Patents Assigned to Biostratum AB
  • Inhibition of the beta3 subunit of L-type Ca2+ channels
    Publication number: 20030180712
    Abstract: The present invention provides reagents and methods for identifying inhibitors of the L-type Ca2+ channel &bgr;3 protein, which has been demonstrated to be involved in calcium signaling, insulin secretion, and glucose homeostasis. The invention also provides therapeutics and methods for treating a subject with one or more of diabetes, insulin resistance, impaired insulin secretion, and impaired glucose homeostasis, involving the use of inhibitors of an L-type Ca2+ channel &bgr;3 subunit to provide a benefit to the subject.
    Type: Application
    Filed: March 19, 2003
    Publication date: September 25, 2003
    Applicant: BioStratum AB
    Inventors: Per-Olof Berggren, Veit Flockerzi
  • Laminin chains: diagnostic and therapeutic use
    Publication number: 20030100529
    Abstract: The instant invention provides for the identification, diagnosis, monitoring, and treatment of invasive cells using the laminin 5 gamma-2 chain protein or nucleic acid sequence, or antibodies thereto.
    Type: Application
    Filed: August 26, 2002
    Publication date: May 29, 2003
    Applicant: BioStratum AB
    Inventors: Karl Tryggvason, Pekka Kallunki, Charles Pyke
  • Nephrin gene and protein
    Publication number: 20020004589
    Abstract: The present invention provides for compositions and methods for detecting susceptibility for basement membrane disease, in particular Congenital nephrotic syndromes of the Finnish type. The present invention provides for nucleic acids and protein for use in methods and compositions for the diagnosis of disease and identification of small molecule therapeutics for treatment of such disease, in particular of proteinuria associated with kidney disease.
    Type: Application
    Filed: January 12, 2001
    Publication date: January 10, 2002
    Applicant: Biostratum AB
    Inventors: Karl Tryggvason, Marjo Kestila, Ulla Lenkkeri, Minna Mannikko