Patents Assigned to BLIRT S.A.
  • A NEW, NON-SPECIFIC THERMOLABILE NUCLEASE ACTIVE AT LOW TEMPERATURE, IN WIDE PH RANGE AND HIGH CONCENTRATION IN SALTS
    Publication number: 20230287369
    Abstract: The subject matter of this invention is a new thermolabile PPR nuclease or its enzymatically active fragment exhibiting high catalyst activity in difficult reaction conditions (particularly high concentrations of salts and other additives commonly used in the processes of the purification of proteins and viruses, low temperatures and wide range of pH), where the nuclease sequence is SEQ. 2 or a sequence that shares at least 40% of its identity. The subject matter of the invention is also the gene encoding PPR nuclease or its enzymatically active fragment; a particle of nucleic acid encoding the PPR nuclease or its enzymatically active fragment; expression plasmid including the sequence of the PPR encoding gene; recombinant strains of Escherichia coli JM109(DE3) pD454-PPR-AmpR and E. coli ArcticExpress (DE3) pD454-PPR-AmpR; the method of PPR nuclease protein production, application of PPR nuclease in processes of purification of recombinant proteins of significantly lower DNA content.
    Type: Application
    Filed: September 14, 2020
    Publication date: September 14, 2023
    Applicant: Blirt S.A.
    Inventors: Marcin Olszewski, Rafat Walkusz, Wioleta Lademan, Jan Balsewicz, Arkadiusz Popinigis, Dominik Zietkowski, Krzysztof Kur, Robert Brodzik
  • N-substituted second generation derivatives of antifungal antibiotic amphotericin B and methods of their preparation and application
    Patent number: 9745335
    Abstract: The invention provides semisynthetic N-substituted derivatives of the antifungal antibiotic Amphotericin B and water soluble salts and complexes, pharmaceutical compositions and plant and building treatment products comprising the derivatives and their use as antifungal antibiotics.
    Type: Grant
    Filed: June 14, 2013
    Date of Patent: August 29, 2017
    Assignee: BLIRT S.A.
    Inventors: Edward Borowski, Natalia Salewska, Joanna Boros-Majewska, Maria Milewska, Malgorzata Wysocka, Slawomir Milewski, Izabela Chabowska, Michal Sabisz
  • Semisynthetic derivatives of Nystatin A
    Patent number: 9447136
    Abstract: The invention provides semisynthetic derivatives of Nystatin A1, water soluble salts and complexes, pharmaceutical compositions and plant protection products comprising the derivatives and their use, as antifungal antibiotics (Formula 1a).
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: September 20, 2016
    Assignee: BLIRT S.A.
    Inventors: Edward Borowski, Natalia Salewska, Joanna Boros-Majewska, Maria Milewska, Malgorzata Wysocka, Slawomir Milewski, Andrzej Skladanowski, Adam Treder, Ewa Sadowska, Izabela Chabowska
  • SEMISYNTHETIC DERIVATIVES OF NYSTATIN A1
    Publication number: 20150045316
    Abstract: The invention provides semisynthetic derivatives of Nystatin A1, water soluble salts and complexes, pharmaceutical compositions and plant protection products comprising the derivatives and their use, as antifungal antibiotics (Formula 1a).
    Type: Application
    Filed: March 7, 2013
    Publication date: February 12, 2015
    Applicant: BLIRT S.A.
    Inventors: Edward Borowski, Natalia Salewska, Joanna Borosmajewska, Maria Milewska, Malgorzata Wysocka, Slawomir Milewski, Andrzej Skladanowski, Adam Treder, Ewa Owska, Izabela Lacka