Patents Assigned to Biosphere Medical, Inc.
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Publication number: 20140065233Abstract: The present invention relates to elastic, hydrophilic and substantially spherical microspheres useful for dermal augmentation and tissue bulking. The invention provides injectable compositions comprising the microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further provides methods of dermal augmentation and tissue bulking, particularly for the treatment of skin contour deficiencies, Gastro-esophageal reflux disease, urinary incontinence, and urinary reflux disease, using the injectable compositions.Type: ApplicationFiled: November 8, 2013Publication date: March 6, 2014Applicant: Biosphere Medical, Inc.Inventors: Jean-Marie Vogel, Richard Thomas, Egisto Boschetti
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Publication number: 20130323317Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres useful for tissue bulking. The invention also relates to methods of tissue bulking, particularly for the treatment of Gastro-esophageal reflux disease, urinary incontinence, or urinary reflux disease, using the injectable compositions.Type: ApplicationFiled: August 8, 2013Publication date: December 5, 2013Applicant: Biosphere Medical, Inc.Inventors: Jean-Marie Vogel, Richard Thomas, Egisto Boschetti
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Publication number: 20130323316Abstract: The present invention relates to elastic, hydrophilic and substantially spherical microspheres useful for dermal augmentation and tissue bulking. The invention provides injectable compositions comprising the microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further provides methods of dermal augmentation and tissue bulking, particularly for the treatment of skin contour deficiencies, Gastro-esophageal reflux disease, urinary incontinence, and urinary reflux disease, using the injectable compositions.Type: ApplicationFiled: August 7, 2013Publication date: December 5, 2013Applicant: Biosphere Medical, Inc.Inventors: Jean-Marie Vogel, Richard Thomas, Egisto Boschetti
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Publication number: 20130190795Abstract: The present invention relates to substantially compressible, spherical porous embolization particles, including methods of making and using the particles. Further, the invention relates to embolization delivery systems for the introduction of the particle into the vascular luer.Type: ApplicationFiled: December 17, 2012Publication date: July 25, 2013Applicant: BIOSPHERE MEDICAL, INC.Inventor: BIOSPHERE MEDICAL, INC.
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Publication number: 20120213831Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) for use in embolization drug therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions.Type: ApplicationFiled: May 2, 2012Publication date: August 23, 2012Applicant: BIOSPHERE MEDICAL, INC.Inventors: Jean-Marie Vogel, Egisto Boschetti
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Publication number: 20120141379Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) for use in embolization drug therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions.Type: ApplicationFiled: February 13, 2012Publication date: June 7, 2012Applicant: Biosphere Medical, Inc.Inventors: Jean-Marie Vogel, Egisto Boschetti
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Patent number: 8142815Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further relates to methods of dermal augmentation, particularly for the treatment of skin contour deficiencies, using the injectable compositions.Type: GrantFiled: August 17, 2004Date of Patent: March 27, 2012Assignee: BioSphere Medical, Inc.Inventors: Jean-Marie Vogel, Egisto Boschetti
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Publication number: 20110182998Abstract: Provided herein, for example, are microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Also provided are methods of producing microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Further provided herein, for example, are compositions comprising the microspheres and methods of using the microspheres and compositions thereof.Type: ApplicationFiled: January 26, 2011Publication date: July 28, 2011Applicants: Biosphere Medical, Inc., BioSphere Medical, SAInventors: Philippe Reb, Pierre Marion, Barbara De Gioannis, James Krom
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Publication number: 20110033508Abstract: The present invention relates to elastic, hydrophilic and substantially spherical microspheres useful for dermal augmentation and tissue bulking. The invention provides injectable compositions comprising the microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further provides methods of dermal augmentation and tissue bulking, particularly for the treatment of skin contour deficiencies, Gastro-esophageal reflux disease, urinary incontinence, and urinary reflux disease, using the injectable compositions.Type: ApplicationFiled: July 31, 2009Publication date: February 10, 2011Applicant: Biosphere Medical, Inc.Inventors: Jean-Marie VOGEL, Richard Thomas, Egisto Boschetti
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Publication number: 20090186094Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres useful for tissue bulking. The invention also relates to methods of tissue bulking, particularly for the treatment of Gastro-esophageal reflux disease, urinary incontinence, or urinary reflux disease, using the injectable compositions.Type: ApplicationFiled: August 22, 2008Publication date: July 23, 2009Applicant: BioSphere Medical, Inc.Inventors: Jean-Marie Vogel, Egisto Boschetti, Richard Thomas
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Publication number: 20090117196Abstract: The present invention relates to microspheres useful for embolization which comprises polyvinylalcohol. The present invention also relates to an injectable suspension suitable for embolization which comprises the polyvinylalcohol microspheres and a suitable liquid carrier. The present invention further relates to a method for prophylactic or therapeutic embolization which comprises administering to a mammal an injectable suspension containing the polyvinylalcohol microspheres and a suitable liquid carrier. Finally, the present invention relates to a process for producing the polyvinylalcohol microspheres.Type: ApplicationFiled: January 5, 2009Publication date: May 7, 2009Applicant: Biosphere Medical, Inc.Inventor: Egisto Boschetti
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Publication number: 20080220077Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) for use in embolization drug therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions.Type: ApplicationFiled: May 16, 2008Publication date: September 11, 2008Applicant: Biosphere Medical, Inc.Inventors: Jean-Marie Vogel, Egisto Boschetti
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Publication number: 20080118569Abstract: The present invention relates to injectable compositions comprising biocompatible, hydrophilic, non-toxic and substantially spherical microspheres associated with stem cells useful for tissue construction and generation. The invention also relates to methods of tissue construction and generation, for the treatment of various tissue damage and defects, using the injectable compositions.Type: ApplicationFiled: January 16, 2008Publication date: May 22, 2008Applicant: Biosphere Medical, Inc.Inventors: Jean-Marie Vogel, Egisto Boschetti
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Patent number: 7338657Abstract: The present invention relates to injectable compositions comprising biocompatible, hydrophilic, non-toxic and substantially spherical microspheres associated with stem cells useful for tissue construction and generation. The invention also relates to methods of tissue construction and generation, for the treatment of various tissue damage and defects, using the injectable compositions.Type: GrantFiled: March 15, 2001Date of Patent: March 4, 2008Assignee: BioSphere Medical, Inc.Inventors: Jean-Marie Vogel, Egisto Boschetti
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Patent number: 7135593Abstract: One aspect of the present invention relates to base-labile crosslinkers. A second aspect of the present invention relates to degradable crosslinked polymers and hydrogels comprising a base-labile crosslinker. The present invention also relates to a method of influencing the degradation rate of a crosslinked polymer or hydrogel, comprising the step of incorporating uncharged acrylamides into the crosslinked polymer or hydrogel.Type: GrantFiled: March 22, 2004Date of Patent: November 14, 2006Assignee: Biosphere Medical, Inc.Inventors: Hongmin Zhang, Alexander Schwarz
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Patent number: 7060298Abstract: The invention encompasses the treatment of urinary incontinence, gastroesophageal reflux disease and the amelioration of skin wrinkles using biocompatible hydrophilic cationic microparticles and a cell adhesion promoter.Type: GrantFiled: December 28, 2001Date of Patent: June 13, 2006Assignee: BioSphere Medical, Inc.Inventors: Jean Marie Vogel, Richard Thomas, Egisto Boschetti
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Publication number: 20060067883Abstract: One aspect of the present invention relates to a microsphere, comprising a hydrophilic polymer comprising a plurality of pendant anionic groups; a transition-metal, lanthanide or group 13-14 metal oxide, polyoxometalate or metal hydroxide or combination thereof; and a first radioisotope that emits a therapeutic ?-particle. In certain embodiments, the microsphere further comprsies a second radioisotope that emits a diagnostic ?-ray; wherein the atomic number of the first radioisotope is not the same as the atomic number of the second radioisotope. In certain embodiments, the microsphere is composed of polymer impregnated with zirconia bound to 32p as the source of the therapeutic ?-emissions and 67Ga as the source of the diagnostic ?-emissions.Type: ApplicationFiled: July 19, 2005Publication date: March 30, 2006Applicant: Biosphere Medical, Inc.Inventors: James Krom, Alexander Schwarz
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Patent number: 6790456Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further relates to methods of dermal augmentation, particularly for the treatment of skin contour deficiencies, using the injectable compositions.Type: GrantFiled: August 19, 2002Date of Patent: September 14, 2004Assignee: Biosphere Medical, Inc.Inventors: Jean-Marie Vogel, Egisto Boschetti
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Publication number: 20040096514Abstract: The present invention relates to elastic, hydrophilic and substantially spherical microspheres useful for dermal augmentation and tissue bulking. The invention provides injectable compositions comprising the microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further provides methods of dermal augmentation and tissue bulking, particularly for the treatment of skin contour deficiencies, Gastro-esophageal reflux disease, urinary incontinence, and urinary reflux disease, using the injectable compositions.Type: ApplicationFiled: November 12, 2003Publication date: May 20, 2004Applicant: BioSphere Medical, Inc.Inventors: Jean-Marie Vogel, Richard Thomas, Egisto Boschetti
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Patent number: 6660301Abstract: The present invention relates to elastic, hydrophilic and substantially spherical microspheres useful for dermal augmentation and tissue bulking. The invention provides injectable compositions comprising the microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further provides methods of dermal augmentation and tissue bulking, particularly for the treatment of skin contour deficiencies, Gastro-esophageal reflux disease, urinary incontinence, and urinary reflux disease, using the injectable compositions.Type: GrantFiled: March 20, 2000Date of Patent: December 9, 2003Assignee: Biosphere Medical, Inc.Inventors: Jean-Marie Vogel, Richard Thomas, Egisto Boschetti