Publication number: 20090068673
Abstract: This invention is based upon the application of compatible solutes to immobilized biological materials or to immobilize in order to improve the technical performance using the same, namely nucleic acid and proteins or biosensors micronets. The above mentioned compatible solutes are selected from a group that includes Mannosylglycerate (MG) and its 3 derivatives manno-sylglyceramide (MGA), -mannosylglycerol (MGOH), and mannosyl-lactate (MGLac), 1,1-di-glycerol phosphate (DGP), ectoin, hydroxyectoin, and or derivatives or combinations thereof. The improved performance of the above mentioned techniques might be due to: a better state of preservation of the material to be immobilized, increasing the life expectancy of the material, and/or decreasing the storage and/or transport requirements, a more efficient and uniform deposition of the material on the support, more efficiency and/or specificity of hybridation of the marked material, all this originating an increase of the signal-to-noise ratio.
Type:
Application
Filed:
February 23, 2007
Publication date:
March 12, 2009
Applicants:
STAB VIDA, Investigacao e Servicos em Ciencias Biologicas, Lda, BITOP AG
Inventors:
Jorge Miguel Pereira De Oliveira Da Silva Santos, Catia Machado, Ana Catarina Varela Raposo, Stefano Volinia, Nicoletta Mascellani, Steven John Setford, Elisabeth Loose, Christopher David Maycock, Maria Rita Mendes Bordalo Ventura Centeno Lima, Pedro Lamosa Antonio, Isabel Sequeira Lopes, Helena Santos, Alcino Orfeu De Leao E Flores