Patents Assigned to Biotage, Inc.
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Patent number: 6802968Abstract: An apparatus for use in liquid chromatography involves a column filled with media bounded axially by first and second porous plates. The column has an inlet end with an inflow region between the inlet end and the first porous plate. The column also has an outlet end with an outflow region between the outlet end and the second porous plate. The inflow region may be substantially longer than the outflow region. The porous plates may be moveable under pressure so as to compress the media.Type: GrantFiled: June 14, 2002Date of Patent: October 12, 2004Assignee: Biotage, Inc.Inventors: Peter J. Leavesley, Peter C. Van Davelaar, Robert D. Lockman, Ivan Hargro, Jeffrey A. Horsman, Peter C. Rahn
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Patent number: 6783673Abstract: Apparatus for chromatography, featuring a composite chromatography column including a tubular member having an inlet end and an outlet end, where the tubular member includes an innermost first layer comprised of a first material and a second layer comprised of a second material. The chromatography apparatus can also include a first intermediate layer formed from a third material, where at least a portion of the first intermediate layer is disposed between the innermost first layer and the second layer. A second intermediate layer formed from a fourth material, can further be included in the chromatography apparatus, where at least a portion of the second intermediate layer is disposed between the innermost first layer and the second layer. A portion of the second intermediate layer can be disposed between the second layer and the first intermediate layer.Type: GrantFiled: August 23, 2002Date of Patent: August 31, 2004Assignee: Biotage, Inc.Inventors: Jeffrey A. Horsman, Peter C. Van Davelaar
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Publication number: 20030222004Abstract: A chromatography system including a chromatography column connected to receive a sample and separate different compounds in the sample, a flow-through detector that outputs a signal indicating the presence of compounds in the sample leaving the column, a fraction collector that directs fractions of the sample from the column to separate fraction wells, and an electronic controller that receives inputs from the detector and controls the fraction collector. The electronic controller monitors the signal from the detector over time and initiates a cut from one well to another at the fraction collector when the signal over time experiences a shoulder where the slope of the signal over time does not change in sign but does change by more than a predetermined amount.Type: ApplicationFiled: May 14, 2003Publication date: December 4, 2003Applicant: Biotage, Inc.Inventors: Jonathan D. Michel, Robert W. Albrecht
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Patent number: 6652746Abstract: A chromatography system including a chromatography column connected to receive a sample and separate different compounds in the sample, a flow-through detector that outputs a signal indicating the presence of compounds in the sample leaving the column, a fraction collector that directs fractions of the sample from the column to separate fraction wells, and an electronic controller that receives inputs from the detector and controls the fraction collector. The electronic controller monitors the signal from the detector over time and initiates a cut from one well to another at the fraction collector when the signal over time experiences a shoulder where the slope of the signal over time does not change in sign but does change by more than a predetermined amount.Type: GrantFiled: March 26, 2002Date of Patent: November 25, 2003Assignee: Biotage, Inc.Inventors: Jonathan D. Michel, Robert U. Albrecht, Jr.
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Patent number: 6649051Abstract: A method of processing a sample comprising introducing a sample into a flow-through device containing a porous solid media therein, and thereafter subjecting the device to microwave energy. Also disclosed is a flow through device including solid porous media therein and attached active components.Type: GrantFiled: May 1, 2002Date of Patent: November 18, 2003Assignee: Biotage, Inc.Inventors: Shahnaz Ghassemi Jamalabadi, Peter C. Rahn, Kelvin Hammond, Omar Mneimne, Jeffrey A. Horsman
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Patent number: 6436284Abstract: An apparatus for use in liquid chromatography involves a column filled with media bounded axially by at least one porous member. The column has an inlet end with an inflow region between the inlet and a porous member. The inflow region may be sufficiently long so that a chromatography sample module may be disposed therein. The column may be sufficiently long so that a chromatography sample module may be disposed therein. The column may also have an outlet end with an outflow region between the outlet end and a second porous member. The inflow region may be substantially longer than the outflow region. The porous members may be moveable relative to the column.Type: GrantFiled: October 13, 2000Date of Patent: August 20, 2002Assignee: Biotage, Inc.Inventors: Peter J. Leavesley, Peter C. Van Davelaar, Robert D. Lockman, Ivan Hargo, Jeffrey A. Horsman, Peter C. Rahn
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Patent number: 4900537Abstract: A process is disclosed for the control of the particle form of aluminum hydroxide crystals precipitated from an alkali metal aluminate solution which comprises either the use of certain monohydric and polyhydric alcohols or controlling the caustic concentration of the sodium aluminate solution or a combination whereby particles shapes may be produced principally comprising acicular form or principally comprising lamellar form, depending upon the caustic concentration of the alkali metal hydroxide and the vol. % of the alcohol.Type: GrantFiled: December 11, 1986Date of Patent: February 13, 1990Assignee: Biotage, Inc.Inventor: Richard B. Wilhelmy