Patents Assigned to Biosearch Technologies, Inc.
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Patent number: 8119781Abstract: The present invention provides luminescent metal ion complexes for use in a wide range of biological and chemical studies. The luminescent metal ion complexes of the invention comprise a metal ion chelating component covalently bound to a carrier molecule. Also provided are methods of making and using the luminescent metal ion complexes.Type: GrantFiled: December 21, 2009Date of Patent: February 21, 2012Assignee: Biosearch Technologies, Inc.Inventors: Ronald M. Cook, Matt Lyttle, Mary Katherine Johannson
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Publication number: 20110294118Abstract: The invention provides a novel class of fluorescent compounds. Also provided are conjugates of the fluorescent compounds, methods of using the fluorescent compounds and their conjugates as well as kits including the fluorescent compounds and their conjugates.Type: ApplicationFiled: November 29, 2010Publication date: December 1, 2011Applicant: BIOSEARCH TECHNOLOGIES, INC.Inventor: MARK REDDINGTON
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Publication number: 20110282041Abstract: The present invention provides a new class of solids supports for synthesis of modified oligomers of nucleic acids, and nucleic acid probes that have a format expediently synthesized on the new supports. Exemplary solid supports include at least one quencher bound through a linker to the solid support. Various exemplary embodiments include a moiety that stabilizes a duplex, triplex or higher order aggregation (e.g., hybridization) of nucleic acids of which the oligomer of the invention is a component. Other components of the solid support include moieties that stabilize aggregations of nucleic acids, e.g., intercalators, minor groove binding moieties, bases modified with a stabilizing moiety (e.g., alkynyl moieties, and fluoroalkyl moieties), and conformational stabilizing moieties, such as those described in commonly owned U.S. Patent Application Publication No. 2007/0059752.Type: ApplicationFiled: July 28, 2011Publication date: November 17, 2011Applicant: Biosearch Technologies, Inc.Inventors: Ronald M. Cook, Matt Lyttle
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Publication number: 20110178280Abstract: The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.Type: ApplicationFiled: August 6, 2010Publication date: July 21, 2011Applicant: BIOSEARCH TECHNOLOGIES, INC.Inventors: RONALD M. COOK, MATT LYTTLE, DAREN DICK
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Publication number: 20110092679Abstract: The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.Type: ApplicationFiled: April 22, 2010Publication date: April 21, 2011Applicant: Biosearch Technologies, Inc.Inventors: Ronald M. Cook, Matt Lyttle, Daren Dick
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Publication number: 20110054165Abstract: The invention provides a novel class of xanthene dyes, some of which are functionalized to allow their coupling to conjugation partners of interest, e.g. biomolecules, drugs, toxins and the like. Also provided are conjugates of the dyes, methods of preparing and using the dyes and their conjugates and kits including the dyes and their conjugates.Type: ApplicationFiled: November 8, 2010Publication date: March 3, 2011Applicant: BIOSEARCH TECHNOLOGIES, INC.Inventors: MARK REDDINGTON, MATT LYTTLE
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Patent number: 7868157Abstract: The invention provides a novel class of fluorescent compounds. Also provided are conjugates of the fluorescent compounds, methods of using the fluorescent compounds and their conjugates as well as kits including the fluorescent compounds and their conjugates.Type: GrantFiled: July 7, 2006Date of Patent: January 11, 2011Assignee: Biosearch Technologies, Inc.Inventor: Mark Reddington
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Publication number: 20100136567Abstract: The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.Type: ApplicationFiled: January 5, 2010Publication date: June 3, 2010Applicant: Biosearch Technologies, Inc.Inventors: Tim Carter, Mark Reddington
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Publication number: 20100130733Abstract: The present invention provides luminescent metal ion complexes for use in a wide range of biological and chemical studies. The luminescent metal ion complexes of the invention comprise a metal ion chelating component covalently bound to a carrier molecule. Also provided are methods of making and using the luminescent metal ion complexes.Type: ApplicationFiled: December 21, 2009Publication date: May 27, 2010Applicant: BIOSEARCH TECHNOLOGIES, INC.Inventors: RONALD M. COOK, MATT LYTTLE, MARY KATHERINE JOHANNSON
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Patent number: 7705150Abstract: The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.Type: GrantFiled: February 4, 2005Date of Patent: April 27, 2010Assignee: Biosearch Technologies, Inc.Inventors: Tim Carter, Mark Reddington
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Publication number: 20100021922Abstract: The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.Type: ApplicationFiled: August 25, 2009Publication date: January 28, 2010Applicant: Biosearch Technologies, Inc.Inventors: Ronald M. Cook, Matt Lyttle, Daren Dick
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Patent number: 7635598Abstract: In one aspect, the invention provides fluorescent probes and assays. The probes include a fluorophore-quencher pair that undergoes a switch from dark to fluorescent in response to a reaction of the quencher. The switch of the probe from dark to fluorescent is typically mediated by an enzyme that acts directly or indirectly on the quencher, interfering with its ability to quench fluorescence emission from the fluorophore. In another aspect, the invention provides a reporter gene assay system and methods of using this system. The assay system includes a fluorophore-quencher probe and an enzyme that acts directly or indirectly on the quencher, increasing the fluorescent emission of the fluorophore. In still other aspects, the invention provides nucleic acid constructs and cells expressing the peptide products of these constructs. In assays of the invention, the presence of a target substance is detected by the switching of fluorescence mediated by the change in oxidation state of the quencher.Type: GrantFiled: July 8, 2005Date of Patent: December 22, 2009Assignee: Biosearch Technologies, Inc.Inventors: Ronald M. Cook, Eliana Saxon Armstrong, Hans E. Johansson
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Patent number: 7635762Abstract: The present invention provides luminescent metal ion complexes for use in a wide range of biological and chemical studies. The luminescent metal ion complexes of the invention comprise a metal ion chelating component covalently bound to a carrier molecule. Also provided are methods of making and using the luminescent metal ion complexes.Type: GrantFiled: October 21, 2003Date of Patent: December 22, 2009Assignee: Biosearch Technologies, Inc.Inventors: Ronald M. Cook, Matt Lyttle, Mary Katherine Johansson
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Patent number: 7582432Abstract: The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.Type: GrantFiled: May 19, 2006Date of Patent: September 1, 2009Assignee: Biosearch Technologies, Inc.Inventors: Ronald M. Cook, Matt Lyttle, Daren Dick
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Publication number: 20080214811Abstract: The invention provides a novel class of xanthene dyes, some of which are functionalized to allow their coupling to conjugation partners of interest, e.g. biomolecules, drugs, toxins and the like. Also provided are conjugates of the dyes, methods of preparing and using the dyes and their conjugates and kits including the dyes and their conjugates.Type: ApplicationFiled: February 25, 2008Publication date: September 4, 2008Applicant: Biosearch Technologies, Inc.Inventors: Mark Reddington, Matt Lyttle
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Patent number: 7344701Abstract: The invention provides a novel class of xanthene dyes, some of which are functionalized to allow their coupling to conjugation partners of interest, e.g. biomolecules, drugs, toxins and the like. Also provided are conjugates of the dyes, methods of preparing and using the dyes and their conjugates and kits including the dyes and their conjugates.Type: GrantFiled: April 13, 2004Date of Patent: March 18, 2008Assignee: Biosearch Technologies, Inc.Inventors: Mark Reddington, Matt Lyttle
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Publication number: 20070154898Abstract: The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.Type: ApplicationFiled: May 19, 2006Publication date: July 5, 2007Applicant: Biosearch Technologies, Inc.Inventors: Ronald Cook, Matt Lyttle, Daren Dick
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Publication number: 20070059752Abstract: The present invention provides a class of Conformationally Assisted Probes comprising (a) a nucleic acid moiety; (b) an energy donor moiety; (c) an energy acceptor moiety; and (d) one or more stabilizing moieties.Type: ApplicationFiled: September 13, 2006Publication date: March 15, 2007Applicant: Biosearch Technologies, Inc.Inventor: Ronald Cook
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Publication number: 20070021621Abstract: The invention provides a novel class of fluorescent compounds. Also provided are conjugates of the fluorescent compounds, methods of using the fluorescent compounds and their conjugates as well as kits including the fluorescent compounds and their conjugates.Type: ApplicationFiled: July 7, 2006Publication date: January 25, 2007Applicant: Biosearch Technologies, Inc.Inventor: Mark Reddington
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Patent number: 7109312Abstract: The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.Type: GrantFiled: July 29, 2005Date of Patent: September 19, 2006Assignee: Biosearch Technologies, Inc.Inventors: Ronald M. Cook, Matt Lyttle, Daren Dick