Patents Assigned to BioVinc LLC
  • Bisphosphonate quinolone conjugates and uses thereof
    Patent number: 11840549
    Abstract: Described herein are bisphosphonate quinolone compounds, conjugates and pharmaceutical formulations thereof that can include a bisphosphonate and a quinolone, where the quinolone can be releasably coupled to the bisphosphonate. Also provided herein are methods of making and methods of using the bisphosphonate quinolone compounds, conjugates and pharmaceutical formulations thereof.
    Type: Grant
    Filed: December 11, 2020
    Date of Patent: December 12, 2023
    Assignees: BIOVINC, LLC, UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Frank H. Ebetino, Shuting Sun, Mark W. Lundy, Charles E. McKenna, Eric Richard, Parish Sedghizadeh, Keivan Sadrerafi, Philip T. Cherian
  • Bortezomib conjugates and methods using same
    Patent number: 11497813
    Abstract: The present invention provides compositions and methods for providing controllable local delivery of a conjugate of bortezomib (Btz) and a bisphosphonate to promote bone formation. In certain embodiments, the invention is used as a treatment for a subject with diseases and disorders characterized by bone loss.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: November 15, 2022
    Assignee: BIOVINC, LLC
    Inventors: Frank Ebetino, Robert Boeckman, Lianping Xing, Lifeng Xiao, Brendan Boyce
  • Skeletal removal of bisphosphonates
    Patent number: 11400104
    Abstract: Disclosed herein are methods and compositions for removing or displacing bisphosphonates in skeletal tissue.
    Type: Grant
    Filed: October 29, 2020
    Date of Patent: August 2, 2022
    Assignees: The Regents of the University of California, BioVinc LLC, University of Southern California
    Inventors: Frank Hallock Ebetino, Ichiro Nishimura, Shuting Sun, Mark Walden Lundy, Akishige Hokugo, Charles McKenna, Keivan Sadrerafi
  • Bisphosphonate quinolone conjugates and uses thereof
    Patent number: 10865220
    Abstract: Described herein are bisphosphonate quinolone compounds, conjugates and pharmaceutical formulations thereof that can include a bisphosphonate and a quinolone, where the quinolone can be releasably coupled to the bisphosphonate. Also provided herein are methods of making and methods of using the bisphosphonate quinolone compounds, conjugates and pharmaceutical formulations thereof.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: December 15, 2020
    Assignees: BIOVINC, LLC, UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Frank H. Ebetino, Shuting Sun, Mark W. Lundy, Charles E. McKenna, Eric Richard, Parish Sedghizadeh, Keivan Sadrerafi, Philip T. Cherian
  • Skeletal removal of bisphosphonates
    Patent number: 10857165
    Abstract: Disclosed herein are methods and compositions for removing or displacing bisphosphonates in skeletal tissue.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: December 8, 2020
    Assignees: The Regents of the University of California, BioVinc LLC, University of Southern California
    Inventors: Frank Hallock Ebetino, Ichiro Nishimura, Shuting Sun, Mark Walden Lundy, Akishige Hokugo, Charles McKenna, Keivan Sadrerafi