Patents Assigned to Bioscience, Inc.
  • Patent number: 9895436
    Abstract: Herpes Simplex Virus-2 (HSV-2) infection is a major health concern. The present disclosure provides, inter alia, certain highly effective vaccines and immunogenic compositions against HSV-2. The antigens can be used therapeutically or prophylactically.
    Type: Grant
    Filed: November 12, 2013
    Date of Patent: February 20, 2018
    Assignee: Genocea Biosciences, Inc.
    Inventors: Deborah Long, Jessica Flechtner, Mojca Skoberne, George R. Siber
  • Patent number: 9895356
    Abstract: Methods of treating a TRPC5 mediated disorder in a subject by administering an effective amount of a TRPC5 antagonist, such as a compound disclosed herein, are described.
    Type: Grant
    Filed: August 27, 2015
    Date of Patent: February 20, 2018
    Assignee: Hydra Biosciences, Inc.
    Inventors: Jayhong A. Chong, Christopher Fanger, Magdalene M. Moran, Elisha Singer, Timothy Strassmaier, Howard Ng
  • Patent number: 9896724
    Abstract: Provided herein are optimized methods for performing multiplexed detection of a plurality of sequence variations. Also provided are methods for performing multiplexed amplification of target nucleic acid.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: February 20, 2018
    Assignee: Agena Bioscience, Inc.
    Inventors: Martin Beaulieu, Dirk Johannes van den Boom
  • Publication number: 20180042255
    Abstract: The present invention relates to a method for treating raw human milk to produce treated human milk having undetectable levels of bacteria. The milk is skimmed to produce skim human milk then subjected to microfiltration to yield a filtrate which has undetectable levels of bacteria, including Bacillus cereus. The resultant human milk can be further processed, used and/or sold.
    Type: Application
    Filed: October 17, 2017
    Publication date: February 15, 2018
    Applicant: Prolacta Bioscience, Inc.
    Inventors: Joseph FOURNELL, Scott EAKER, Armando MONTOYA
  • Publication number: 20180043023
    Abstract: Disclosed are synthetic nanocarrier compositions with coupled adjuvant compositions as well as related methods.
    Type: Application
    Filed: August 23, 2017
    Publication date: February 15, 2018
    Applicant: Selecta Biosciences, Inc.
    Inventors: Petr Ilyinskii, Grayson B. Lipford, Charles Zepp
  • Publication number: 20180044712
    Abstract: Methods, apparatuses, and systems for screening, analyzing and selecting microorganisms from complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and synthesizing microbial ensembles based thereon are disclosed. Methods for identifying and determining the absolute cell count of microorganism types and strains, along with identifying the network relationships between active microorganisms and environmental parameters, are also disclosed.
    Type: Application
    Filed: October 23, 2017
    Publication date: February 15, 2018
    Applicant: Ascus Biosciences, Inc.
    Inventor: Mallory EMBREE
  • Patent number: 9889160
    Abstract: Disclosed herein is a genetically-modified cell comprising in its genome a modified human T cell receptor alpha constant region gene, wherein the cell has reduced cell-surface expression of the endogenous T cell receptor. The present disclosure further relates to methods for producing such a genetically-modified cell, and to methods of using such a cell for treating a disease in a subject.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: February 13, 2018
    Assignee: Precision BioSciences, Inc.
    Inventors: Derek Jantz, James Jefferson Smith, Michael G. Nicholson, Daniel T. MacLeod, Victor Bartsevich, Jeyaraj Antony
  • Patent number: 9889210
    Abstract: Methods for introducing nucleic acids to cells via exosomes for use in gene modulation and therapy, such as for gene silencing and to introduce genetic material into cells to compensate for abnormal genes or to induce or repress a process in the recipient cell.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: February 13, 2018
    Assignee: Codiak BioSciences, Inc.
    Inventors: Jan Lötvall, Hadi Valadi
  • Patent number: 9889161
    Abstract: Disclosed herein is a genetically-modified cell comprising in its genome a modified human T cell receptor alpha constant region gene, wherein the cell has reduced cell-surface expression of the endogenous T cell receptor. The present disclosure further relates to methods for producing such a genetically-modified cell, and to methods of using such a cell for treating a disease in a subject.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: February 13, 2018
    Assignee: Precision BioSciences, Inc.
    Inventors: Derek Jantz, James Jefferson Smith, Michael G. Nicholson, Daniel T. MacLeod, Victor Bartsevich, Jeyaraj Antony
  • Publication number: 20180040120
    Abstract: In accordance with the embodiment described herein, we describe a method for evaluating muscle fiber nuclei and non-muscle fiber mononuclear cells, and biomarkers expressed within these and muscle fibers, within the context of muscle tissue using digital tissue image analysis. An algorithm process is applied to histologically stained tissue sections to extract the morphometric, staining, and localization features of a plurality of tissue objects. These features can be further analyzed to describe relationships between tissue objects or tissue object image analysis features. One or more of these image analysis features or relationships between objects and features are summarized to derive a patient-specific score. Patient stratification criteria are applied to the patient-specific score and patient strata membership is evaluated to infer presence of disease, natural course of disease, disease severity, treatment efficacy, or response to a therapy and eligibility for said therapy.
    Type: Application
    Filed: July 27, 2016
    Publication date: February 8, 2018
    Applicant: Flagship Biosciences, Inc.
    Inventors: Crystal Dawn Faelan, Anthony J. Milici, Joshua C. Black, Nathan T. Martin
  • Patent number: 9884112
    Abstract: This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: February 6, 2018
    Assignee: Selecta Biosciences, Inc.
    Inventors: Charles Zepp, Grayson B. Lipford, Yun Gao, Lloyd Johnston, Fen-ni Fu, Mark J. Keegan, Sam Baldwin
  • Patent number: 9884124
    Abstract: The invention provides carriers that enhance the absorption, half-life or bioavailability of therapeutic compounds. The carriers comprise targeting groups that bind the Vitamin D Binding protein (DBP), conjugation groups for coupling the targeting groups to the therapeutic compounds, and optionally scaffolding moieties.
    Type: Grant
    Filed: February 6, 2016
    Date of Patent: February 6, 2018
    Assignee: Extend Biosciences, Inc.
    Inventors: Tarik Soliman, Laura M. Hales, Howard P. Sard, Mukkanti Amere
  • Patent number: 9885026
    Abstract: A clustered regularly interspaced short palindromic repeat (CRISPR)-associated complex for adaptive antiviral defence (Cascade); the Cascade protein complex comprising at least CRISPR-associated protein subunits Cas7, Cas5 and Cas6 which includes at least one subunit with an additional amino acid sequence possessing nucleic acid or chromatin modifying, visualizing, transcription activating or transcription repressing activity. The Cascade complex with additional activity is combined with an RNA molecule to produce a ribonucleoprotein complex. The RNA molecule is selected to have substantial complementarity to a target sequence. Targeted ribonucleoproteins can be used as genetic engineering tools for precise cutting of nucleic acids in homologous recombination, non-homologous end joining, gene modification, gene integration, mutation repair or for their visualization, transcriptional activation or repression.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: February 6, 2018
    Assignee: Caribou Biosciences, Inc.
    Inventors: Stan Johan Jozef Brouns, John Van Der Oost
  • Publication number: 20180028655
    Abstract: The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these compositions, methods of administration, and kits containing same.
    Type: Application
    Filed: October 11, 2017
    Publication date: February 1, 2018
    Applicant: Coherus Biosciences, Inc.
    Inventors: Mark Manning, Robert W. Payne
  • Patent number: 9879313
    Abstract: The present disclosure provides methods and assay systems for use in spatially encoded biological assays, including assays to determine a spatial pattern of abundance, expression, and/or activity of one or more biological targets across multiple sites in a sample. In particular, the biological targets comprise proteins, and the methods and assay systems do not depend on imaging techniques for the spatial information of the targets. The present disclosure provides methods and assay systems capable of high levels of multiplexing where reagents are provided to a biological sample in order to address tag the sites to which reagents are delivered; instrumentation capable of controlled delivery of reagents; and a decoding scheme providing a readout that is digital in nature.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: January 30, 2018
    Assignee: Prognosys Biosciences, Inc.
    Inventors: Mark S. Chee, David A. Routenberg
  • Patent number: 9879249
    Abstract: The disclosure provides aldehyde-tagged protein carriers that can be covalently and site-specifically bound to drug to provide a drug-containing scaffold. The invention also encompasses methods of production of such drug-containing scaffolds and intermediates, as well as methods of use.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: January 30, 2018
    Assignee: Redwood Bioscience, Inc.
    Inventors: David Rabuka, Mark Alan Breidenbach
  • Patent number: 9879328
    Abstract: Disclosed herein are methods and compositions for determining the presence or absence of a mechanism of antimicrobial resistance in a sample.
    Type: Grant
    Filed: May 23, 2016
    Date of Patent: January 30, 2018
    Assignee: GeneWeave Biosciences, Inc.
    Inventors: Diego Ariel Rey, Micah Bodner, Jeremiah Marsden
  • Patent number: 9879075
    Abstract: The present invention mainly addresses the problem of providing an antibody against semaphorin 3A protein, said antibody enabling effective prevention and/or treatment of a disease, in which Sema 3A protein participates, such as a neurodegenerative disease, autoimmune disease, inflammatory disease, cancer, infectious disease, etc. or disseminated intravascular coagulation syndrome. An anti-Sema 3A antibody comprising CDRs having specific amino acid sequences (SEQ ID NOS: 1-6, 60-62, 64-66, 68-70, 72-74, 76-78, 80-82, 84-86 and 88-90) enables effective prevention and/or treatment of a disease, in which Sema 3A protein participates, such as a neurodegenerative disease, autoimmune disease, inflammatory disease, cancer, infectious disease, etc. or disseminated intravascular coagulation syndrome and, therefore, remarkably ameliorates symptoms associated with such a disease.
    Type: Grant
    Filed: February 6, 2014
    Date of Patent: January 30, 2018
    Assignee: Yokohama City University and Chiome Bioscience Inc.
    Inventors: Yoshio Goshima, Fumio Nakamura, Naoya Yamashita, Hidetaka Seo, Shuichi Hashimoto, Koji Murakami, Naoki Takahashi, Yukie Sasakura
  • Publication number: 20180021251
    Abstract: Pharmaceutical formulations and methods useful for the treatment of anorexia and the stimulation of appetite and weight gain, and the management of weight loss in dogs and cats.
    Type: Application
    Filed: February 26, 2016
    Publication date: January 25, 2018
    Applicant: Kindred Biosciences, Inc.
    Inventors: William Buhles, Richard Cortez, Kristin Maas, Geeta Srivastava, Daniel Perez
  • Patent number: 9873870
    Abstract: Methods and compositions for identifying antigens of human lymphocytes are provided herein.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: January 23, 2018
    Assignee: Genocea Biosciences, Inc.
    Inventors: Jessica Flechtner, Todd Gierahn