Patents Assigned to Biotechnology, Inc.
  • Patent number: 11453867
    Abstract: The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR systems, components, and methods for targeted modification of nucleic acids. Each system includes one or more protein components and one or more nucleic acid components that together target nucleic acids.
    Type: Grant
    Filed: October 19, 2021
    Date of Patent: September 27, 2022
    Assignee: ARBOR BIOTECHNOLOGIES, Inc.
    Inventors: David A. Scott, David R. Cheng, Winston X. Yan, Tia M. DiTommaso
  • Patent number: 11452757
    Abstract: A pharmaceutical composition for treating Gram negative bacteria-associated infections includes an antibacterial protein that includes at least one selected from the group of a protein having the amino acid sequence as set forth in SEQ ID NO: 1, a protein having the amino acid sequence as set forth in SEQ ID NO: 2, a protein having the amino acid sequence as set forth in SEQ ID NO: 3, a protein having the amino acid sequence as set forth in SEQ ID NO: 4, a protein having the amino acid sequence as set forth in SEQ ID NO: 5, a protein having the amino acid sequence as set forth in SEQ ID NO: 6, a protein having the amino acid sequence as set forth in SEQ ID NO: 7, and a protein having the amino acid sequence as set forth in SEQ ID NO: 8. A method of preparing the antibacterial protein is also disclosed.
    Type: Grant
    Filed: February 25, 2021
    Date of Patent: September 27, 2022
    Assignee: iNtRON Biotechnology, Inc.
    Inventors: Seong Jun Yoon, Soo Youn Jun, Jeong Won Park, Ji Hyun Kim, Saet Byeol Kim, Sang Hyeon Kang
  • Publication number: 20220299467
    Abstract: A structure usable in a molecular sensor device comprises a substrate defining a substrate plane and spaced apart pairs of reducible metal oxide or metal nitride sheets attached to the substrate at an angle to the substrate plane. The structure further includes intervening dielectric sheets. Fabrication methods for manufacturing structures for molecular sensors are disclosed comprising oblique angle deposition of reducible metal oxide or metal nitride and dielectric layers, planarization of the resulting stack, and reduction of portions of the reducible metal oxide or metal nitride sheets to the corresponding base metal.
    Type: Application
    Filed: August 18, 2020
    Publication date: September 22, 2022
    Applicant: Roswell Biotechnologies, Inc.
    Inventors: Sungho Jin, Barry Merriman, Tim Geiser, Paul W. Mola
  • Publication number: 20220296572
    Abstract: Provided are methods and uses related to cardiomyocyte cell therapies involving the administration of immunosuppressive agents for reducing or preventing rejection of administered allogeneic cardiomyocytes. In some embodiments, the methods are for treating a subject with a heart disease or condition in combination with a cardiomyocyte cell therapy.
    Type: Application
    Filed: March 2, 2022
    Publication date: September 22, 2022
    Applicant: Sana Biotechnology, Inc.
    Inventors: Robert Scott THIES, Charles E. MURRY
  • Patent number: 11445722
    Abstract: A kit, including: a first solution, a second solution, and a metal mesh. The first solution includes: dulbecco's modified eagle medium (DMEM), 65-95 V/V %; dimethyl sulfoxide (DMSO), 5.5-20 V/V %; ethylene glycol (EG), 3.5-15 V/V %; bovine serum albumin (BSA), 0.5-4 W/V %; sucrose 1-5 W/V %; methylcellulose with a viscosity of 4000 centipoise (cP), 0.05-0.8 W/V %; hetastarch 0.25-0.6 W/V %; and glucose 15-35 W/V %. The second solution includes: DMEM, 65-95 V/V %; DMSO, 5.5-20 V/V %; EG, 8-20 V/V %; BSA, 0.5-4 W/V %; sucrose, 10-20 W/V %; methylcellulose with a viscosity of 4000 centipoise (cP), 0.05-0.8 W/V %; polyvinyl pyrrolidone (PVP), 0.25-0.6 W/V %; and glucose 15-35 W/V %. The metal mesh has a thickness of 0.15-0.2 mm and includes a plurality of square holes. The side length of the square holes is 2.0-3.0 mm, and the spacing between adjacent holes is 0.5-2.0 mm.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: September 20, 2022
    Assignee: SHANGHAI CELLIVER BIOTECHNOLOGY INC.
    Inventors: Hongping Wu, Min Zeng, Xu Zhou, Xiaofang Jin, Qiurui Yang
  • Patent number: 11447771
    Abstract: The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR-Cas systems, components, and methods for targeted modification of nucleic acids such as DNA. Each system includes one or more protein components and one or more nucleic acid components that together target nucleic acids.
    Type: Grant
    Filed: October 20, 2021
    Date of Patent: September 20, 2022
    Assignee: ARBOR BIOTECHNOLOGIES, Inc.
    Inventors: David R. Cheng, David A. Scott, Winston X. Yan
  • Patent number: 11448639
    Abstract: A DNA or genome sequencing structure is disclosed. The structure includes an electrode pair, each electrode having a tip-shaped end, the electrodes separated by a nanogap defined by facing tip-shaped ends; at least one conductive island deposited at or near each tip-shaped end; and a biomolecule having two ends, each end attached to the conductive islands in the electrode pair such that one biomolecule bridges over the nanogap in the electrode pair, wherein nucleotide interactions with the biomolecule provides electronic monitoring of DNA or genome sequencing without the use of a fluorescing element.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: September 20, 2022
    Assignee: Roswell Biotechnologies, Inc.
    Inventors: Chulmin Choi, Sungho Jin, Paul W. Mola, Barry L. Merriman
  • Patent number: 11448647
    Abstract: Methods and systems for identifying a protein within a sample are provided herein. A panel of antibodies are acquired, none of which are specific for a single protein or family of proteins. Additionally, the binding properties of the antibodies in the panel are determined. Further, the protein is iteratively exposed to a panel of antibodies. Additionally, a set of antibodies which bind the protein are determined. The identity of the protein is determined using one or more deconvolution methods based on the known binding properties of the antibodies to match the set of antibodies to a sequence of a protein.
    Type: Grant
    Filed: November 23, 2021
    Date of Patent: September 20, 2022
    Assignee: NAUTILUS BIOTECHNOLOGY, INC.
    Inventor: Parag Mallick
  • Publication number: 20220288187
    Abstract: A hepatitis B virus (HBV) vaccine includes an HBV core antigen (HBcAg) and/or HBV surface antigen (HBsAg) formulated in nanocomplexes. The nanocomplexes contain chitosan and ?-PGA. These nanocomplexes containing HBc/sAg, chitosan, and ?-PGA can induce more balanced T helper cells (Th1 and Th2) polarization than can a conventional vaccine with an alum adjuvant. HBc/s-NC of the invention can elicit high levels of antibodies against HBsAg, a rapid elimination of HBsAg, and a slow decrease of HBeAg, indicating a phenomenon of HBsAg seroconversion. Thus, HBc/s-NC can overcome immune tolerance caused by chronic HBV infection to re-establish host immunity leading a functional cure.
    Type: Application
    Filed: September 23, 2020
    Publication date: September 15, 2022
    Applicant: Ascendo Biotechnology, Inc.
    Inventors: Ping-Yen HUANG, Frank Wen-Chi LEE, Yu-Hung CHEN, Yan-Wei WU
  • Patent number: 11440003
    Abstract: A method of manufacturing a device useable in DNA or genome sequencing comprises disposing pairs of electrodes on a substrate, the electrodes within each pair separated by a nanogap; depositing a resist layer over the electrodes; patterning the resist layer to create an exposed region on each electrode at or near each nanogap; roughening the electrode surface within each exposed region using various methods; and exposing the exposed regions to biomolecules, wherein one biomolecule bridges each nanogap of each electrode pair, with each end of each biomolecule bound to the electrodes at each exposed region.
    Type: Grant
    Filed: June 25, 2020
    Date of Patent: September 13, 2022
    Assignee: ROSWELL BIOTECHNOLOGIES, INC.
    Inventors: Chulmin Choi, Sungho Jin, Paul W. Mola, Barry L. Merriman
  • Publication number: 20220282311
    Abstract: A molecular electronics sensor capable of performing genetic analysis is described. In various embodiments, the sensor comprises spaced-apart electrodes, a bridge molecule coupled to the electrodes, and an oligonucleotide hybridization probe conjugated to the bridge molecule. The hybridization probe may comprise an oligonucleotide sequence complementary to a segment of a pathogen genome to be detected. In various aspects, a plurality of such sensors are disposed as an array of pixels on a CMOS chip. Sensors herein can be configured to detect a segment of SARS-CoV-2 genome in a bio-sample.
    Type: Application
    Filed: September 15, 2021
    Publication date: September 8, 2022
    Applicant: Roswell Biotechnologies, Inc.
    Inventors: Carl Fuller, Barry Merriman, Paul W. Mola, Hadi Abderrahim, Andrew Hodges
  • Patent number: 11427825
    Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as drug compounds, such as levamisole and cocaine.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: August 30, 2022
    Assignee: Base Pair Biotechnologies, Inc.
    Inventors: George W. Jackson, Robert Batchelor, Truong Nguyen, Rafal Drabek, Alexander S. Chiu, Deepak Thirunavukarasu, Vinoth Sankarapani
  • Patent number: 11427931
    Abstract: Provided are mutant viral capsid cell libraries, individual cells of such libraries, systems, vectors, and methods for generating the cell libraries, and methods of use thereof to screen for mutant viral capsids with desired characteristics.
    Type: Grant
    Filed: January 23, 2020
    Date of Patent: August 30, 2022
    Assignee: Adverum Biotechnologies, Inc.
    Inventors: Christopher Chavez, Mehdi Gasmi, Annahita Keravala, Thomas W. Chalberg
  • Patent number: 11420956
    Abstract: The present disclosure relates to novel compounds, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions. In some embodiments, the compounds disclosed herein exhibit androgen receptor degradation activity.
    Type: Grant
    Filed: September 22, 2020
    Date of Patent: August 23, 2022
    Assignee: Accutar Biotechnology Inc.
    Inventors: Jie Fan, Yimin Qian, Wei He, Ke Liu
  • Publication number: 20220259207
    Abstract: The present disclosure relates to novel compounds that degrade Bruton's tyrosine kinase (BTK), pharmaceutical compositions containing such compounds, and their use in prevention and treatment of conditions modulated by BTK.
    Type: Application
    Filed: February 2, 2022
    Publication date: August 18, 2022
    Applicant: ACCUTAR BIOTECHNOLOGY INC.
    Inventors: Yimin Qian, Wei He, Robert Luo, JIE SU, HUI ZHANG, KE LIU, JIE FAN
  • Publication number: 20220252542
    Abstract: The disclosed embodiments relate to nanotechnology and to nano-electronics and molecular electronic sensors. In an exemplary embodiment, a nano-sensor having a nanoparticle complex attached at each end to a respective nano-electrode. An exemplary nanoparticle complex includes a biomolecule coupled at each end to a metallic nanoparticle to form a dumbbell-shaped molecular bridge.
    Type: Application
    Filed: January 13, 2022
    Publication date: August 11, 2022
    Applicant: Roswell Biotechnologies, Inc.
    Inventors: Barry Merriman, Sonal Jain, Drew Kennedy, Venkatesh Alagarswamy Govindaraj, Calvin Gardner, Chulmin Choi, Namseok Park, Richard Dubielzig, Le Zheng, David Porras, Paul Pan
  • Publication number: 20220241328
    Abstract: Provided herein are methods of transducing resting or non-activated T cells using CD8-targeted viral vectors.
    Type: Application
    Filed: January 10, 2022
    Publication date: August 4, 2022
    Applicant: Sana Biotechnology, Inc.
    Inventors: Christopher BANDORO, Patricia CRUITE, Kutlu ELPEK, Akinola Olumide EMMANUEL, Lauren Pepper MACKENZIE, Jagesh Vijaykumar SHAH, Kyle Marvin TRUDEAU
  • Publication number: 20220233595
    Abstract: Provided herein are compositions and methods for treating T cell exhaustion in a subject, by administering a PTD-MYC fusion protein (e.g., an HIV TAT-MYC fusion protein) or immune cells treated with a PTD-MYC fusion protein. Kits for use in practicing the methods are also provided herein.
    Type: Application
    Filed: May 13, 2020
    Publication date: July 28, 2022
    Applicant: TAIGA BIOTECHNOLOGIES, INC.
    Inventors: Yosef REFAELI, Brian C. Turner, Thomas R. PAYNE
  • Publication number: 20220238191
    Abstract: The present disclosure provides methods and apparatuses for molecular modeling with machine-learned universal potential functions. An exemplary method includes: determining a data structure representing chemical identities of atoms in a molecule; training an energy potential model using a training set comprising the data structure, true conformations of the molecule, and false conformations of the molecule; determining, using the trained energy potential model, a potential function associated with the molecule; or determining a conformation of the molecule based on potential function.
    Type: Application
    Filed: January 28, 2022
    Publication date: July 28, 2022
    Applicant: ACCUTAR BIOTECHNOLOGY INC.
    Inventors: Jie FAN, Ke LIU, Xiangyan SUN
  • Publication number: 20220220124
    Abstract: Compounds, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and other related diseases and conditions are disclosed.
    Type: Application
    Filed: April 17, 2020
    Publication date: July 14, 2022
    Applicant: ACCUTAR BIOTECHNOLOGY INC.
    Inventors: Jie FAN, Wei HE, Ke LIU