Patents Assigned to BLAZE BIOSCIENCE, INC.
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Tumor homing and cell penetrating peptide-immuno-oncology agent complexes and methods of use thereof
Patent number: 11866466Abstract: Peptide-immuno-oncology agent complexes (“peptide-I/O complexes”) that can home, target, migrate to, are directed to, are retained by, accumulate in, penetrate, or bind to the tumor microenvironment, tumor tissues, or cells or compartments or cytosol of cells thereof, or any combination thereof, are disclosed. Additionally disclosed are peptide-I/O complexes that can cross the blood-brain barrier. Pharmaceutical compositions and uses for peptide-I/O complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an immuno-oncology agent (“I/O”) to the tumor microenvironment. Targeted compositions of the disclosure can deliver peptide-I/O complexes to target regions, tissues, structures or cells targeted by the peptide.Type: GrantFiled: December 18, 2018Date of Patent: January 9, 2024Assignee: BLAZE BIOSCIENCE, INC.Inventors: Natalie Winblade Nairn, Julia Novak, Kenneth Grabstein, Dennis Miller, Greg T. Hermanson, Scott R. Presnell, Mark Stroud -
Patent number: 11648290Abstract: Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or binds to the cartilage of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of a drug to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures or cells targeted by the peptide.Type: GrantFiled: June 21, 2021Date of Patent: May 16, 2023Assignees: FRED HUTCHINSON CANCER CENTER, BLAZE BIOSCIENCE, INC.Inventors: James Olson, Andrew David Strand, Emily June Girard, Roland Strong, Christopher Mehlin, Colin Correnti, Natalie Nairn
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Patent number: 11559580Abstract: Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.Type: GrantFiled: August 23, 2021Date of Patent: January 24, 2023Assignee: BLAZE BIOSCIENCE, INC.Inventors: Stacey J. Hansen, Claudia Jochheim, Dennis M. Miller, Natalie Winblade Nairn, Julia E. Novak, Mark R. Stroud, Valorie R. Wiss, Kelly Byrnes-Blake, Scott Presnell
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Patent number: 11331393Abstract: Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptide-active agent conjugates are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the kidney. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.Type: GrantFiled: June 14, 2018Date of Patent: May 17, 2022Assignee: Blaze Bioscience, Inc.Inventors: Julia E. Novak, Natalie Winblade Nairn, Dennis M. Miller
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Patent number: 11090358Abstract: Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or binds to the cartilage of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of a drug to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures or cells targeted by the peptide.Type: GrantFiled: September 9, 2016Date of Patent: August 17, 2021Assignees: FRED HUTCHINSON CANCER RESEARCH CENTER, BLAZE BIOSCIENCE, INC.Inventors: James Olson, Andrew David Strand, Emily June Girard, Roland Strong, Christopher Mehlin, Colin Correnti, Natalie Nairn
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Patent number: 11013814Abstract: Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.Type: GrantFiled: March 16, 2018Date of Patent: May 25, 2021Assignee: Blaze Bioscience, Inc.Inventors: Julia E. Novak, Natalie Winblade Nairn, Dennis M. Miller, Scott Presnell, Claudia Jochheim, Mark Stroud
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Publication number: 20210015350Abstract: Disclosed herein are imaging systems and methods for simultaneous near-infrared light and visible light imaging of a sample comprising: a detector to form a fluorescence image of the sample and a visible image of the sample; a light source configured to emit infrared light to induce fluorescence from the sample; and a plurality of optics arranged to direct the infrared light toward the sample and form the fluorescence image of the sample and the visible light image of the sample on the detector, wherein the infrared light is directed to the sample substantially coaxially with fluorescence light received from the sample in order to decrease shadows.Type: ApplicationFiled: March 28, 2019Publication date: January 21, 2021Applicant: BLAZE BIOSCIENCE, INC.Inventors: Pramod BUTTE, David KITTLE, Jeffrey PERRY