Abstract: The present disclosure relates to a composition comprising a complex that includes a curcuminoid-based compound and a steviol glycoside, or a curcuminoid-based compound and a licorice extract or a fraction thereof; and a use of the composition for enhancement of immunity according to an enhancement of activity or a cell number of immune cells and/or a use of the composition for prevention, improvement, or treatment of COVID-19. The complex including curcumin and a steviol glycoside, or a licorice extract or a fraction thereof according to the present disclosure, which are food materials that have been registered with the Ministry of Food and Drug Safety and have received the Generally Recognized as Safe (GRAS) rating from the U.S. FDA, and whose safety has already been confirmed, inhibits symptoms of COVID-19 by activating Th1 cells, CD8 T cells, and NK cells. Therefore, the complex can be provided as a food and pharmaceutical composition for preventing, improving, or treating COVID-19.