Patents Assigned to Biovec Transfusion, LLC
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Patent number: 9095818Abstract: The present invention relates to methods for removing antiplatelet agents and anticoagulants from a platelet preparation. In one embodiment, the method includes the step of flowing the platelet preparation through a filtering tube comprising a filtering membrane and separating the antiplatelet agents and anticoagulants from the platelet preparation by tangential flow filtration. In another embodiment, the method includes the step of passing the platelet preparation through porous material that specifically binds to the antiplatelet agents and anticoagulants.Type: GrantFiled: June 2, 2010Date of Patent: August 4, 2015Assignee: BIOVEC TRANSFUSION, LLCInventor: Lakshman R. Sehgal
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Patent number: 8927203Abstract: The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally, the composition may also contain an ultra-short acting broad spectrum anti-microbial agents. The preservative composition may be used to store platelets in a liquid state, a frozen state, or a freeze-dried state.Type: GrantFiled: October 21, 2011Date of Patent: January 6, 2015Assignee: Biovec Transfusion, LLCInventor: Lakshman R. Sehgal
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Patent number: 8877060Abstract: The present application relates to a method for removing pathogens from a transfusion grade platelet composition. The method comprises the steps of passing a platelet preparation through a first tangential flow filtration (TFF) device having a TFF filter, and collecting a retentate from the TFF device, wherein the retentate comprises filtered platelets to be used for transfusion. The platelet preparation comprises a platelet activation inhibitor and an anti-coagulant. During the TFF process, a diafiltration solution is added to the retentate to maintain the volume of the platelets.Type: GrantFiled: October 31, 2011Date of Patent: November 4, 2014Assignee: Biovec Transfusion, LLCInventor: Lakshman R. Sehgal
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Patent number: 8715920Abstract: A platelet preservation composition is disclosed. The composition comprises a photosensitizer, an inhibitor of platelet activation, and/or an anticoagulant. The preservation composition allows inactivation of pathogens in a platelet preparation while maintaining the functionality of the platelets.Type: GrantFiled: July 11, 2011Date of Patent: May 6, 2014Assignee: Biovec Transfusion, LLCInventor: Lakshman R. Sehgal
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Patent number: 8697347Abstract: The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally, the composition may also contain an ultra-short acting broad spectrum anti-microbial agents. The preservative composition may be used to store platelets in a liquid state, a frozen state, or a freeze-dried state.Type: GrantFiled: April 29, 2011Date of Patent: April 15, 2014Assignee: Biovec Transfusion, LLCInventor: Lakshman R. Sehgal
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Patent number: 8470521Abstract: The present invention relates to methods for removing antiplatelet agents and anticoagulants from a platelet preparation. In one embodiment, the method includes the step of flowing the platelet preparation through a filtering tube comprising a filtering membrane and separating the antiplatelet agents and anticoagulants from the platelet preparation by tangential flow filtration. In another embodiment, the method includes the step of passing the platelet preparation through porous material that specifically binds to the antiplatelet agents and anticoagulants.Type: GrantFiled: July 31, 2012Date of Patent: June 25, 2013Assignee: Biovec Transfusion, LLCInventor: Lakshman R. Sehgal
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Patent number: 8431334Abstract: The present invention relates to methods for preserving platelet. In one embodiment, the method includes the steps of mixing platelets with a platelet preservation composition to form a platelet preparation, storing the platelet preparation for a desired period of time, and removing the antiplatelet agent and the anticoagulant from the platelet preparation by diafiltration prior to transfusion of the platelets. The platelet preservation composition comprises an effective amount of an antiplatelet agent and an effective amount of an anticoagulant.Type: GrantFiled: November 29, 2010Date of Patent: April 30, 2013Assignee: Biovec Transfusion, LLCInventor: Lakshman R. Sehgal
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Publication number: 20130040282Abstract: A method for removing a photosensitizer from a platelet preservation composition is disclosed. The method comprises passing the platelet preservation composition through a tangential flow filtration device to separate the photosensitizer from the platelets in the platelet preservation composition.Type: ApplicationFiled: September 25, 2012Publication date: February 14, 2013Applicant: BIOVEC TRANSFUSION, LLCInventor: Lakshman R. Sehgal
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Publication number: 20120315619Abstract: The present invention relates to methods for removing antiplatelet agents and anticoagulants from a platelet preparation. In one embodiment, the method includes the step of flowing the platelet preparation through a filtering tube comprising a filtering membrane and separating the antiplatelet agents and anticoagulants from the platelet preparation by tangential flow filtration. In another embodiment, the method includes the step of passing the platelet preparation through porous material that specifically binds to the antiplatelet agents and anticoagulants.Type: ApplicationFiled: July 31, 2012Publication date: December 13, 2012Applicant: BIOVEC TRANSFUSION, LLCInventor: Lakshman R. SEHGAL
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Patent number: 8329389Abstract: The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally, the composition may also contain an ultra-short acting broad spectrum anti-microbial agents. The preservative composition may be used to store platelets in a liquid state, a frozen state, or a freeze-dried state.Type: GrantFiled: April 29, 2011Date of Patent: December 11, 2012Assignee: Biovec Transfusion, LLCInventor: Lakshman R. Sehgal
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Patent number: 8232044Abstract: The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally, the composition may also contain an ultra-short acting broad spectrum anti-microbial agents. The preservative composition may be used to store platelets in a liquid state, a frozen state, or a freeze-dried state.Type: GrantFiled: May 2, 2011Date of Patent: July 31, 2012Assignee: Biovec Transfusion, LLCInventor: Lakshman R. Sehgal
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Publication number: 20120157905Abstract: The present application relates to a system and method for treating carbon monoxide poisoning. The system and method comprises passing the blood of a subject in need of such treatment through a filter unit comprising a gas permeable membrane to remove carbon monoxide from the blood by filtration against an extraction fluid enriched with oxygen and/or by exposure to one or more agents suitable for removing carbon monoxide or converting carbon monoxide to carbon dioxide, which is more readily exchangeable with oxygen compared to carbon monoxide.Type: ApplicationFiled: November 7, 2011Publication date: June 21, 2012Applicant: BIOVEC TRANSFUSION, LLCInventor: Lakshman R. SEHGAL
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Publication number: 20120134974Abstract: A method for preparing a blood component composition for reducing risk of transfusion related injury includes passing a blood component composition through a tangential flow filter unit comprising one or more filter membranes. A diafiltration solution is added to the blood component composition during the filtration process. Non-cellular plasma components, including antibodies, are removed from the blood component composition by the tangential flow filtration.Type: ApplicationFiled: October 26, 2011Publication date: May 31, 2012Applicant: BIOVEC TRANSFUSION, LLCInventor: Lakshman R. Sehgal
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Publication number: 20120125847Abstract: The present application relates to a method for removing pathogens from a transfusion grade platelet composition. The method comprises the steps of passing a platelet preparation through a first tangential flow filtration (TFF) device having a TFF filter, and collecting a retentate from the TFF device, wherein the retentate comprises filtered platelets to be used for transfusion. The platelet preparation comprises a platelet activation inhibitor and an anti-coagulant. During the TFF process, a diafiltration solution is added to the retentate to maintain the volume of the platelets.Type: ApplicationFiled: October 31, 2011Publication date: May 24, 2012Applicant: BIOVEC TRANSFUSION, LLCInventor: Lakshman R. Sehgal
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Patent number: 8142992Abstract: The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally, the composition may also contain an ultra-short acting broad spectrum anti-microbial agents. The preservative composition may be used to store platelets in a liquid state, a frozen state, or a freeze-dried state.Type: GrantFiled: May 8, 2009Date of Patent: March 27, 2012Assignee: Biovec Transfusion, LLCInventors: Lakshman R. Sehgal, Shaker Mousa
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Publication number: 20120058558Abstract: The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally, the composition may also contain an ultra-short acting broad spectrum anti-microbial agents. The preservative composition may be used to store platelets in a liquid state, a frozen state, or a freeze-dried state.Type: ApplicationFiled: October 21, 2011Publication date: March 8, 2012Applicant: BIOVEC TRANSFUSION, LLCInventor: Lakshman R. Sehgal
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Patent number: 8129103Abstract: The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally, the composition may also contain an ultra-short acting broad spectrum anti-microbial agents. The preservative composition may be used to store platelets in a liquid state, a frozen state, or a freeze-dried state.Type: GrantFiled: April 25, 2008Date of Patent: March 6, 2012Assignee: Biovec Transfusion, LLCInventors: Lakshman R. Sehgal, Shaker Mousa
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Patent number: 8129104Abstract: The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally, the composition may also contain an ultra-short acting broad spectrum anti-microbial agents. The preservative composition may be used to store platelets in a liquid state, a frozen state, or a freeze-dried state.Type: GrantFiled: May 11, 2009Date of Patent: March 6, 2012Assignee: Biovec Transfusion, LLCInventors: Lakshman R. Sehgal, Shaker Mousa
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Publication number: 20120028236Abstract: A platelet preservation composition is disclosed. The composition comprises a photosensitizer, an inhibitor of platelet activation, and/or an anticoagulant. The preservation composition allows inactivation of pathogens in a platelet preparation while maintaining the functionality of the platelets.Type: ApplicationFiled: July 11, 2011Publication date: February 2, 2012Applicant: BIOVEC TRANSFUSION, LLCInventor: Lakshman R. SEHGAL
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Publication number: 20110223579Abstract: The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally, the composition may also contain an ultra-short acting broad spectrum anti-microbial agents. The preservative composition may be used to store platelets in a liquid state, a frozen state, or a freeze-dried state.Type: ApplicationFiled: May 2, 2011Publication date: September 15, 2011Applicant: BIOVEC TRANSFUSION, LLCInventor: Lakshman R. SEHGAL