Abstract: Provided herein are genetically engineered mammalian (e.g., human) cells that express one or more transgenes at a sustained expression level. Also provided are methods of making and using the cells.
Type:
Application
Filed:
October 9, 2020
Publication date:
February 22, 2024
Applicant:
BlueRock Therapeutics LP
Inventors:
Chew-Li SOH, Mark James TOMISHIMA, Dan Charles WILKINSON, Jr., Conor Brian McAULIFFE
Abstract: In some embodiments, a delivery device includes a device actuator and a cannula portion through which a therapeutic substance is ejected. The cannula portion includes an outer shaft, a needle that is configured to move through the outer shaft, and a plunger that is configured to move through the needle, forming a positive displacement arrangement.
Type:
Application
Filed:
April 26, 2023
Publication date:
August 17, 2023
Applicant:
BLUEROCK THERAPEUTICS LP
Inventors:
MATTHEW GARDNER MAHER, ANGEL LEONARDO GUERRERO PALACIO, PHILIPPE MARCHAND
Abstract: In some embodiments, a delivery device includes a device actuator and a cannula portion through which a therapeutic substance is ejected. The cannula portion includes an outer shaft, a needle that is configured to move through the outer shaft, and a plunger that is configured to move through the needle, forming a positive displacement arrangement.
Type:
Grant
Filed:
April 13, 2021
Date of Patent:
June 6, 2023
Assignee:
BLUEROCK THERAPEUTICS LP
Inventors:
Matthew Gardner Maher, Angel Leonardo Guerrero Palacio, Philippe Marchand
Abstract: Provided herein are enriched populations of ventricular compact cardiomyocytes and enriched populations of mature ventricular or atrial cardiomyocytes, as well as methods of generating the enriched cell populations and methods of using the enriched cell populations in regenerative cardiac cell therapies.
Type:
Application
Filed:
May 4, 2020
Publication date:
July 21, 2022
Applicants:
UNIVERSITY HEALTH NETWORK, BlueRock Therapeutics LP
Inventors:
Gordon M. Keller, Shunsuke Funakoshi, lan Fernandes, Donghe Yang, Dan Charles Wilkinson, Jr.
Abstract: A method for selecting a final model for detecting cells of interest in image datasets includes dividing a curated image dataset into a training set, a validation set, and a testing set where each image in the curated image dataset has been labeled as positive or negative for a cell of interest. The method trains each model of an ensemble of neural networks using the training and validation sets. Next, each model of the ensemble is tested using the testing set and the predictions of the ensemble are combined. The combined prediction is compared to the label and the method determines whether the combined prediction satisfies a pre-determined level of detection (LOD). If so, the method outputs the ensemble as a final ensemble. If not, the method modifies a hyperparameter of at least one of the models of the ensemble until the combined prediction satisfies the pre-determined LOD.
Type:
Application
Filed:
February 20, 2020
Publication date:
June 2, 2022
Applicant:
BlueRock Therapeutics LP
Inventors:
Dan Charles WILKINSON, Jr., Benjamin Adam BURNETT
Abstract: In some embodiments, a delivery device includes a device actuator and a cannula portion through which a therapeutic substance is ejected. The cannula portion includes an outer shaft, a needle that is configured to move through the outer shaft, and a plunger that is configured to move through the needle, forming a positive displacement arrangement.
Type:
Application
Filed:
April 13, 2021
Publication date:
October 14, 2021
Applicant:
BLUEROCK THERAPEUTICS LP
Inventors:
MATTHEW GARDNER MAHER, ANGEL LEONARDO GUERRERO PALACIO, PHILIPPE MARCHAND