Patents Assigned to Biovest International, Inc.
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Patent number: 11345882Abstract: An extra-capillary fluid cycling unit for maintaining and cycling fluid volumes in a cell culture chamber includes a housing and a first flexible reservoir extra-capillary fluid reservoir disposed in the housing. The extra-capillary fluid reservoir is in fluid communication with a cell culture chamber. A second flexible reservoir is also located in the housing, the second flexible reservoir being in fluid communication with a pressure source. A sensor plate is movably disposed in the housing between the extra-capillary reservoir and the second reservoir, wherein the second reservoir is pressurized to move the sensor plate in relation to the extra-capillary reservoir to cause fluid cycling and maintain fluid volumes in the cell growth chamber.Type: GrantFiled: August 24, 2016Date of Patent: May 31, 2022Assignee: BIOVEST INTERNATIONAL, INC.Inventors: Darrell Paul Page, Robert J. Wojciechowski, Martin Peder Crep
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Patent number: 10723993Abstract: A cell culture system for the production of cells and cell derived products includes a reusable instrumentation base device incorporating hardware to support cell culture growth. A disposable cultureware module including a cell growth chamber is removably attachable to the instrumentation base device. The base device includes microprocessor control and a pump for circulating cell culture medium through the cell growth chamber. The cultureware module is removably attached to the instrumentation base device. Cells are introduced into the cell growth chamber and a source of medium is fluidly attached to the cultureware module. Operating parameters are programmed into the microprocessor control. The pump is operated to circulate the medium through the cell growth chamber to grow cells or cell products therein. The grown cells or cell products are harvested from the cell growth chamber and the cultureware module is then disposed.Type: GrantFiled: August 24, 2016Date of Patent: July 28, 2020Assignee: BIOVEST INTERNATIONAL, INC.Inventors: Robert J. Wojciechowski, Darrell P. Page, Karl Patrick Bongers, Scott Waniger, Beverly Norris, Mark Hirschel, Thiem Chan Duong Wong, Grant Adams, Martin Peder Crep, Michael J. Gramer
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Patent number: 10662401Abstract: The present invention provides a production module for large-scale production of cells and/or cell-derived products such as antibodies or virus; a production suite comprising a plurality of functionally connected production modules of the invention; and a method for large-scale production of cells and/or cell-derived products using the production modules and/or production suites of the invention.Type: GrantFiled: January 31, 2018Date of Patent: May 26, 2020Assignee: BIOVEST INTERNATIONAL, INC.Inventors: Mark Hirschel, Robert J. Wojciechowski, Kim Arneson
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Patent number: 10570434Abstract: The subject invention pertains to methods and apparatus for the production and purification of cell products, such as immunoglobulins. One aspect of the invention is an integrated cell culture and purification apparatus for the growth and maintenance of cells and the harvest and purification of cell products, such as immunoglobulins. Thus, the apparatus integrates a cell culture function with a purification function. Other aspects of the invention pertain to an automated method for producing immunogenic compositions such as vaccines.Type: GrantFiled: January 31, 2018Date of Patent: February 25, 2020Assignee: BIOVEST INTERNATIONAL, INC.Inventors: Mark Hirschel, Robert J. Wojciechowski, Grant Adams, Darrell P. Page, Kimberly Arneson, Jeff Jorgensen, Scott Waniger
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Patent number: 10093956Abstract: The subject invention pertains to methods and apparatus for the production and purification of cell products, such as immunoglobulins. One aspect of the invention is an integrated cell culture and purification apparatus for the growth and maintenance of cells and the harvest and purification of cell products, such as immunoglobulins. Thus, the apparatus integrates a cell culture function with a purification function. Other aspects of the invention pertain to an automated method for producing immunogenic compositions such as vaccines.Type: GrantFiled: October 17, 2014Date of Patent: October 9, 2018Assignee: BIOVEST INTERNATIONAL, INC.Inventors: Mark Hirschel, Robert J. Wojciechowski, Grant Adams, Darrell P. Page, Kimberly Arneson, Jeff Jorgensen, Scott Waniger
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Patent number: 9902928Abstract: The present invention provides a production module for large-scale production of cells and/or cell-derived products such as antibodies or virus; a production suite comprising a plurality of functionally connected production modules of the invention; and a method for large-scale production of cells and/or cell-derived products using the production modules and/or production suites of the invention.Type: GrantFiled: August 28, 2013Date of Patent: February 27, 2018Assignee: BIOVEST INTERNATIONAL, INC.Inventors: Mark Hirschel, Robert J. Wojciechowski, Kim Arneson
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Patent number: 9732313Abstract: The invention concerns a bioreactor for production of virus and virus-like particles (VLPs), methods for production of virus and VLPs, methods for regulating the concentration of molecules inhibitory to viral and VLP yield in a cell culture chamber of a bioreactor, such as the extracapillary space of a hollow fiber bioreactor.Type: GrantFiled: October 30, 2014Date of Patent: August 15, 2017Assignee: BIOVEST INTERNATIONAL, INC.Inventors: Mark Hirschel, Joseph David Gangemi
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Patent number: 9725768Abstract: The present invention concerns methods for selecting and producing idiotype vaccines, and in particular methods for selecting and producing an idiotype vaccine for treatment of a B-cell derived malignancy in a subject based on the clonal profile (clonotype) of the malignancy; a method for producing an updated idiotype vaccine matched to a B-cell derived malignancy exhibiting a shifting clonal profile; and the high-fidelity idiotype vaccines produced using the methods. The invention also includes idiotype vaccines produced using the described methods and methods of treating B-cell derived malignancies using the produced vaccines.Type: GrantFiled: August 30, 2013Date of Patent: August 8, 2017Assignee: BIOVEST INTERNATIONAL, INC.Inventors: Carlos F. Santos, Amy M. Mccord, Mark Hirschel
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Patent number: 9534198Abstract: An extra-capillary fluid cycling unit for maintaining and cycling fluid volumes in a cell culture chamber includes a housing and a first flexible reservoir extra-capillary fluid reservoir disposed in the housing. The extra-capillary fluid reservoir is in fluid communication with a cell culture chamber. A second flexible reservoir is also located in the housing, the second flexible reservoir being in fluid communication with a pressure source. A sensor plate is movably disposed in the housing between the extra-capillary reservoir and the second reservoir, wherein the second reservoir is pressurized to move the sensor plate in relation to the extra-capillary reservoir to cause fluid cycling and maintain fluid volumes in the cell growth chamber.Type: GrantFiled: September 23, 2013Date of Patent: January 3, 2017Assignee: BIOVEST INTERNATIONAL, INC.Inventors: Darrell Paul Page, Robert J. Wojciechowski, Martin Peder Crep
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Patent number: 9441195Abstract: A cell culture system for the production of cells and cell derived products includes a reusable instrumentation base device incorporating hardware to support cell culture growth. A disposable cultureware module including a cell growth chamber is removably attachable to the instrumentation base device. The base device includes microprocessor control and a pump for circulating cell culture medium through the cell growth chamber. The cultureware module is removably attached to the instrumentation base device. Cells are introduced into the cell growth chamber and a source of medium is fluidly attached to the cultureware module. Operating parameters are programmed into the microprocessor control. The pump is operated to circulate the medium through the cell growth chamber to grow cells or cell products therein. The grown cells or cell products are harvested from the cell growth chamber and the cultureware module is then disposed.Type: GrantFiled: October 30, 2012Date of Patent: September 13, 2016Assignee: BIOVEST INTERNATIONAL, INC.Inventors: Robert J. Wojciechowski, Darrell P. Page, Karl Patrick Bongers, Scott Waniger, Beverly Norris, Mark Hirschel, Thiem Chan Duong Wong, Grant Adams, Martin Peder Crep, Michael J. Gramer
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Publication number: 20140140986Abstract: The present invention relates to compositions, kits, and methods useful for directing an immune response to an epitope of an antigen in a subject, by sensitizing the subject to the epitope and/or by tolerizing the subject to the epitope. The sensitizing method comprises co-administering to the subject the epitope and an immunoglobulin M (IgM) constant region (IgM Fc region). The tolerizing method comprises co-administering to the subject the epitope and an immunoglobulin G (IgG) constant region (IgG Fc region) to the subject.Type: ApplicationFiled: November 8, 2011Publication date: May 22, 2014Applicant: BIOVEST INTERNATIONAL, INC.Inventors: Carlos F. Santos, Mihaela Popa-Mckiver, Amy M. Mccord, Mark Hirschel
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Publication number: 20140037615Abstract: The present invention relates to compositions, kits, and methods for preparing an autologous idiotype vaccine, or autologous anti-idiotype vaccine, for treatment of a B-cell malignancy based on the isotype(s) (class(es)) of immunoglobulins expressed by the malignancy; methods for treating B-cell malignancies; and methods for selecting a treatment for a subject having a B-cell malignancy.Type: ApplicationFiled: August 12, 2011Publication date: February 6, 2014Applicant: BIOVEST INTERNATIONAL, INC.Inventors: Carlos F. Santos, Mihaela Popa-Mckiver, Amy M. McCord, Mark Hirschel
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Patent number: 8540499Abstract: An extra-capillary fluid cycling unit for maintaining and cycling fluid volumes in a cell culture chamber includes a housing and a first flexible reservoir extra-capillary fluid reservoir disposed in the housing. The extra-capillary fluid reservoir is in fluid communication with a cell culture chamber. A second flexible reservoir is also located in the housing, the second flexible reservoir being in fluid communication with a pressure source. A sensor plate is movably disposed in the housing between the extra-capillary reservoir and the second reservoir, wherein the second reservoir is pressurized to move the sensor plate in relation to the extra-capillary reservoir to cause fluid cycling and maintain fluid volumes in the cell growth chamber.Type: GrantFiled: November 20, 2008Date of Patent: September 24, 2013Assignee: Biovest International, Inc.Inventors: Darrell Paul Page, Robert J. Wojciechowski, Martin Peder Crep
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Publication number: 20130058907Abstract: A cell culture system for the production of cells and cell derived products includes a reusable instrumentation base device incorporating hardware to support cell culture growth. A disposable cultureware module including a cell growth chamber is removably attachable to the instrumentation base device. The base device includes microprocessor control and a pump for circulating cell culture medium through the cell growth chamber. The cultureware module is removably attached to the instrumentation base device. Cells are introduced into the cell growth chamber and a source of medium is fluidly attached to the cultureware module. Operating parameters are programmed into the microprocessor control. The pump is operated to circulate the medium through the cell growth chamber to grow cells or cell products therein. The grown cells or cell products are harvested from the cell growth chamber and the cultureware module is then disposed.Type: ApplicationFiled: October 30, 2012Publication date: March 7, 2013Applicant: BIOVEST INTERNATIONAL, INC.Inventor: Biovest International, Inc.
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Patent number: 8383397Abstract: A cell culture system for the production of cells and cell derived products includes a reusable instrumentation base device incorporating hardware to support cell culture growth. A disposable cultureware module including a cell growth chamber is removably attachable to the instrumentation base device. The base device includes microprocessor control and a pump for circulating cell culture medium through the cell growth chamber. The cultureware module is removably attached to the instrumentation base device. Cells are introduced into the cell growth chamber and a source of medium is fluidly attached to the cultureware module. Operating parameters are programmed into the microprocessor control. The pump is operated to circulate the medium through the cell growth chamber to grow cells or cell products therein. The grown cells or cell products are harvested from the cell growth chamber and the cultureware module is then disposed.Type: GrantFiled: November 20, 2008Date of Patent: February 26, 2013Assignee: Biovest International, Inc.Inventors: Robert J. Wojciechowski, Darrell P. Page, Karl P. Bongers, Scott T. Waniger, Beverly Norris, Mark D. Hirschel, Thiem Chan Duong Wong, Martin P. Crep, Michael J. Gramer, Grant Adams
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Publication number: 20120114634Abstract: The present invention relates to methods of inducing and maintaining an immune response against a B-cell idiotype in a subject using an autologous anti-idiotypic vaccine. In one embodiment, the immune response is induced and maintained for treatment of a B-cell derived malignancy selected from among non-Hodgkin's lymphoma. Hodgkin's lymphoma, chronic lymphocytic leukemia, multiple myeloma, and mantle cell lymphoma.Type: ApplicationFiled: November 21, 2011Publication date: May 10, 2012Applicant: BIOVEST INTERNATIONAL, INC.Inventors: ANGELOS M. STERGIOU, FRANCIS E. O'DONNELL, JR., CARLOS SANTOS
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Publication number: 20110212493Abstract: The present invention includes perfusion bioreactors, automated cell culture systems, and methods for production of cells and cell-derived products.Type: ApplicationFiled: April 22, 2011Publication date: September 1, 2011Applicant: BIOVEST INTERNATIONAL, INC.Inventors: Mark HIRSCHEL, Darrell P. PAGE, Robert J. WOJCIECHOWSKI
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Publication number: 20090269841Abstract: A cell culture system for the production of cells and cell derived products includes a reusable instrumentation base device incorporating hardware to support cell culture growth. A disposable cultureware module including a cell growth chamber is removably attachable to the instrumentation base device. The base device includes microprocessor control and a pump for circulating cell culture medium through the cell growth chamber. The cultureware module is removably attached to the instrumentation base device. Cells are introduced into the cell growth chamber and a source of medium is fluidly attached to the cultureware module. Operating parameters are programmed into the microprocessor control. The pump is operated to circulate the medium through the cell growth chamber to grow cells or cell products therein. The grown cells or cell products are harvested from the cell growth chamber and the cultureware module is then disposed.Type: ApplicationFiled: November 20, 2008Publication date: October 29, 2009Applicant: Biovest International, Inc.Inventors: Robert J. Wojciechowski, Darrell Paul Page, Karl Patrick Bongers, Scott Thomas Waniger, Beverly Norris, Mark D. Hirschel, Thiem Chan Duong Wong, Martin Peder Crep, Michael J. Gramer, Grant Adams
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Publication number: 20090215022Abstract: An extra-capillary fluid cycling unit for maintaining and cycling fluid volumes in a cell culture chamber includes a housing and a first flexible reservoir extra-capillary fluid reservoir disposed in the housing. The extra-capillary fluid reservoir is in fluid communication with a cell culture chamber. A second flexible reservoir is also located in the housing, the second flexible reservoir being in fluid communication with a pressure source. A sensor plate is movably disposed in the housing between the extra-capillary reservoir and the second reservoir, wherein the second reservoir is pressurized to move the sensor plate in relation to the extra-capillary reservoir to cause fluid cycling and maintain fluid volumes in the cell growth chamber.Type: ApplicationFiled: November 20, 2008Publication date: August 27, 2009Applicant: Biovest International, Inc.Inventors: Darrell Paul Page, Robert J. Wojciechowski, Martin Peder Crep