Abstract: Embodiments disclosed herein provide for antibodies, including neutralizing antibodies, against Chikungunya virus, uses thereof, and methods of identifying antibodies, including neutralizing antibodies, against Chikungunya virus. In some embodiments, antibodies that binds to a CHIKV antigen, wherein the antigen is the CHIKV E1, E2, E3 protein, or any heterocomplex thereof are provided. In some embodiments, the antibody is an isolated antibody, a neutralizing antibody, a recombinant antibody, or any combination thereof. In some embodiments, the antibodies described herein bind to an epitope of E2 Domain A, E2 Domain B, or E1 Domain II of the CHIKV antigen. In some embodiments, the antigen is E2 protein.
Type:
Grant
Filed:
July 21, 2014
Date of Patent:
February 27, 2018
Assignees:
INTEGRAL MOLECULAR, INC., BLOOD SYSTEMS RESEARCH INSTITUTE
Inventors:
Benjamin Doranz, Kimberly-Anne Mattia, Kristen Kahle, Graham Simmons, Rachel Hua-Ning Fong, Soma Banik Banerjee