosure relates to extracellular vesicles, e.g., exosomes, comprising an NLRP3 antagonist. In some aspects, the NLRP3 antagonist comprises an antisense oligonucleotide (ASO). Also provided herein are methods for producing the exosomes and methods for using the exosomes to treat and/or prevent diseases or disorders.
    Type: Application
    Filed: August 14, 2020
    Publication date: April 27, 2023
    Applicant: Codiak BioSciences, Inc.
    Inventors: Joanne LIM, Katherine KIRWIN, Wendy BROOM, Sriram SATHYANARAYANAN, Ajay VERMA
  • Spatially encoded biological assays
    Patent number: 11634756
    Abstract: The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.
    Type: Grant
    Filed: October 24, 2022
    Date of Patent: April 25, 2023
    Assignee: Prognosys Biosciences, Inc.
    Inventor: Mark S. Chee
  • Blocking antibodies against CD47 and methods of use thereof
    Patent number: 11634490
    Abstract: Provided are anti-CD47 antibodies or fragments thereof that can bind to the extra cellular domain of the CD47 protein. The antibodies or fragments thereof can effectively block the interaction between human CD47 and its ligand SIRP alpha and enhance the phagocytosis activity of macrophages to engulf cancer cells. Some of these antibodies or fragments do not induce in vitro hemagglutination and therefore can be suitably used as therapeutic agents with reduced off-target effects.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: April 25, 2023
    Assignee: Accurus Biosciences, Inc.
    Inventors: Haishan Lin, Yi Zhang
  • Methods and compositions for attenuating anti-viral transfer vector immune responses
    Patent number: 11633422
    Abstract: Provided herein are methods and related compositions for administering viral transfer vectors and antigen-presenting cell targeted immunosuppressants.
    Type: Grant
    Filed: September 7, 2015
    Date of Patent: April 25, 2023
    Assignee: Selecta Biosciences, Inc.
    Inventor: Takashi Kei Kishimoto
  • Networked incubator operation
    Patent number: 11634682
    Abstract: Aspects of the present invention relate to a networked cell culture incubator and to methods for operating such an incubator. In one aspect, the cell culture incubator includes a network interface for communicating with a source of parameter data utilized successfully by other incubators. The incubator receives appropriate parameter data and conducts the incubation process as prescribed by the parameter data so as to provide an improved environment for cell culture growth. The incubator may share its own parameter data with the data source for use by other incubators. The incubator and data source may share other forms of data as well.
    Type: Grant
    Filed: August 12, 2021
    Date of Patent: April 25, 2023
    Assignee: Thrive Bioscience, Inc.
    Inventor: Howard Cannon
  • METHODS AND COMPOSITIONS RELATED TO COMBINED TREATMENT WITH ANTI-INFLAMMATORIES AND SYNTHETIC NANOCARRIERS COMPRISING AN IMMUNOSUPPRESSANT
    Publication number: 20230119226
    Abstract: Provided herein are methods and compositions, such as kits, related to compositions comprising synthetic nanocarriers comprising an immunosuppressant and compositions comprising an uricase and a composition comprising an anti-inflammatory therapeutic. Also provided herein are methods and compositions for the treatment of subjects in need of administration or treatment with the uricase.
    Type: Application
    Filed: July 21, 2022
    Publication date: April 20, 2023
    Applicant: Selecta Biosciences, Inc.
    Inventor: Lloyd Johnston
  • EXTRACELLULAR VESICLES FOR TREATING NEUROLOGICAL DISORDERS
    Publication number: 20230114434
    Abstract: The present disclosure relates to extracellular vesicles (EVs) that are capable of targeting a cell in the CNS of a subject. Also provided herein are methods for producing the EVs and methods for using the EVs to treat and/or prevent diseases or disorders of the CNS (e.g., neurological disorders).
    Type: Application
    Filed: March 15, 2021
    Publication date: April 13, 2023
    Applicant: Codiak BioSciences, Inc.
    Inventors: Ajay VERMA, Tim SOOS, Nikki ROSS, Christine MCCOY, Jonathan FINN, Sriram SATHYANARAYANAN, Shailendra PATEL, Ke XU, Russell E. MCCONNELL, Kevin P. DOOLEY
  • Heterocyclic modulators of lipid synthesis
    Patent number: 11622968
    Abstract: Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).
    Type: Grant
    Filed: April 2, 2020
    Date of Patent: April 11, 2023
    Assignee: Sagimet Biosciences Inc.
    Inventors: Douglas Buckley, Gregory Duke, Allan S. Wagman, Marc Evanchik, Robert S. McDowell
  • METHODS OF PRODUCING EXTRACELLULAR VESICLES
    Publication number: 20230103726
    Abstract: Provided herein are methods of preparing EVs, e.g., exosomes, associated with or encapsulated various cyclic dinucleotides, including STING agonists. Also provided herein are methods of loading EVs, e.g., exosomes, with various cyclic dinucleotides, including STING agonists.
    Type: Application
    Filed: September 25, 2020
    Publication date: April 6, 2023
    Applicant: Codiak BioSciences, Inc.
    Inventors: Raymond BOURDEAU, Su Chul JANG, Rane HARRISON, Conlin O'NEIL, Aaron NOYES
  • PRE-SCAN FOCUS AND SCAN FOCUS METHODS
    Publication number: 20230105170
    Abstract: A method for pre-scanning a transparent cell culture plate with a plurality of wells to improve focus using a plurality of z-axis images and a method for focusing an optical system on a transparent cell culture plate by performing a Fourier transform on image data at different focus distance steps to reveal a pattern and using the pattern at each step to determine the focus distance.
    Type: Application
    Filed: February 26, 2021
    Publication date: April 6, 2023
    Applicant: Thrive Bioscience, Inc.
    Inventors: Jeff GOLDMAN, Alan BLANCHARD
  • METHODS AND COMPOSITIONS RELATED TO COMBINED TREATMENT WITH ANTI-INFLAMMATORIES AND SYNTHETIC NANOCARRIERS COMPRISING AN IMMUNOSUPPRESSANT
    Publication number: 20230107561
    Abstract: Provided herein are methods and compositions, such as kits, related to compositions comprising synthetic nanocarriers comprising an immunosuppressant and compositions comprising an uricase and a composition comprising an anti-inflammatory therapeutic. Also provided herein are methods and compositions for the treatment of subjects in need of administration or treatment with the uricase.
    Type: Application
    Filed: August 30, 2022
    Publication date: April 6, 2023
    Applicant: Selecta Biosciences, Inc.
    Inventor: Lloyd Johnston
  • plant named ‘PCT11204V’
    Patent number: PP35172
    Abstract: A new and distinct variety of Cannabis sativa designated ‘PCT11204V’ as herein described and illustrated, characterized by elevated levels of THCV and other varin cannabinoids.
    Type: Grant
    Filed: March 11, 2022
    Date of Patent: May 16, 2023
    Assignee: Phylos Bioscience, Inc.
    Inventors: Jared Reynbery, Alisha Holloway, Erica Bakker, John McFerson