Abstract: Disclosed is an Ixodes ricinus salivary gland polypeptide and its use for inhibiting the extrinsic coagulation pathway and for treating and/or preventing diseases and conditions, such as thrombotic events, associated with the recruitment and activation of neutrophils following activation of the extrinsic coagulation pathway.

Abstract: Methods for treating brain inflammation, including brain inflammation occurring or susceptible to occur after brain hemorrhage, which include the administration of a protein or polypeptide including a polypeptide having at least 75% sequence identity with the amino acid sequence SEQ ID NO: 1, or a pharmaceutical composition including the protein or polypeptide. Also, a method for preventing, reducing, decreasing, and/or inhibiting neuronal death, which includes the administration of a protein or polypeptide including a polypeptide having at least 75% sequence identity with the amino acid sequence SEQ ID NO: 1, or a pharmaceutical composition including the protein or polypeptide.

Abstract: Methods for treating brain inflammation, including brain inflammation occurring or susceptible to occur after brain hemorrhage, which include the administration of a protein or polypeptide including a polypeptide having at least 75% sequence identity with the amino acid sequence SEQ ID NO: 1, or a pharmaceutical composition including the protein or polypeptide. Also, a method for preventing, reducing, decreasing, and/or inhibiting neuronal death, which includes the administration of a protein or polypeptide including a polypeptide having at least 75% sequence identity with the amino acid sequence SEQ ID NO: 1, or a pharmaceutical composition including the protein or polypeptide.

Abstract: Methods for treating brain inflammation, including brain inflammation occurring or susceptible to occur after brain hemorrhage, which include the administration of a protein or polypeptide including a polypeptide having at least 75% sequence identity with the amino acid sequence SEQ ID NO: 1, or a pharmaceutical composition including the protein or polypeptide. Also, a method for preventing, reducing, decreasing, and/or inhibiting neuronal death, which includes the administration of a protein or polypeptide including a polypeptide having at least 75% sequence identity with the amino acid sequence SEQ ID NO: 1, or a pharmaceutical composition including the protein or polypeptide.

Abstract: Disclosed is a fusion protein including an Ixodes ricinus salivary gland polypeptide. In particular, it relates to a fusion protein including at least one Ixodes ricinus salivary gland polypeptide, at least one serum albumin polypeptide and at least one linker peptide. Also disclosed is the use of such a fusion protein for preventing or treating thrombus formation and/or thrombus growth, as well as pharmaceutical compositions, medicaments and methods including such a fusion protein.