Abstract: The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite material formed as a discrete textile fabric from a prepared liquid admixture of (i) a non-biodegradable durable synthetic polymer; (ii) a biologically active agent; and (iii) a liquid organic carrier. These biologically-active agents are chemical compounds which retain their recognized biological activity both before and after becoming non-permanently bound to the formed textile material; and will become subsequently released in-situ as discrete freely mobile agents front the fabric upon uptake of water from the ambient environment.
Type:
Grant
Filed:
February 18, 2016
Date of Patent:
October 15, 2019
Assignees:
BIOSURFACES, INC., RHODE ISLAND BOARD OF EDUCATION, CLEMSON UNIVERSITY
Inventors:
Matthew D. Phaneuf, Philip J. Brown, Martin J. Bide
Abstract: The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite material formed as a discrete textile fabric from a prepared liquid admixture of (i) a non-biodegradable durable synthetic polymer; (ii) a biologically active agent; and (iii) a liquid organic carrier. These biologically-active agents are chemical compounds which retain their recognized biological activity both before and after becoming non-permanently bound to the formed textile material; and will become subsequently released in-situ as discrete freely mobile agents from the fabric upon uptake of water from the ambient environment.
Type:
Grant
Filed:
June 2, 2014
Date of Patent:
June 25, 2019
Assignees:
BIOSURFACES, INC., RHODE ISLAND BOARD OF EDUCATION, CLEMSON UNIVERSITY
Inventors:
Matthew D. Phaneuf, Philip J. Brown, Martin J. Bide
Abstract: The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite material formed as a discrete textile fabric from a prepared liquid admixture of (i) a non-biodegradable durable synthetic polymer; (ii) a biologically active agent; and (iii) a liquid organic carrier. These biologically-active agents are chemical compounds which retain their recognized biological activity both before and after becoming non-permanently bound to the formed textile material; and will become subsequently released in-situ as discrete freely mobile agents front the fabric upon uptake of water from the ambient environment.
Type:
Application
Filed:
February 18, 2016
Publication date:
June 9, 2016
Applicants:
BioSurfaces, Inc., Clemson University, Rhode Island Board of Education
Inventors:
Matthew D. Phaneuf, Philip J. Brown, Martin J. Bide
Abstract: The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite material formed as a discrete textile fabric from a prepared liquid admixture of (i) a non-biodegradable durable synthetic polymer; (ii) a biologically active agent; and (iii) a liquid organic carrier. These biologically-active agents are chemical compounds which retain their recognized biological activity both before and after becoming non-permanently bound to the formed textile material; and will become subsequently released in-situ as discrete freely mobile agents from the fabric upon uptake of water from the ambient environment.
Type:
Application
Filed:
June 2, 2014
Publication date:
September 18, 2014
Applicants:
BioSurfaces, Inc., Clemson University, Rhode Island Board of Education
Inventors:
Matthew D. Phaneuf, Philip J. Brown, Martin J. Bide