Abstract: This disclosure provides, in one aspect, dosing strategies for soluble ?-glucan immunotherapy to optimize acute immunopharmacodynamic responses for the immunotherapy and/or subject. It also provides a method for analyzing a sample from a subject for a biomarker to identify the appropriate dosing strategy for soluble ?-glucan immunotherapy. Generally, the method includes obtaining a biological sample from a subject, analyzing the sample for a biomarker anti-?-glucan antibody level or immunopharmacodynamic response level, classifying the subject into a subgroup based on the biomarker anti-?-glucan antibody level or immunopharmacodynamic response level and identifying the appropriate dosing strategy based on the subgroup classification.
Type:
Application
Filed:
February 23, 2018
Publication date:
January 30, 2020
Applicant:
BIOTHERA PHARMACEUTICALS, INC.
Inventors:
Nandita BOSE, Nadine OTTOSON, Ben HARRISON, Jamie LOWE, Mark UHLIK, Jeremy GRAFF, Richard HUHN