Abstract: A sensor for detecting analytes of interest is described. Analyte presence or concentration is determined through measurement of changes in induced electromotive force, current or other electrical property in a sensor strip during analyte exposure to the sensor. According to one class of embodiments, the present device immobilizes natural or synthetic macromolecules sufficiently close to an electrically-conductive base member to insure that interaction of analyte with the macromolecules will lead to altered de novo electrical signals in the sensor strip of base member and macromolecules. Performance of the sensor is enhanced by the use of resistance-modifying element in a circuit that includes the sensor strip, and by an adhesive agent disposed between the base member and at least one electrical lead of a detection unit.

Abstract: The present invention relates to a sensor for analyte detection. The sensor makes use of changes in electrostatic fields associated with macromolecular binding agents during their interaction with analytes. Specifically, analyte presence leads to increases in magnetic flux generated by the motions of the binding agent electrostatic material. Magnetic or induced electrical signals may be monitored for change in order to detect analyte in a sample of interest.

Abstract: A sensor for detecting analytes is described. Analyte presence or concentration is determined through measurement of changes in induced electromotive force, current or other electrical property in a base member during analyte exposure to the sensor. According to one class of embodiments, the present device immobilizes natural or synthetic macromolecules sufficiently close to an electrically-conductive base member to insure that any alteration in the motion and/or electrostatic fields of the macromolecules during interaction with a predetermined analyte will induce an increased electromotive force in the base member.

Abstract: The device described herein is an enzyme-based biosensor for detecting and/or quantifying molecules of interest. The biosensor relies on the following properties shared by all enzymes: (1) that enzymes are highly specific molecules designed to bind with only one analyte type or one class of analyte molecules; (2) that enzymes contain charges; (3) that enzymes undergo significant spacial fluctuation during periods of interaction with substrates; and (4) that these spacial fluctuations cause the charged moieties on the enzyme to move and thus generate a measurable electrostatic potential (voltage) in both the enzyme and support layers. The instant device determines analyte presence/concentration through measurement of changes in voltage or current in a conducting or semiconducting support material as a result of changes in the position of immobilized charged enzyme molecules during their interaction with analyte.