Patents Assigned to Bloodworks
  • Publication number: 20210088535
    Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.
    Type: Application
    Filed: September 28, 2020
    Publication date: March 25, 2021
    Applicants: University of Washington through its Center for Commercialization, Bloodworks
    Inventors: Daniel M. Ratner, Jill M. Johnsen, James T. Kirk, José A. López, Norman D. Brault, Shaoyi Jiang
  • Publication number: 20210063419
    Abstract: Compositions and methods for determining post-transfusion survival or toxicity of red blood cells and the suitability of red blood cell units for transfusion by measuring the levels of one or more compounds in a red blood cell sample are provided.
    Type: Application
    Filed: October 26, 2020
    Publication date: March 4, 2021
    Applicant: BLOODWORKS
    Inventor: James Charles Zimring
  • Publication number: 20210055313
    Abstract: Compositions and methods for determining post-transfusion survival or toxicity of red blood cells and the suitability of red blood cell units for transfusion by measuring the levels of one or more compounds in a red blood cell sample are provided.
    Type: Application
    Filed: November 9, 2020
    Publication date: February 25, 2021
    Applicant: BLOODWORKS
    Inventor: James Charles Zimring
  • Publication number: 20210041463
    Abstract: The current disclosure provides compositions, systems, and methods for detection and/or identification of antibodies. Also provided are compositions, systems, and methods that expedite and simplify processes to identify blood units that are clinically appropriate for transfusion into a recipient, and more generally to identify the presence of antibody(s) in blood that are specific for selected antigen(s). The systems and methods utilize genetically-modified (transgenic) non-target-organism red blood cells that express at least one antigen of the target organism species. This enables screening and identifying blood units faster, more consistently, at large scale, and/or with less dependence on human involvement.
    Type: Application
    Filed: February 1, 2019
    Publication date: February 11, 2021
    Applicant: BLOODWORKS
    Inventors: James Charles Zimring, Yanyun Wu
  • Publication number: 20200408785
    Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.
    Type: Application
    Filed: September 11, 2020
    Publication date: December 31, 2020
    Applicants: University of Washington through its Center for Commercialization, Bloodworks
    Inventors: Daniel M. Ratner, Jill M. Johnsen, James T. Kirk, José A. López, Norman D. Brault, Shaoyi Jiang
  • Patent number: 10830777
    Abstract: Compositions and methods for determining post-transfusion survival or toxicity of red blood cells and the suitability of red blood cell units for transfusion by measuring the levels of one or more compounds in a red blood cell sample are provided.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: November 10, 2020
    Assignee: Bloodworks
    Inventor: James Charles Zimring
  • Patent number: 10816557
    Abstract: Methods for testing a red blood cell (RBC) unit for release for transfusion into a subject are described. The methods allow management of the blood supply by assessing the viability of an RBC unit by its levels of dicarboxylic fatty acids (DFA). The methods include testing an RBC sample from an RBC unit for levels of DFA and discarding the RBC unit or releasing the RBC unit for transfusion based on the results.
    Type: Grant
    Filed: August 10, 2015
    Date of Patent: October 27, 2020
    Assignee: Bloodworks
    Inventor: James Charles Zimring
  • Patent number: 10806695
    Abstract: Compositions and methods are described for preventing or reducing protein loss due to protein aggregation, denaturation, and absorption to surfaces. Also described are compositions and methods for preventing or reducing the fouling or clogging of medical devices that come into contact with blood, such as catheters. Also described are methods to treat diseases caused by activation of the microvasculature.
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: October 20, 2020
    Assignee: BLOODWORKS
    Inventors: Dominic W. Chung, Jose Aron Lopez, Minhua Ling, Junmei Chen, Xiaoyun Fu
  • Publication number: 20200319199
    Abstract: Compositions and methods for determining the level of thiol and disulfide containing molecules in a sample are provided. The compositions and methods can be used to determine the level of oxidative stress in a subject with or without antioxidant treatment. Also provided are biomarkers of oxidative stress.
    Type: Application
    Filed: June 18, 2020
    Publication date: October 8, 2020
    Applicant: BLOODWORKS
    Inventors: Xiaoyun Fu, Shelby A. Cate, Jose Aron Lopez, Junmei Chen, Barbara A. Konkle
  • Patent number: 10785967
    Abstract: Provided is a transgenic mouse with modified glucose-6-phosphate dehydrogenase which can be used as a model and screening tool for various aspects of glucose-6-phosphate dehydrogenase deficiency.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: September 29, 2020
    Assignee: Bloodworks
    Inventor: James Charles Zimring
  • Patent number: 10786653
    Abstract: A catheter assembly with segmented or step-wise deployment stabilization system includes a base or handle, puncture needle extending from the handle, and a deployment mechanism or mechanisms to selectively extend from the distal end of the needle for first length a hollow stabilizing component and as a second step to a second further length a stabilizing guide wire element. The needle will gain sub-dermal access to the patient to the intended position for deployment of a catheter. Hollow stabilizing component provides for a first additional guide and support for a catheter sheath from the distal end of the needle. The stabilizing wire element provides additional length, guide and support for the catheter sheath. The hollow stabilizing component has some degree of flexibility as does the guide wire to minimize chance of damage to surrounding tissue.
    Type: Grant
    Filed: April 4, 2014
    Date of Patent: September 29, 2020
    Assignee: Bloodworks LLC
    Inventors: Joshua J. Galgano, Hanjun Kim, Jr., Robert J. Anderson
  • Patent number: 10705093
    Abstract: Compositions and methods for determining the level of thiol and disulfide containing molecules in a sample are provided. The compositions and methods can be used to determine the level of oxidative stress in a subject with or without antioxidant treatment. Also provided are biomarkers of oxidative stress.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: July 7, 2020
    Assignee: Bloodworks
    Inventors: Xiaoyun Fu, Shelby A. Cate, Jose Aron Lopez, Junmei Chen, Barbara A. Konkle
  • Patent number: 10677781
    Abstract: Compositions and methods for determining post-transfusion survival or toxicity of red blood cells and the suitability of red blood cell units for transfusion by measuring the levels of one or more markers in a red blood cell sample are provided.
    Type: Grant
    Filed: March 21, 2019
    Date of Patent: June 9, 2020
    Assignee: Bloodworks
    Inventors: James Charles Zimring, Karen S. de Wolski
  • Publication number: 20200158740
    Abstract: Compositions and methods for determining post-transfusion survival or toxicity of red blood cells and the suitability of red blood cell units for transfusion by measuring the levels of one or more markers in a red blood cell sample are provided.
    Type: Application
    Filed: January 23, 2020
    Publication date: May 21, 2020
    Applicant: Bloodworks
    Inventor: James Charles Zimring
  • Publication number: 20200138950
    Abstract: Methods and compositions for the prevention or reduction of platelet transfusion associated complications are provided. The subject methods include modifying donor whole blood or platelets prior to transfusion to prevent or reduce alloimmune platelet refractoriness.
    Type: Application
    Filed: May 30, 2017
    Publication date: May 7, 2020
    Applicant: BLOODWORKS
    Inventor: Sherrill J. Slichter
  • Publication number: 20200132700
    Abstract: Methods for predicting post-transfusion survival of red blood cells are provided herein. In some versions, the methods include measuring a level of lysophospholipids in a unit of red blood cells and predicting the post-transfusion survival of the red blood cells in the unit based on the measured level of lysophospholipids.
    Type: Application
    Filed: May 4, 2017
    Publication date: April 30, 2020
    Applicant: BLOODWORKS
    Inventors: James Charles Zimring, Xiaoyun Fu
  • Patent number: 10578627
    Abstract: Compositions and methods for determining post-transfusion survival or toxicity of red blood cells and the suitability of red blood cell units for transfusion by measuring the levels of one or more markers in a red blood cell sample are provided.
    Type: Grant
    Filed: May 29, 2019
    Date of Patent: March 3, 2020
    Assignee: Bloodworks
    Inventor: James Charles Zimring
  • Publication number: 20200060262
    Abstract: Methods to significantly reduce clot formation in cold-stored platelet samples are described. The methods include collecting platelet samples at defined yields and/or concentrations and allowing collected platelet samples to rest at room temperature without agitation for a period of time before being moved into cold storage.
    Type: Application
    Filed: August 23, 2019
    Publication date: February 27, 2020
    Applicant: BLOODWORKS
    Inventor: Moritz Stolla
  • Patent number: 10441531
    Abstract: Compositions and methods are described for preventing or reducing protein loss due to protein aggregation, denaturation, and adsorption to surfaces. Also described are compositions and methods for preventing or reducing the fouling or clogging of medical devices that come into contact with blood, such as catheters. Also described are methods to treat diseases caused by activation of the microvasculature.
    Type: Grant
    Filed: November 12, 2013
    Date of Patent: October 15, 2019
    Assignee: Bloodworks
    Inventors: Dominic Chung, Jose Aron Lopez, Minhua Ling, Junmei Chen, Xiaoyun Fu
  • Publication number: 20190285655
    Abstract: Compositions and methods for determining post-transfusion survival or toxicity of red blood cells and the suitability of red blood cell units for transfusion by measuring the levels of one or more markers in a red blood cell sample are provided.
    Type: Application
    Filed: May 29, 2019
    Publication date: September 19, 2019
    Applicant: Bloodworks
    Inventor: James Charles Zimring