Patents Assigned to BIOSTEED GENE EXPRESSION TECH. CO., LTD.
  • Double-stranded polyethylene glycol modified growth hormone, preparation method and application thereof
    Patent number: 9840546
    Abstract: The growth hormone with high biological activity modified by the double-stranded polyethylene glycol at a single site and the preparation method thereof are provided. The PEGylated growth hormone has a higher biological activity and a longer half-life than the unmodified growth hormone. The composition comprising the PEGylated growth hormone is useful in the treatment of the growth or development disorder such as growth hormone deficiency, Turner syndrome etc.
    Type: Grant
    Filed: April 3, 2008
    Date of Patent: December 12, 2017
    Assignee: Biosteed Gene Expression Tech. Co., Ltd.
    Inventors: Weidong Zhou, Xiaojin Liao, Li Sun, Linzhong Zhang, Qingsong Lu, Shiye Shen, Lishan Yang, Defang Zhang, Huihuang Lin, Ping Zhang
  • Interferon alpha-2B modified by polyethylene glycol and methods of preparation thereof
    Patent number: 8597635
    Abstract: The present invention relates to interferon-?2b modified with Y-shaped branched polyethylene glycol (PEG) at a single Lys residue and the preparation thereof. The peglated IFN-?2b can be used for the preparation of a medicament for treating a disease, e.g. viral infections such as Hepatitis C.
    Type: Grant
    Filed: September 4, 2007
    Date of Patent: December 3, 2013
    Assignee: Biosteed Gene Expression Tech. Co., Ltd.
    Inventors: Weidong Zhou, Qingjiang Xiao, Li Sun, Tiebing Wang, Fenghong Yin, Shihong Luo, Lu Zhuang, Min Liu, Tianle Xu, Yong Zhang
  • Interferon alpha-2a modified by polyethylene glycol and methods of preparation thereof
    Patent number: 8597634
    Abstract: The present invention relates to interferon (IFN)-?2a modified at a specific Lys residue with Y-shaped branched polyethylene glycol (PEG) derivative and the preparation thereof, as well as the use of the prepared IFN-?2a modified by PEG at a single amino acid residue in medicines.
    Type: Grant
    Filed: September 4, 2007
    Date of Patent: December 3, 2013
    Assignee: Biosteed Gene Expression Tech. Co., Ltd.
    Inventors: Weidong Zhou, Qingjiang Xiao, Li Sun, Tiebing Wang, Bin Liu, Song Lin, Min Liu, Fenghong Yin, Lu Zhuang, Lifang Lei
  • Y-shaped polyethylene glycol modified G-CSF, the preparation and use thereof
    Patent number: 8530417
    Abstract: The present invention relates to granulocyte colony stimulating factor (G-CSF) modified with Y-shaped branched polyethylene glycol (YPEG-G-CSF) at a specific lysine (Lys 17) and the preparation thereof, as well as the pharmaceutical composition comprising YPEG-G-CSF and use thereof.
    Type: Grant
    Filed: December 29, 2007
    Date of Patent: September 10, 2013
    Assignee: Biosteed Gene Expression Tech Co. Ltd.
    Inventors: Shiyuan Wang, Jianhua Zheng, Li Sun, Huili Cai, Meihua Yang, Yan He, Ping Chen, Hongyuan Deng, Liping Zhong, Shuying Huang
  • Y-SHAPED POLYETHYLENE GLYCOL MODIFIED G-CSF, THE PREPARATION AND USE THEREOF
    Publication number: 20110280826
    Abstract: The present invention relates to granulocyte colony stimulating factor (G-CSF) modified with Y-shaped branched polyethylene glycol (YPEG-G-CSF) at a specific lysine (Lys 17) and the preparation thereof, as well as the pharmaceutical composition comprising YPEG-G-CSF and use thereof.
    Type: Application
    Filed: December 29, 2007
    Publication date: November 17, 2011
    Applicant: Biosteed Gene Expression Tech Co. ltd
    Inventors: Shiyuan Wang, Jianhua Zheng, Li Sun, Huili Cai, Meihua Yang, Yan He, Ping Chen, Hongyuan Deng, Liping Zhong, Shuying Huang
  • INTERFERON ALPHA2A MODIFIED BY POLYETHYLENE GLYCOL, THE PREPARATION AND USE THEREOF
    Publication number: 20100239532
    Abstract: The present invention relates to interferon (IFN)-?2a modified at a specific Lys residue with Y-shaped branched polyethylene glycol (PEG) derivative and the preparation thereof, as well as the use of the prepared IFN-?2a modified by PEG at a single amino acid residue in medicines.
    Type: Application
    Filed: September 4, 2007
    Publication date: September 23, 2010
    Applicant: BIOSTEED GENE EXPRESSION TECH. CO., LTD.
    Inventors: Weidong Zhou, Qingjing Xiao, Li Sun, Tlebing Wang, Bin Liu, Song Lin, Min Liu, Fenghong Yin, Lu Zhuang, Lifang Lei