Patents Assigned to Biotechnol S.A.
  • HUMAN MINI-ANTIBODY CYTOTOXIC FOR TUMOR CELLS WHICH EXPRESS THE ERBB2 RECEPTOR
    Publication number: 20100173978
    Abstract: The invention refers to a fully human miniantibody (scFv), called Erbicin, specific for the receptor ErbB2, with a pharmacological, in particular antitumour, activity. It has been obtained from a larger fagmidic library (Griffin 1.) (19) of human synthetic scFv by panning (affinity selection on antigen) carried out on live cells that express various levels of ErbB2. The invention relates also to the DNA and amino acid sequences of said antibody, to the procedure for isolating it, to its use in therapy.
    Type: Application
    Filed: July 20, 2009
    Publication date: July 8, 2010
    Applicant: BIOTECHNOL, S.A.
    Inventors: Giuseppe D'Alessio, Renata Piccoli, Claudia De Lorenzo, Donald Balfour Palmer, Mary Alice Ritter
  • Human mini-antibody cytotoxic for tumor cells which express the ErbB2 receptor
    Patent number: 7585952
    Abstract: The invention refers to a fully human miniantibody (scFv), called Erbicin, specific for the receptor ErbB2, with a pharmacological, in particular antitumour, activity. It has been obtained from a larger fagmidic library (Griffin 1.) (19) of human synthetic scFv by panning (affinity selection on antigen) carried out on live cells that express various levels of ErbB2. The invention relates also to the DNA and aniino acid sequences of said antibody, to the procedure for isolating it, to its use in therapy.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: September 8, 2009
    Assignee: Biotechnol S.A.
    Inventors: Giuseppe D'Alessio, Renata Piccoli, Claudia De Lorenzo, Donald Balfour Palmer, Mary Alice Ritter