Patents Assigned to Biostage, Inc.
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Patent number: 11485943Abstract: Aspects of the disclosure relate to rotating bioreactors and articles and methods that are useful for adapting a rotating bioreactor for use with tissues or scaffolds of different sizes. In some embodiments, bioreactors comprising a reservoir and an arbor assembly are provided herein, in which the arbor assembly comprises a rotatable support to which a tissue or tissue scaffold can be attached.Type: GrantFiled: October 25, 2019Date of Patent: November 1, 2022Assignee: Biostage, Inc.Inventor: Herbert Hedberg
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Patent number: 11464887Abstract: Aspects of the disclosure relate methods and a synthetic cell delivery device for treating trauma present relative to the inner surface of a hollow organ such as an esophagus.Type: GrantFiled: October 4, 2019Date of Patent: October 11, 2022Assignee: Biostage, Inc.Inventors: Linghui Meng, Shunfu Hu, William Fodor
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Patent number: 11284987Abstract: Aspects of the invention relate to a combination of techniques and/or materials that can be used to form a synthetic scaffold for solid and/or hollow organs or tissue. In some embodiments, methods are provided that involve assembling a synthetic scaffold using a first material for a first structural component and a second material for a second structural component, in which the first or second structural component is a perfusion pathway. In some embodiments, materials (e.g., synthetic materials) for the scaffold are printed, molded, cast, polymerized, or electrospun. In some embodiments, a scaffold may mimic a natural scaffold or several features of a natural scaffold.Type: GrantFiled: January 9, 2014Date of Patent: March 29, 2022Assignee: Biostage, Inc.Inventor: Ron Sostek
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Patent number: 11266763Abstract: Aspects of the disclosure relate methods and synthetic scaffolds for regenerating hallow organs present in the respiratory system such as bronchus tissue.Type: GrantFiled: October 4, 2019Date of Patent: March 8, 2022Assignee: Biostage, Inc.Inventors: William Fodor, Linghui Meng, Sherif Soliman, Shunfu Hu
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Patent number: 11234805Abstract: Aspects of the disclosure relate methods and synthetic scaffolds for regenerating gastrointestinal tissue (e.g., esophageal tissue).Type: GrantFiled: April 22, 2019Date of Patent: February 1, 2022Assignee: Biostage, Inc.Inventors: Saverio La Francesca, Sherif Soliman, Matthew Marsh, Shunfu Hu, Linghui Meng
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Publication number: 20200056134Abstract: Aspects of the disclosure relate to rotating bioreactors and articles and methods that are useful for adapting a rotating bioreactor for use with tissues or scaffolds of different sizes. In some embodiments, bioreactors comprising a reservoir and an arbor assembly are provided herein, in which the arbor assembly comprises a rotatable support to which a tissue or tissue scaffold can be attached.Type: ApplicationFiled: October 25, 2019Publication date: February 20, 2020Applicant: Biostage, Inc.Inventor: Herbert Hedberg
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Patent number: 10544387Abstract: Aspects of the disclosure relate to bioreactors for maintaining biological objects (e.g., organ or engineered tissues) under culture conditions. In some embodiments, bioreactors and cover assemblies are provided that comprise a support base for supporting a biological object. In some embodiments, bioreactors and cover assemblies are provided that comprise a movable support base configured such that a user can manipulate its position and thus the relative position of the biological object.Type: GrantFiled: March 27, 2014Date of Patent: January 28, 2020Assignee: Biostage, Inc.Inventor: Herbert Hedberg
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Patent number: 10457905Abstract: Aspects of the disclosure relate to rotating bioreactors and articles and methods that are useful for adapting a rotating bioreactor for use with tissues or scaffolds of different sizes. In some embodiments, bioreactors comprising a reservoir and an arbor assembly are provided herein, in which the arbor assembly comprises a rotatable support to which a tissue or tissue scaffold can be attached.Type: GrantFiled: March 15, 2014Date of Patent: October 29, 2019Assignee: Biostage, Inc.Inventor: Herbert Hedberg
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Patent number: 10449026Abstract: Aspects of the disclosure relate to synthetic tissue or organ scaffolds and methods and compositions for promoting or maintaining their structural integrity. Aspects of the disclosure are useful to prevent scaffold damage (e.g., delamination) during or after implantation into a host. Aspects of the disclosure are useful to stabilize tissue or organ scaffolds that include electrospun fibers.Type: GrantFiled: June 26, 2013Date of Patent: October 22, 2019Assignee: Biostage, Inc.Inventors: Ron Sostek, David Green, Linghui Meng, Sherif Soliman, Joseph Consiglio
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Patent number: 10265153Abstract: Aspects of the disclosure relate methods and synthetic scaffolds for regenerating gastrointestinal tissue (e.g., esophageal tissue).Type: GrantFiled: November 14, 2016Date of Patent: April 23, 2019Assignee: Biostage, Inc.Inventors: Saverio La Francesca, Sherif Soliman, Matthew Marsh
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Patent number: 9918463Abstract: The invention relates to a bioreactor for charging the outside and the interior of a hollow element (1) or hollow element framework with a liquid, having a housing (2) accommodating the liquid, forming a liquid surface, and a rotation device (3) arranged within the housing (2) and receiving the hollow element (1), which rotation device (3) is for rotating the hollow element (1) about the longitudinal axis (4) thereof in the region of the liquid surface. In known bioreactors of this type, the interior of the hollow element must be flushed with a special device, and so here also a liquid exchange takes place.Type: GrantFiled: May 23, 2012Date of Patent: March 20, 2018Assignee: BIOSTAGE, INC.Inventors: Roger Zink, Hermann Rees, Ottmar Heiny
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Patent number: 9877822Abstract: According to some aspects, supports are provided for producing artificial tissue scaffolds.Type: GrantFiled: April 24, 2013Date of Patent: January 30, 2018Assignee: Biostage, Inc.Inventor: Thomas Grosse