Patents Assigned to Biosphere Medical
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Patent number: 7670592Abstract: The present invention relates to microspheres useful for embolization which comprises polyvinylalcohol. The present invention also relates to an injectable suspension suitable for embolization which comprises the polyvinylalcohol microspheres and a suitable liquid carrier. The present invention further relates to a method for prophylactic or therapeutic embolization which comprises administering to a mammal an injectable suspension containing the polyvinylalcohol microspheres and a suitable liquid carrier. Finally, the present invention relates to a process for producing the polyvinylalcohol microspheres.Type: GrantFiled: January 5, 2009Date of Patent: March 2, 2010Assignee: BioSphere Medical, S.A.Inventor: Egisto Boschetti
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Patent number: 7591993Abstract: The present invention relates to microspheres useful for embolization which comprises polyvinylalcohol. The present invention also relates to an injectable suspension suitable for embolization which comprises the polyvinylalcohol microspheres and a suitable liquid carrier. The present invention further relates to a method for prophylactic or therapeutic embolization which comprises administering to a mammal an injectable suspension containing the polyvinylalcohol microspheres and a suitable liquid carrier. Finally, the present invention relates to a process for producing the polyvinylalcohol microspheres.Type: GrantFiled: October 27, 2003Date of Patent: September 22, 2009Assignee: BioSphere Medical, S.A.Inventor: Egisto Boschetti
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Publication number: 20090186094Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres useful for tissue bulking. The invention also relates to methods of tissue bulking, particularly for the treatment of Gastro-esophageal reflux disease, urinary incontinence, or urinary reflux disease, using the injectable compositions.Type: ApplicationFiled: August 22, 2008Publication date: July 23, 2009Applicant: BioSphere Medical, Inc.Inventors: Jean-Marie Vogel, Egisto Boschetti, Richard Thomas
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Publication number: 20090117196Abstract: The present invention relates to microspheres useful for embolization which comprises polyvinylalcohol. The present invention also relates to an injectable suspension suitable for embolization which comprises the polyvinylalcohol microspheres and a suitable liquid carrier. The present invention further relates to a method for prophylactic or therapeutic embolization which comprises administering to a mammal an injectable suspension containing the polyvinylalcohol microspheres and a suitable liquid carrier. Finally, the present invention relates to a process for producing the polyvinylalcohol microspheres.Type: ApplicationFiled: January 5, 2009Publication date: May 7, 2009Applicant: Biosphere Medical, Inc.Inventor: Egisto Boschetti
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Publication number: 20080220077Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) for use in embolization drug therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions.Type: ApplicationFiled: May 16, 2008Publication date: September 11, 2008Applicant: Biosphere Medical, Inc.Inventors: Jean-Marie Vogel, Egisto Boschetti
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Publication number: 20080118569Abstract: The present invention relates to injectable compositions comprising biocompatible, hydrophilic, non-toxic and substantially spherical microspheres associated with stem cells useful for tissue construction and generation. The invention also relates to methods of tissue construction and generation, for the treatment of various tissue damage and defects, using the injectable compositions.Type: ApplicationFiled: January 16, 2008Publication date: May 22, 2008Applicant: Biosphere Medical, Inc.Inventors: Jean-Marie Vogel, Egisto Boschetti
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Patent number: 7338657Abstract: The present invention relates to injectable compositions comprising biocompatible, hydrophilic, non-toxic and substantially spherical microspheres associated with stem cells useful for tissue construction and generation. The invention also relates to methods of tissue construction and generation, for the treatment of various tissue damage and defects, using the injectable compositions.Type: GrantFiled: March 15, 2001Date of Patent: March 4, 2008Assignee: BioSphere Medical, Inc.Inventors: Jean-Marie Vogel, Egisto Boschetti
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Patent number: 7135593Abstract: One aspect of the present invention relates to base-labile crosslinkers. A second aspect of the present invention relates to degradable crosslinked polymers and hydrogels comprising a base-labile crosslinker. The present invention also relates to a method of influencing the degradation rate of a crosslinked polymer or hydrogel, comprising the step of incorporating uncharged acrylamides into the crosslinked polymer or hydrogel.Type: GrantFiled: March 22, 2004Date of Patent: November 14, 2006Assignee: Biosphere Medical, Inc.Inventors: Hongmin Zhang, Alexander Schwarz
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Publication number: 20060251582Abstract: The present invention relates to compositions and methods for treating diseases and disorders including cancer and various other angiogenic-dependent diseases, vascular malfunctions, arteriovenous malformations (AVM), hemorrhagic processes and treatment of pain, in particular tumor-related pain by drug delivery and/or therapeutic embolization using microspheres. More particularly the invention relates to microspheres containing non-ionic contrast agents, to compositions comprising these microspheres, as well as methods for preparing and using such compositions for embolization therapy. The invention further relates to compositions and methods using detectable microspheres for targeted drug delivery, irrespective of whether embolization is also needed.Type: ApplicationFiled: May 9, 2006Publication date: November 9, 2006Applicant: BioSphere Medical SAInventor: Philippe Reb
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Patent number: 7060298Abstract: The invention encompasses the treatment of urinary incontinence, gastroesophageal reflux disease and the amelioration of skin wrinkles using biocompatible hydrophilic cationic microparticles and a cell adhesion promoter.Type: GrantFiled: December 28, 2001Date of Patent: June 13, 2006Assignee: BioSphere Medical, Inc.Inventors: Jean Marie Vogel, Richard Thomas, Egisto Boschetti
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Publication number: 20060067883Abstract: One aspect of the present invention relates to a microsphere, comprising a hydrophilic polymer comprising a plurality of pendant anionic groups; a transition-metal, lanthanide or group 13-14 metal oxide, polyoxometalate or metal hydroxide or combination thereof; and a first radioisotope that emits a therapeutic ?-particle. In certain embodiments, the microsphere further comprsies a second radioisotope that emits a diagnostic ?-ray; wherein the atomic number of the first radioisotope is not the same as the atomic number of the second radioisotope. In certain embodiments, the microsphere is composed of polymer impregnated with zirconia bound to 32p as the source of the therapeutic ?-emissions and 67Ga as the source of the diagnostic ?-emissions.Type: ApplicationFiled: July 19, 2005Publication date: March 30, 2006Applicant: Biosphere Medical, Inc.Inventors: James Krom, Alexander Schwarz
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Patent number: 6884905Abstract: One aspect of the present invention relates to base-labile, carbamate-containing crosslinkers. A second aspect of the present invention relates to degradable crosslinked polymers and hydrogels comprising a base-labile, carbamate-containing crosslinker. The present invention also relates to methods of preparing base-labile, carbamate-containing crosslinkers. Another aspect of the present invention relates to methods of preparing cross-linked polymers and hydrogels comprising a base-labile, carbamate-containing crosslinker.Type: GrantFiled: February 25, 2003Date of Patent: April 26, 2005Assignee: Biosphere MedicalInventors: Hongmin Zhang, Alexander Schwarz
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Patent number: 6790456Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further relates to methods of dermal augmentation, particularly for the treatment of skin contour deficiencies, using the injectable compositions.Type: GrantFiled: August 19, 2002Date of Patent: September 14, 2004Assignee: Biosphere Medical, Inc.Inventors: Jean-Marie Vogel, Egisto Boschetti
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Publication number: 20040096514Abstract: The present invention relates to elastic, hydrophilic and substantially spherical microspheres useful for dermal augmentation and tissue bulking. The invention provides injectable compositions comprising the microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further provides methods of dermal augmentation and tissue bulking, particularly for the treatment of skin contour deficiencies, Gastro-esophageal reflux disease, urinary incontinence, and urinary reflux disease, using the injectable compositions.Type: ApplicationFiled: November 12, 2003Publication date: May 20, 2004Applicant: BioSphere Medical, Inc.Inventors: Jean-Marie Vogel, Richard Thomas, Egisto Boschetti
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Publication number: 20040091425Abstract: The present invention relates to microspheres useful for embolization which comprises polyvinylalcohol. The present invention also relates to an injectable suspension suitable for embolization which comprises the polyvinylalcohol microspheres and a suitable liquid carrier. The present invention further relates to a method for prophylactic or therapeutic embolization which comprises administering to a mammal an injectable suspension containing the polyvinylalcohol microspheres and a suitable liquid carrier. Finally, the present invention relates to a process for producing the polyvinylalcohol microspheres.Type: ApplicationFiled: October 27, 2003Publication date: May 13, 2004Applicant: Biosphere Medical, S.A.Inventor: Egisto Boschetti
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Patent number: 6713646Abstract: One aspect of the present invention relates to base-labile crosslinkers. A second aspect of the present invention relates to degradable crosslinked polymers and hydrogels comprising a base-labile crosslinker. The present invention also relates to a method of influencing the degradation rate of a crosslinked polymer or hydrogel, comprising the step of incorporating uncharged acrylamides into the crosslinked polymer or hydrogel.Type: GrantFiled: June 27, 2002Date of Patent: March 30, 2004Assignee: Biosphere MedicalInventors: Hongmin Zhang, Alexander Schwarz
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Patent number: 6680046Abstract: The present invention relates to microspheres useful for embolization which comprises polyvinylalcohol. The present invention also relates to an injectable suspension suitable for embolization which comprises the polyvinylalcohol microspheres and a suitable liquid carrier. The present invention further relates to a method for prophylactic or therapeutic embolization which comprises administering to a mammal an injectable suspension containing the polyvinylalcohol microspheres and a suitable liquid carrier. Finally, the present, invention relates to a process for producing the polyvinylalcbhol microspheres.Type: GrantFiled: October 15, 1999Date of Patent: January 20, 2004Assignee: Biosphere Medical, S.A.Inventor: Egisto Boschetti
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Patent number: 6660301Abstract: The present invention relates to elastic, hydrophilic and substantially spherical microspheres useful for dermal augmentation and tissue bulking. The invention provides injectable compositions comprising the microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further provides methods of dermal augmentation and tissue bulking, particularly for the treatment of skin contour deficiencies, Gastro-esophageal reflux disease, urinary incontinence, and urinary reflux disease, using the injectable compositions.Type: GrantFiled: March 20, 2000Date of Patent: December 9, 2003Assignee: Biosphere Medical, Inc.Inventors: Jean-Marie Vogel, Richard Thomas, Egisto Boschetti
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Publication number: 20020197326Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further relates to methods of dermal augmentation, particularly for the treatment of skin contour deficiencies, using the injectable compositions.Type: ApplicationFiled: August 19, 2002Publication date: December 26, 2002Applicant: BioSphere Medical, Inc.Inventors: Jean-Marie Vogel, Egisto Boschetti
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Patent number: 6436424Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further relates to methods of dermal augmentation, particularly for the treatment of skin contour deficiencies, using the injectable compositions.Type: GrantFiled: March 20, 2000Date of Patent: August 20, 2002Assignee: Biosphere Medical, Inc.Inventors: Jean-Marie Vogel, Egisto Boschetti