Abstract: CDDO-compounds in combination with other chemotherapeutic agents induce and potentiate cytotoxicity and apoptosis in cancer cell. One class of chemotherapeutic agents include retinoids. Cancer therapies based on these combination therapies are provided. Also provided are methods to treat graft versus host diseases using the CDDO compounds.
Type:
Application
Filed:
November 28, 2001
Publication date:
June 26, 2003
Applicant:
Board of
Inventors:
Marina Konopleva, Michael Andreeff, Michael B. Sporn