Patents Assigned to Biostatus Limited
  • Patent number: 10385009
    Abstract: An anthraquinone compound of formula I (such as the compounds of formulae II to X) and processes for making the same are provided. Pharmaceutical compositions for use in the treatment of cancer, optionally in combination with an agent capable of reducing the level of oxygenation of a tumor, are also provided. Additionally, an option for combination with chemotherapeutic and radiotherapeutic modalities to enhance overall tumor cell kill is provided. Methods for the detection of cellular hypoxia, both in vivo and in vitro, are additionally provided.
    Type: Grant
    Filed: August 7, 2013
    Date of Patent: August 20, 2019
    Assignee: BIOSTATUS LIMITED
    Inventors: Stefan Ogrodzinski, Paul Smith, Stephanie McKeown, Laurence Patterson, Rachel Jane Errington
  • Patent number: 9759715
    Abstract: The present invention provides the use of a composition comprising a block polymer as a support matrix in the manipulation, processing or analysis of particles, such as cells and fluorescent beads. In a preferred embodiment, the composition exhibits gel-sol thermoreversibility, micelle formation under gelling conditions, optically compatible, controllable surfactant properties, molecular sieving properties and biocompatibility. Further aspects of the invention provide (a) a support matrix composition comprising a block polymer, fluorescent beads and/or a dye for use in the manipulation, processing or analysis of particles, (b) a multichamber plate coated in a support matrix composition and (c) kits for producing the same.
    Type: Grant
    Filed: March 29, 2010
    Date of Patent: September 12, 2017
    Assignee: Biostatus Limited
    Inventors: Paul Smith, Laurence Patterson, Rachel Jane Errington
  • Publication number: 20150307441
    Abstract: An anthraquinone compound of formula I (such as the compounds of formulae II to X) and processes for making the same are provided. Pharmaceutical compositions for use in the treatment of cancer, optionally in combination with an agent capable of reducing the level of oxygenation of a tumour, are also provided. Additionally, an option for combination with chemotherapeutic and radiotherapeutic modalities to enhance overall tumour cell kill is provided. Methods for the detection of cellular hypoxia, both in vivo and in vitro, are additionally provided.
    Type: Application
    Filed: August 7, 2013
    Publication date: October 29, 2015
    Applicant: Biostatus Limited
    Inventors: Stefan Ogrodzinski, Paul Smith, Stephanie McKeown, Laurence Patterson, Rachel Jane Errington
  • Patent number: 9051467
    Abstract: According to the invention there is provided a compound of Formula (I) in which: A is a C2-8 alkylene group; R1, R2, R3, and R4 are independently selected from hydrogen, C1-4 alkyl, C2-4 dihydroxyalkyl in which the carbon atom attached to the nitrogen atom does not carry a hydroxyl group and no carbon atom is substituted by two hydroxyl groups, or R2 and R3 together form a C2-6 alkylene group which with the nitrogen atom to which R2 and R3 are attached forms a heterocyclic ring; X1, X2 and X3 are independently selected from hydrogen, hydroxyl, NR1-A-NR2R3R4+(Zm?)1/m, halogeno amino, C1-4 alkoxy or C2-8 alkanoyloxy; and (Zm?)1/m is an anion of charge m; or a derivative in which the group NR1 is quaternarised.
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: June 9, 2015
    Assignee: BIOSTATUS LIMITED
    Inventors: Paul James Smith, Rachel J. Errington, Laurence Hylton Patterson
  • Publication number: 20130101994
    Abstract: According to the invention there is provided a compound of Formula (I) in which: A is a C2-8 alkylene group; R1, R2, R3, and R4 are independently selected from hydrogen, C1-4 alkyl, C2-4 dihydroxyalkyl in which the carbon atom attached to the nitrogen atom does not carry a hydroxyl group and no carbon atom is substituted by two hydroxyl groups, or R2 and R3 together form a C2-6 alkylene group which with the nitrogen atom to which R2 and R3 are attached forms a heterocyclic ring; X1, X2 and X3 are independently selected from hydrogen, hydroxyl, NR1-A-NR2R3R4+(Zm?)1/m, halogeno amino, C1-4 alkoxy or C2-8 alkanoyloxy; and (Zm?)1/m is an anion of charge m; or a derivative in which the group NR1 is quaternarised.
    Type: Application
    Filed: April 8, 2011
    Publication date: April 25, 2013
    Applicant: BIOSTATUS LIMITED
    Inventors: Paul James Smith, Rachel J. Errington, Laurence Hylton Patterson
  • Patent number: 7723085
    Abstract: The present invention provides the use of a composition comprising a block polymer as a support matrix in the manipulation, processing or analysis of particles, such as cells and fluorescent beads. In a preferred embodiment, the composition exhibits gel-sol thermoreversibility, micelle formation under gelling conditions, optically compatible, controllable surfactant properties, molecular sieving properties and biocompatibility. Further aspects of the invention provide (a) a support matrix composition comprising a block polymer, fluorescent beads and/or a dye for use in the manipulation, processing or analysis of particles, (b) a multichamber plate coated in a support matrix composition and (c) kits for producing the same.
    Type: Grant
    Filed: July 1, 2005
    Date of Patent: May 25, 2010
    Assignee: Biostatus Limited
    Inventors: Paul Smith, Laurence Patterson, Rachel Jane Errington
  • Patent number: 7605280
    Abstract: There is disclosed a compound of formula (I) wherein each of X1 and X2 are independently NH-A-NR1R2, and wherein A is A C2-8 alkylene and R1 and R2 are independently selected from hydrogen, C1-4 alkyl, C2-4 hydroxy-alkyl and C2-4 aminoalkyl, or R1 and R2 together form a C2-6 alkylene group which with the nitrogen atom to which R1 and R2 are attached forms a heterocyclic ring, or an N-oxide derivative thereof, and wherein the compound (I) or its N-oxide derivative is optionally in the form of an acid salt derived from an organic or inorganic acid. Also disclosed is a method of its production and its uses, including its use in analyzing a cell or biological material and detecting the emitted fluorescence signal.
    Type: Grant
    Filed: March 6, 2006
    Date of Patent: October 20, 2009
    Assignee: Biostatus Limited
    Inventors: Paul James Smith, Laurence Hylton Patterson
  • Publication number: 20080182287
    Abstract: The present invention provides the use of a composition comprising a block polymer as a support matrix in the manipulation, processing or analysis of particles, such as cells and fluorescent beads. In a preferred embodiment, the composition exhibits gel-sol thermoreversibility, micelle formation under gelling conditions, optically compatible, controllable surfactant properties, molecular sieving properties and biocompatibility. Further aspects of the invention provide (a) a support matrix composition comprising a block polymer, fluorescent beads and/or a dye for use in the manipulation, processing or analysis of particles, (b) a multichamber plate coated in a support matrix composition and (c) kits for producing the same.
    Type: Application
    Filed: July 1, 2005
    Publication date: July 31, 2008
    Applicant: BIOSTATUS LIMITED
    Inventors: Paul Smith, Laurence Patterson, Rachel Jane Errington
  • Publication number: 20060148777
    Abstract: There is disclosed a compound of formula (I) wherein each of X1 and X2 are independently NH-A-NR1R2, and wherein A is A C2-8 alkylene and R1 and R2 are independently selected from hydrogen, C1-4 alkyl, C2-4 hydroxy-alkyl and C2-4 aminoalkyl, or R1 and R2 together form a C2-6 alkylene group which with the nitrogen atom to which R1 and R2 are attached forms a heterocyclic ring, or an N-oxide derivative thereof, and wherein the compound (I) or its N-oxide derivative is optionally in the form of an acid salt derived from an organic or inorganic acid. Also disclosed is a method of its production and its uses, including its use in analyzing a cell or biological material and detecting the emitted fluorescence signal.
    Type: Application
    Filed: March 6, 2006
    Publication date: July 6, 2006
    Applicant: BIOSTATUS LIMITED
    Inventors: Paul Smith, Laurence Patterson
  • Patent number: 7060427
    Abstract: There is disclosed a compound of formula (I) wherein each of X1 and X2 are independently NH—A—NR1R2, and wherein A is A C2-8 alkylene and R1 and R2 are independently selected from hydrogen, C1-4 alkyl, C2-4 hydroxy-alkyl and C2-4 aminoalkyl, or R1 and R2 together form a C2-6 alkylene group which with the nitrogen atom to which R1 and R2 are attached forms a heterocyclic ring, or an N-oxide derivative thereof, and wherein the compound (I) or its N-oxide derivative is optionally in the form of an acid salt derived from an organic or inorganic acid. Also disclosed is a method of its production and its uses, including its use in analyzing a cell or biological material and detecting the emitted fluorescence signal.
    Type: Grant
    Filed: August 12, 2002
    Date of Patent: June 13, 2006
    Assignee: Biostatus Limited
    Inventors: Paul James Smith, Laurence Hylton Patterson
  • Publication number: 20030008316
    Abstract: There is disclosed a compound of formula (I) wherein each of X1 and X2 are independently NH—A—NR1R2, and wherein A is A C2-8 alkylene and R1 and R2 are independently selected from hydrogen, C1-4 alkyl, C2-4 hydroxy-alkyl and C2-4 aminoalkyl, or R1 and R2 together form a C2-6 alkylene group which with the nitrogen atom to which R1 and R2 are attached forms a heterocyclic ring, or an N-oxide derivative thereof, and wherein the compound (I) or its N-oxide derivative is optionally in the form of an acid salt derived from an organic or inorganic acid. Also disclosed is a method of its production and its uses, including its use in analyzing a cell or biological material and detecting the emitted fluorescence signal.
    Type: Application
    Filed: August 12, 2002
    Publication date: January 9, 2003
    Applicant: BIOSTATUS LIMITED
    Inventors: Paul James Smith, Laurence Hylton Patterson
  • Patent number: 6468753
    Abstract: There is disclosed a compound of formula (I) wherein each of X1 and X2 are independently NH—A—NR1R2, and wherein A is A C2-8 alkylene group and R1 and R2 are independently selected from hydrogen, C1-4 alkyl, C2-4 hydroxy-alkyl and C2-4 aminoalkyl, or R1 and R2 together form a C2-6 alkylene group which with the nitrogen atom to which R1 and R2 are attached forms a heterocyclic ring, or an N-oxide derivative thereof, and wherein the compound (I) or its N-oxide derivative is optionally in the form of an acid salt derived from an organic or inorganic acid. Also disclosed is a method of its production and its uses, including its use in analyzing a cell or biological material and detecting the emitted fluorescence signal.
    Type: Grant
    Filed: February 20, 2001
    Date of Patent: October 22, 2002
    Assignee: Biostatus Limited
    Inventors: Paul James Smith, Laurence Hylton Patterson