Abstract: The present invention provides methods and devices for the delivery of pharmaceuticals to target tissues in situ, in vivo, ex vivo, or in vitro. In particular, the methods and devices relate to contacting a target tissue with a pharmaceutical in a re-circulating, oxygenated perfusate solution to provide for effective delivery of the pharmaceutical to the target tissue.
Type:
Grant
Filed:
June 30, 2000
Date of Patent:
October 28, 2003
Assignee:
Biostratum Incorporation
Inventors:
Karl Tryggvason, Olavi Lukkarinen, Pirkko Heikkilä, Teija Parpala