Abstract: Disclosed herein are compositions and methods for treating uterine fibroids in vivo, and methods of reducing symptoms associated with uterine fibroids, including pain, bleeding and infertility. The disclosed compositions comprise collagenase in an amount effective to cause shrinkage and/or reduce stiffness of uterine fibroids.
Type:
Grant
Filed:
October 14, 2020
Date of Patent:
January 16, 2024
Assignees:
The Johns Hopkins University, Duke University, BioSpecifics Technologies LLC
Inventors:
James H. Segars, Phyllis Carolyn Leppert, Thomas L. Wegman, Jean-Marie Soma
Abstract: Compositions and methods for treating uterine fibroids are described, wherein a uterine fibroid treatment agent comprising collagenase in an amount effective to cause shrinkage of uterine fibroids is injected or inserted into the uterine fibroid.
Type:
Grant
Filed:
April 5, 2021
Date of Patent:
January 2, 2024
Assignees:
BioSpecifics Technologies LLC, Duke University
Inventors:
Phyllis Carolyn Leppert, Thomas L. Wegman