Patents Assigned to Biosensor, LLC
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Patent number: 11931138Abstract: A hydrogel sensor device can include a crosslinked hydrogel body which changes in volume in response to an environmental stimulus, a support post positioned to mechanically support the crosslinked hydrogel body during the change in volume, and a sensor positioned to detect the change in volume in the crosslinked hydrogel body.Type: GrantFiled: December 14, 2018Date of Patent: March 19, 2024Assignee: Applied Biosensors, LLCInventors: Prashant Tathireddy, Rohit Sharma, Seung Hei Cho, Nicholas Frazier, Yoonsung Goo
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Patent number: 10752873Abstract: A sensor, especially for a reactor, bioreactor, or a clinical or animal research application, is disclosed including a sensor probe having at least one sensor unit associated therewith, each sensor unit including a hydrogel, a magnetic sheet disposed on one side of the hydrogel, and a magnetometer disposed on a side of the hydrogel opposite the magnetic sheet.Type: GrantFiled: January 26, 2016Date of Patent: August 25, 2020Assignee: Applied Biosensors, LLCInventors: Vishal Bhola, Prashant Tathireddy
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Patent number: 9835614Abstract: System and Method for measuring the growth of a bacterial culture and its response to one or more antimicrobials using measurement of mass of individual microbes. Methods include periodic sampling, determining change in mass and concentration, and comparing growth rates of cultures in nutrient broth vs. mixtures containing various antibiotic mixtures. A number of antimicrobials can be compared in one measurement by multiplexing or using multiple sensors to measure in parallel. Growth and antibiotic efficacy can be assessed at low concentrations at the onset of growth, typically within 1 to 2 hours.Type: GrantFiled: September 8, 2014Date of Patent: December 5, 2017Assignee: Affinity Biosensors, LLCInventors: Ken Babcock, Cynthia Schneider
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Patent number: 9581569Abstract: Methods for improving measurements of bacterial growth, such as mass, in Suspended Microchannel Resonators (SMR's). Methods include techniques to provide for bacterial growth over time in response to changing fluid environment to aid in determining parameters such as drug resistance and drug susceptibility. In particular the methods include trapping multiple bacteria in the SMR for a time period and varying the fluid to include sequences of nutrients and antibiotics, and measuring the rate of mass change of the bacteria in response to the changes in fluid composition.Type: GrantFiled: January 12, 2012Date of Patent: February 28, 2017Assignee: Affinity Biosensors, LLCInventors: Kenneth Babcock, Scott R. Manalis
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Publication number: 20160183607Abstract: A protective clothing article including a wearable member placeable over the torso of a user, includes an upper portion for engaging the user's shoulders, and a lower portion disposed, when worn by the user, at a vertical position generally similar to the pelvis of the user. At least two deployable airbags are disposed on the lower portion of the clothing article at a vertical position generally similar to the pelvis of a user. A compressed air source is provided for injecting air into the air bags upon deployment of the air bags to inflate the airbags. The clothing article also includes at least two sensors capable of detecting and sensing information relating to the direction and velocity of movement of the user.Type: ApplicationFiled: February 11, 2015Publication date: June 30, 2016Applicant: Biosensor, LLCInventors: Alfredo Lopez Yunez, Diana Vasquez Torres, Ajay Kumar Bandi
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Patent number: 9027388Abstract: Method for measuring a target particle property. A suspended microchannel resonator is calibrated to determine the relationship between a detected mass and a resonance frequency shift of the resonator. The target particle is suspended in a fluid and introduced into the resonator, and the resonator frequency shift due to the particle is measured. Target particle mass is calculated from the resonator frequency shift, the target particle density, and the fluid density. A target particle property such as size or volume is determined from the calculated target particle mass.Type: GrantFiled: December 4, 2011Date of Patent: May 12, 2015Assignees: Affinity Biosensors, LLC, Massachusetts Institute of TechnologyInventors: Kenneth Babcock, Thomas Burg, Michel Godin, Scott Manalis
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Publication number: 20140235489Abstract: An integrated microelectronic sensor is provided in a disposable flow membrane sensing device. The integrated sensors detect electromagnetic effect labels in flow detection zones above the sensor in the membrane. The labels are small particles that give off a detectable electromagnetic signal. They are commonly used for isolating and quantifying biochemical targets of interest. The sensors are fabricated using planar integrated circuit technologies. Sensors can detect labels of several types including magnetic, electric, and photonic. These types all have in common the fact that the sensor detects the label at a distance. Magnetoresistive sensors for detecting magnetic labels, and photodiodes for detecting photonic labels are described. A system for using the sensors is described. There are disposable cartridges with a backing that supports the sensors and membrane is described. The integrated sensor in the cartridge is designed to be discarded after use. Also, label excitation sources are provided.Type: ApplicationFiled: April 30, 2014Publication date: August 21, 2014Applicant: Diagnostic Biosensors, LLCInventor: Mark Christopher Tondra
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Patent number: 8753894Abstract: An integrated microelectronic sensor is provided in a disposable flow membrane sensing device. The integrated sensors detect electromagnetic effect labels in flow detection zones above the sensor in the membrane. The labels are small particles that give off a detectable electromagnetic signal. They are commonly used for isolating and quantifying biochemical targets of interest. The sensors are fabricated using planar integrated circuit technologies. Sensors can detect labels of several types including magnetic, electric, and photonic. These types all have in common the fact that the sensor detects the label at a distance. Magnetoresistive sensors for detecting magnetic labels, and photodiodes for detecting photonic labels are described. A system for using the sensors is described. There are disposable cartridges with a backing that supports the sensors and membrane is described. The integrated sensor in the cartridge is designed to be discarded after use. Also, label excitation sources are provided.Type: GrantFiled: February 1, 2008Date of Patent: June 17, 2014Assignee: Diagnostic Biosensors, LLCInventor: Mark Christopher Tondra