Patents Assigned to Bioscience, Inc.
  • Compositions for Inhibiting PP2A Demethylation
    Publication number: 20190336561
    Abstract: Compositions containing natural and botanical extracts for use in inhibiting one, two, or three of (a)-(c): (a) demethylation of PP2A by PME-1 methylesterase; (b) formation of free radicals and reactive oxygen species; and/or (c) inflammation. These compositions include an extract of one or more botanicals selected from the group consisting of: juniper berry fruit, schisandra fruit, strawberry fruit, avocado seeds, black raspberry seeds, blueberry seeds, celery seeds, cranberry seeds, fennel seeds, grape seeds, guarana seeds, red raspberry seeds, maca root, goldenseal root, turmeric root, magnolia bark, pygeum bark, red raspberry leaf, almond, cocoa powder, Echinacea angustifolia, prickly pear cactus and walnut.
    Type: Application
    Filed: July 17, 2019
    Publication date: November 7, 2019
    Applicant: Signum Biosciences, Inc.
    Inventors: Kristen Huber, Michael Voronkov, Jose Fernandez, Karl Rouzard, Eduardo Perez, Maxwell Stock, Jeffry Stock
  • OPTIMIZED ENGINEERED MEGANUCLEASES HAVING SPECIFICITY FOR A RECOGNITION SEQUENCE IN THE HEPATITIS B VIRUS GENOME
    Publication number: 20190338263
    Abstract: The present invention encompasses engineered nucleases which recognize and cleave a recognition sequence within a Hepatitis B virus (HBV) genome. The engineered meganucleases can exhibit at least one optimized characteristic, such as enhanced specificity and/or efficiency of indel formation, when compared to the first-generation meganuclease HBV 11-12x.26. Further, the invention encompasses pharmaceutical compositions comprising engineered meganuclease proteins, nucleic acids encoding engineered meganucleases, and the use of such compositions for treating HBV infections or hepatocellular carcinoma.
    Type: Application
    Filed: April 11, 2019
    Publication date: November 7, 2019
    Applicant: Precision BioSciences, Inc.
    Inventors: James Jefferson Smith, Janel Lape, Victor Bartsevich, Hui Li
  • TRANSGENIC LAND PLANTS COMPRISING A PUTATIVE TRANSPORTER PROTEIN OF AN EDIBLE EUKARYOTIC ALGAE
    Publication number: 20190338302
    Abstract: A transgenic land plant is provided. The transgenic land plant comprises a putative bicarbonate transporter protein of an edible eukaryotic algae. The putative bicarbonate transporter protein of the edible eukaryotic algae is heterologous with respect to the transgenic land plant. The putative bicarbonate transporter protein is an ortholog of CCP1 of Chlamydomonas reinhardtii of SEQ ID NO: 1. The putative bicarbonate transporter protein is localized to mitochondria of the transgenic land plant based on a mitochondrial targeting signal intrinsic to the putative bicarbonate transporter protein.
    Type: Application
    Filed: February 3, 2017
    Publication date: November 7, 2019
    Applicant: Yield10 Bioscience, Inc.
    Inventors: Oliver P. Peoples, Kristi D. Snell, Meghna Malik
  • Etanercept Formulations Stabilized with Sodium Chloride
    Publication number: 20190336601
    Abstract: The invention provides stabilized aqueous pharmaceutical etanercept compositions suitable for long-term storage of etanercept, methods of manufacture of these compositions, methods of administration, and kits containing same.
    Type: Application
    Filed: June 26, 2019
    Publication date: November 7, 2019
    Applicant: Coherus Biosciences, Inc.
    Inventors: Mark MANNING, Brian MURPHY
  • Antimicrobial coatings capable of reducing the number of murine norovirus inoculated thereon
    Patent number: 10463046
    Abstract: The present disclosure provides antimicrobial coatings on a surface comprising a reactive silanol and triethanolamine. In various examples the reactive silane is 3-chloropropylsilane triol. The coating is capable of reducing the number of Murine norovirus and E. Coli inoculated on the dried coating. In various examples, the coating further comprises a mixture of peroxotitanium acid and peroxo-modified anatase sol. The compositions may be electrostatically sprayed on the surface, and in certain examples, a mixture of silanol and triethanolamine is spray-coated on the surface followed by an aqueous mixture of peroxotitanium acid and peroxo-modified anatase sol.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: November 5, 2019
    Assignee: Allied Bioscience, Inc.
    Inventors: Daniel Moros, Craig Grossman
  • Hydrazinyl-pyrrolo compounds and methods for producing a conjugate
    Patent number: 10464894
    Abstract: The present disclosure provides conjugate structures and hydrazinyl-pyrrolo compound structures used to produce these conjugates. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: November 5, 2019
    Assignee: Redwood Biosciences, Inc.
    Inventors: David Rabuka, Aaron Edward Albers, Romas Alvydas Kudirka, Albert W. Garofalo
  • METHODS FOR OBTAINING STERILE MILK AND COMPOSITIONS THEREOF
    Publication number: 20190327994
    Abstract: The disclosure provides a simple and effective methods for sterilization of milk without degradation or loss of biologically active agents in the milk and the products produced by such methods.
    Type: Application
    Filed: July 8, 2019
    Publication date: October 31, 2019
    Applicant: Prolacta Bioscience, Inc.
    Inventors: Elena M. MEDO, Armando MONTOYA, Martin LEE, David RECHTMAN
  • Engineered cascade components and cascade complexes
    Patent number: 10457922
    Abstract: The present disclosure provides engineered Class 1 Type I CRISPR-Cas (Cascade) systems that comprise multi-protein effector complexes, nucleoprotein complexes comprising Type I CRISPR-Cas subunit proteins and nucleic acid guides, polynucleotides encoding Type I CRISPR-Cas subunit proteins, and guide polynucleotides. Also, disclosed are methods for making and using the engineered Class 1 Type I CRISPR-Cas systems of the present invention.
    Type: Grant
    Filed: May 22, 2019
    Date of Patent: October 29, 2019
    Assignee: Caribou Biosciences, Inc.
    Inventors: Peter Sean Cameron, Sanne Eveline Klompe, Samuel Henry Sternberg
  • Treatment of clostridium difficile infection
    Patent number: 10456431
    Abstract: Provided herein are compositions and methods for the treatment or prevention of pathogenic infections.
    Type: Grant
    Filed: October 11, 2018
    Date of Patent: October 29, 2019
    Assignee: Vedanta Biosciences, Inc.
    Inventors: Jessica Schneider, Yun-Gi Kim, Bernat Olle, Shilpa Reddy, Jason Norman, Juan Patarroyo
  • Infection control apparatus
    Patent number: 10456493
    Abstract: An apparatus is provided for controlling hospital acquired infections by targeting critical control points for pathogen transfer. An infection control apparatus comprises an asset tagging unit; a spraying unit; a power supply unit; optionally a DNA/RNA sequencing unit; and a computing unit comprising a non-transitory computer-readable medium encoded with program instructions for controlling the asset tagging unit and the spraying unit to perform a method of infection control in the facility. In general, the apparatus is used to identify which assets are critical control points for pathogen transfer and to treat those assets with a residual self-sanitizing coating.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: October 29, 2019
    Assignee: Allied Bioscience, Inc.
    Inventors: Craig Grossman, Ingrida Grossman, Gavri Grossman
  • METHODS, APPARATUSES, AND SYSTEMS FOR MICROORGANISM STRAIN ANALYSIS OF COMPLEX HETEROGENEOUS COMMUNITIES WITH TRACER ANALYTICS, DETERMINATION OF FUNCTIONAL RELATIONSHIPS AND INTERACTIONS THEREOF, AND SYNTHESIS OF MICROBIAL ENSEMBLES
    Publication number: 20190323055
    Abstract: Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities with tracer analytics, determination of functional relationships and interactions thereof, and synthesis of microbial ensembles, including dosed microbial ensembles and inoculative microbial ensembles, are disclosed.
    Type: Application
    Filed: December 28, 2017
    Publication date: October 24, 2019
    Applicant: Ascus Biosciences, Inc.
    Inventor: Mallory EMBREE
  • ITERATIVE FEATURE SELECTION METHODS
    Publication number: 20190325310
    Abstract: Feature selection methods and processes that facilitate reduction of model components available for iterative modeling. It has been discovered that methods of eliminating model components that do not meaningfully contribute to a solution can be preliminarily discovered and discarded, thereby dramatically decreasing computational requirements in iterative programming techniques. This development unlocks the ability of iterative modeling to be used to solve complex problems that, in the past, would have required computation time on orders of magnitude too great to be useful.
    Type: Application
    Filed: July 1, 2019
    Publication date: October 24, 2019
    Applicant: Liquid Biosciences, Inc.
    Inventor: Patrick Lilley
  • Cow food and methods of husbandry for increased milk production
    Patent number: 10448657
    Abstract: The disclosure relates to animal food and methods for increasing the amount of milk and/or milk components produced by a ruminant animal, such as a cow. Particularly, the disclosure provides a cow food comprising microorganisms, such as a Pichia sp. and a Clostridium sp.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: October 22, 2019
    Assignee: Ascus Biosciences, Inc.
    Inventors: Mallory Embree, Luke Picking, Grant Gogul, Janna Tarasova
  • Cow food and methods of husbandry for increased milk production
    Patent number: 10448658
    Abstract: The disclosure relates to animal food and methods for shifting rumen microbiome in a ruminant animal, such as a cow. Particularly, the disclosure provides a cow food comprising microorganisms, such as a Pichia sp. and a Clostridium sp.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: October 22, 2019
    Assignee: Ascus Biosciences, Inc.
    Inventors: Mallory Embree, Luke Picking, Grant Gogul, Janna Tarasova
  • High-flow fluid valve block
    Patent number: 10451188
    Abstract: An illustrative valve block includes a pressure plate, a fluid transfer block, and a diaphragm. The pressure plate includes a pressure channel configured to receive a pressurized first fluid and a recess in a surface of the pressure plate. The pressure channel and the recess are fluidly connected. The fluid transfer block includes an inlet connection configured to receive a second fluid and an outlet connection. The fluid transfer block also includes a plurality of valve inlet bores each fluidly connected to the inlet connection. The plurality of valve inlet bores are distributed along at least part of a first circular shape. The fluid transfer block further includes a plurality of valve outlet bores each fluidly connected to the outlet connection.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: October 22, 2019
    Assignee: Semba Biosciences, Inc.
    Inventors: Brian A. Harbrecht, Robert Charles Mierendorf, Scott G. Manke
  • Transcriptional regulation for improved plant productivity
    Patent number: 10450580
    Abstract: Methods comprising DNA constructs and polynucleotides of functional transcription factors for improving photosynthetic capacity, biomass and/or grain yield and stress tolerance in various crop and model plants, dicots and monocots with the C3 or C4 photosynthetic pathways are described herein.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: October 22, 2019
    Assignee: Yield10 Bioscience, Inc.
    Inventors: Madana M.R. Ambavaram, Mariya Somleva
  • Etanercept Formulations Stabilized with Sodium Chloride
    Publication number: 20190314499
    Abstract: The invention provides stabilized aqueous pharmaceutical etanercept compositions suitable for long-term storage of etanercept, methods of manufacture of these compositions, methods of administration, and kits containing same.
    Type: Application
    Filed: June 26, 2019
    Publication date: October 17, 2019
    Applicant: Coherus Biosciences, Inc.
    Inventors: Mark MANNING, Brian Murphy
  • REAGENT CARTRIDGE FOR DETECTION OF CELLS
    Publication number: 20190316168
    Abstract: An apparatus includes a housing and an actuator. The housing, which defines a reagent volume that can receive a reagent container, can be removably coupled to a reaction chamber. A delivery portion of the housing defines a delivery path between the reagent volume and the reaction chamber when the housing is coupled to the reaction chamber. The delivery path includes a protrusion such that the delivery path has a discontinuous inner surface. The actuator can be moved to convey a reagent from the reagent container into the reaction chamber via the delivery path.
    Type: Application
    Filed: June 27, 2019
    Publication date: October 17, 2019
    Applicant: GeneWeave Biosciences, Inc.
    Inventors: Doran DONNELLY, Werner FREI, Ryan GRISWOLD, Lance PAGE, Shaunak ROY
  • Etanercept Formulations Stabilized with Sodium Chloride
    Publication number: 20190314500
    Abstract: The invention provides stabilized aqueous pharmaceutical etanercept compositions suitable for long-term storage of etanercept, methods of manufacture of these compositions, methods of administration, and kits containing same.
    Type: Application
    Filed: June 27, 2019
    Publication date: October 17, 2019
    Applicant: Coherus Biosciences, Inc.
    Inventors: Mark MANNING, Brian Murphy
  • Etanercept Formulations Stabilized with Sodium Chloride
    Publication number: 20190314498
    Abstract: The invention provides stabilized aqueous pharmaceutical etanercept compositions suitable for long-term storage of etanercept, methods of manufacture of these compositions, methods of administration, and kits containing same.
    Type: Application
    Filed: June 26, 2019
    Publication date: October 17, 2019
    Applicant: Coherus Biosciences, Inc.
    Inventors: Mark MANNING, Brian MURPHY