Abstract: Disclosed and claimed is a novel inexpensive and efficient method for the early detection of HIV infection in babies. The method utilizes a unique IgA capture ELISA procedure for detection of HIV-specific antibodies.

Abstract: The subject invention concerns the production and novel use of human anti-HIV IgA antibodies to confer passive immunity to HIV when administered in vivo to a subject. The IgA antibodies of the subject invention are selectively transported to and secreted in the mucosal tissue of the subject. The IgA antibodies can confer protection from HIV infection at locations within the body where HIV penetration usually occurs.

Abstract: The subject invention pertains to methods of treating immunocompromised patients, such as individuals infected with HIV, that exhibit elevated levels of IgA relative to IgG. The use of IgA-binding compositions immobilized onto a support matrix to extracorporeally remove IgA molecules from a sample or biological fluid for therapeutic purposes is provided by the present invention. The subject invention further pertains to novel polypeptides which bind in a specific manner to human IgA. The polypeptides of the present invention comprise an IgA-binding region from an IgA-binding protein of Group B streptococcal bacteria.