Abstract: The present disclosure described heterocyclic compounds of Formula I or, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivative thereof and pharmaceutical compositions containing them as the active ingredient. The present disclosure also describes the synthesis and characterization of aforementioned compounds to exhibit high anticancer activity. The compounds of the present disclosure are useful as medicaments and their use in the manufacture of medicaments for treatment, prevention or suppression of diseases, and conditions mediated by one or more BET family of bromodomains.

Abstract: The present disclosure describes heterocyclic compounds of Formula I or, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivatives thereof and pharmaceutical compositions containing them as the active ingredient. The present disclosure also describes the synthesis and characterization of aforementioned compounds to exhibit high anticancer activity. The compounds of the present disclosure are useful as medicaments and their use in the manufacture of medicaments for treatment, prevention, or suppression of diseases, an conditions mediated b one or more BET family of bromodomains.

Abstract: The present disclosure describes heterocyclic compounds of Formula I or, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivatives thereof and pharmaceutical compositions containing them as the active ingredient. The present disclosure also describes the synthesis and characterization of aforementioned compounds to exhibit high anticancer activity. The compounds of the present disclosure are useful as medicaments and their use in the manufacture of medicaments for treatment, prevention, or suppression of diseases, an conditions mediated b one or more BET family of bromodomains.

Abstract: The present disclosure described heterocyclic compounds of Formula I or, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivative thereof and pharmaceutical compositions containing them as the active ingredient. The present disclosure also describes the synthesis and characterization of aforementioned compounds to exhibit high anticancer activity. The compounds of the present disclosure are useful as medicaments and their use in the manufacture of medicaments for treatment, prevention or suppression of diseases, and conditions mediated by one or more BET family of bromodomains.

Abstract: The present disclosure describes heterocyclic compounds of Formula I or, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivatives thereof and pharmaceutical compositions containing them as the active ingredient. The present disclosure also describes the synthesis and characterization of aforementioned compounds to exhibit high anticancer activity. The compounds of the present disclosure are useful as medicaments and their use in the manufacture of medicaments for treatment, prevention, or suppression of diseases, and conditions mediated by one or more BET family of bromodomains.

Abstract: The present disclosure described heterocyclic compounds of Formula I or, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivative thereof and pharmaceutical compositions containing them as the active ingredient. The present disclosure also describes the synthesis and characterization of aforementioned compounds to exhibit high anticancer activity. The compounds of the present disclosure are useful as medicaments and their use in the manufacture of medicaments for treatment, prevention or suppression of diseases, and conditions mediated by one or more BET family of bromodomains.

Abstract: The present disclosure relates to pyrimidine compounds of formula (I), their stereoisomers, tautomers, pharmaceutically acceptable salts, polymorphs, solvates, and hydrates thereof. The present disclosure also relates to process of preparation of these pyrimidine compounds, and to pharmaceutical compositions containing them. The compounds of the present disclosure are useful in the treatment, prevention or suppression of diseases and disorders mediated by epidermal growth factor receptor (EGFR) family kinases.

Abstract: The present disclosure described heterocyclic compounds of Formula I or, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivative thereof and pharmaceutical compositions containing them as the active ingredient. The present disclosure also describes the synthesis and characterization of aforementioned compounds to exhibit high anticancer activity. The compounds of the present disclosure are useful as medicaments and their use in the manufacture of medicaments for treatment, prevention or suppression of diseases, and conditions mediated by one or more BET family of bromodomains.

Abstract: The present disclosure describes heterocyclic compounds of Formula I or, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivatives thereof and pharmaceutical compositions containing them as the active ingredient. The present disclosure also describes the synthesis and characterization of aforementioned compounds to exhibit high anticancer activity. The compounds of the present disclosure are useful as medicaments and their use in the manufacture of medicaments for treatment, prevention, or suppression of diseases, and conditions mediated by one or more BET family of bromodomains.

Abstract: A dental alloy contains palladium (Pd) and indium (In) for CAD/CAM machining. The dental alloy can further include one component selected from the group consisting of gold (Au), silver (Ag), nickel (Ni), cobalt (Co), and platinum (Pt). The dental alloy has a yield strength of 250 MPa to 450 MPa, breaking elongation of 2% to 8%, metal-ceramic adhesion of 20 MPa to 70 MPa, coefficient of linear thermal expansion of 14.0×10?6/K to 17.0×10?6/K, or density of 8 g/cm3 to 15 g/cm3.

Abstract: The present invention relates to a dental alloy for machining by a CAD/CAM system. In particular, the dental alloy for machining by a CAD/CAM system features a minimum usage of expensive gold and platinum by comprising gold (Au) in an amount of between 0.1% and 5.0% by weight and platinum (Pt) in an amount of between 0% and 5.0% by weight, in addition to palladium (Pd) in an amount of between 30% and 50% by weight, indium (In) in an amount of between 25% and 50% by weight, silver (Ag) in an amount of between 10% and 40% by weight and iridium (Ir) in an amount of between 0.1% and 0.3% by weight. Accordingly, compared with a conventional dental casting alloy composed of gold in an amount of between 40% and 99% the dental alloy for machining by a CAD/CAM system of the invention can be provided at a lower manufacturing cost, while offering processability equivalent to that of zirconia that can be machined by a conventional CAD/CAM system.

Abstract: A composting system including a vertically-orientated vessel with mechanisms attached to a vertically oriented central mounted rotating shaft, including rotatable size reduction blade(s), agitation mechanism(s), and discharge blade/mechanism(s). The composting system includes internal size reduction mechanism for reducing the size of material introduced to the vessel. The composting system includes a loading hatch, a discharge hatch, and a source of air to maintain aerobic conditions within the vessel. In use, material introduced moves from the upper region of the vessel gravitationally and via agitation through a zone of size reduction to the lower region of the vessel. Process conditions within the vessel are controlled by an operator and via electronic control mechanism, which can monitor operating conditions such as temperature and loading rate (for example), to manage air injection, mechanical agitation and size reduction such that composting proceeds efficiently and at an optimal rate.

Abstract: The present invention provides a novel homology three-dimensional structure of Glycogen Synthase Kinase 3-Alpha (GSK3-Alpha) or a variant thereof for screening, designing and/or synthesizing a modulator that modulates the activity of GSK3-Alpha and method of generating said three dimensional structure thereof. The three-dimensional structure of GSK3-Alpha is defined by at least a portion of structural co-ordinates of Table 1. Further, the present invention provides a computer assisted system for generating said three-dimensional structure of GSK3-Alpha or a variant thereof. Further, the present invention relates to a method of screening, designing and/or synthesizing a modulator for modulating the activity of GSK3-? or a variant thereof.

Abstract: The present invention relates to a compound of formula (I) or its stereoisomers, tautomers, solvates, hydrates, prodrugs, pharmaceutically acceptable salts or mixtures thereof, or pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof. The present invention also provides a method for the prophylaxis or treatment of a medical condition associated with protein kinase, by administering a pharmaceutically effective amount of the compound of formula (I) or salts thereof.

Abstract: An apparatus and method for automatic balancing and inertial damping of vibrations in a rotor are disclosed. According to one embodiment, a rotor drive shaft is adapted to mount a rotor and rotate the rotor. A lower drive shaft connects to a source of rotation. A flexible coupling attaches the rotor drive shaft to the lower drive shaft and transfers a rotational force applied by the source of rotation to the rotor while permitting relative lateral motion between the rotor drive shaft and the lower drive shaft. An inertial coupling is coupled to the rotor drive shaft and provides inertial resistance to the relative lateral motion. A clamping collar is coupled to the inertial coupling to couple the inertial coupling to a chassis and permit the relative lateral motion between the rotor drive shaft and the lower drive shaft.

Abstract: A composition for treating Xanthomonas spp. infections in agriculture crops wherein the treatment composition is an admixture of T. harzianum, Y. schidigera root extract, Y. schidigera leaf extract, and X. spp. extract. The composition is also efficacious as a pre-infection agent for enhancing the resistance of agriculture crops to such infections. The composition is preferably applied by spraying.

Abstract: An automatic tissue sampling apparatus for use with a biopsy needle set having an inner needle and an outer cannula is provided. The apparatus includes a slidably disposed, spring-biased carrier for each of the inner needle and cannula A cocking mechanism is operable to sequentially move the first carrier to its cocked position and the second carrier to its cocked position. The cocking mechanism includes a manually operated cocking lever positioned outside the housing for single handed manipulation while holding the housing. A force transmission mechanism is operably coupled between the cocking lever and the carriers and configured so that the force required to manually depress the cocking lever to force the springs to the cocked positions does not increase as the springs are compressed.

Abstract: The invention relates to a method of clustering a set of proteins based on the sequence similarities of functional domain(s) such as pocket(s), functional site(s), allosteric site(s), and active site(s). The functional domain(s) of a protein sequence are identified based on the three-dimensional structure of the protein. Proteins are clustered based on the sequence similarity of the amino acid residues of the functional domain(s) and represented as a dendrogram. Proteins in a particular cluster show similar interaction patterns with specific drugs. Methods for identifying modulators for drug discovery based on the similarities of the functional domain(s) are provided.

Abstract: In a method and a system the autonomic nervous system, and in particular parameters reflecting the current condition of the autonomic nervous system, are monitored for detecting a lower level of wakefulness. One such parameter, which has been found to indicate such a state, is cardiac oscillation. Thus, the autonomic nervous system affect the heartbeat of a person falling to sleep in such a way that the heartbeat will go through a series of acceleration and de-acceleration.

Abstract: For estimating a person's age and for providing an emergency alarm function, a stationary pressure sensitive means (2, 3, 4) contacts part of that person's (1) body, and generates a signal in correspondence to that person's body movements relative to said means. A detector/filter circuit (5) connected to said means, separates signals corresponding to true body movements, heartbeat-related body movements, and respiration-related body movements. Calculation and comparison circuits (6, 9; 7, 10; 8, 11) are adapted to receive these signals and compare them with previously received signals to determine possible changes. A correlator (12) correlates the output signals from the calculation and comparison circuits to produce a resulting change signal which is compared with a preset threshold in a threshold detector circuit (13). The output signals can be used for activating/inactivating an air-bag system or for triggering an emergency alarm via a mobile telephone and a GPS system.