Abstract: The high intensity natural sweetener monatin, an .alpha.-amino acid (1) is synthesized from readily available starting materials. Regiospecific ring opening of epoxide (9) with indole magnesium bromide yields lactone (11). Amination of (11) followed by saponification yields Monatin.

Abstract: A self-activated acaricide applicator for killing ticks on large mammals. The applicator is self-activated by motion and heat detection when the mammal moves to investigate an attractant canister. This results in the discharge of an atomized acaricide onto the mammal.

Abstract: A discriminant neural network and a method of training the network are disclosed. The network includes a set of hidden nodes having associated weights, and the number of hidden nodes is minimized by the training method of the invention. The training method includes the steps of 1) loading a training data set and assigning it to a residual data set, 2) computing a vector associated with a first hidden node using the residual data set, 3) projecting training data onto a hyperplane associated with said first hidden node, 4) determining the number and locations of hard-limiter thresholds associated with the first node, and 5) repeating the above for successive hidden nodes after removing satisfied subsets from the training data until all partitioned regions of the input data space are satisfied.

Abstract: The present invention relates to a composition, and method of use, of an octahydrobenzo?f!quinoline-based compound represented by structural formula (I). In this formula, R.sup.1 is --OH or --OCH.sub.3 and R.sup.2 is --H, --OH or --OCH.sub.3. In addition, R.sup.3 is a C1 to C2 saturated or unsaturated, alkyl group. Furthermore, R.sup.4 is an aryl group, wherein examples of suitable aryl groups, as defined herein, include phenyl and thienyl groups. The method of this invention relates to the use of the claimed compositions to treat psychotic disorders, to treat Parkinson's disease, or to sedate a mammal by administering an effective amount of a claimed composition.

Abstract: Antibodies against Ins(1,4,5)P.sub.3 were raised by immunizing rabbits with two types of IP.sub.3 -BSA conjugates which were synthesized by covalently coupling Ins(1,4,5)P.sub.3 to the carrier protein via alkyl linkages. The anti-Ins(1,4,5)P.sub.3 antibodies were detected by an ELISA where Ins(1,4,5)P.sub.3 was covalently attached to a microplate well surface. Both antiserum preparations showed specific binding with Ins(1,4,5)P.sub.3. The specificity of these antibodies was enhanced by affinity purification for the antiserum through Ins(1,4,5)P.sub.3 -agarose chromatography. The affinity-purified antibodies have IC.sub.50 values of 12 nM and 73OnM for Ins(1,4,5)P.sub.3 and Ins(1,3,4,5)P.sub.4, respectively. These antibodies showed many properties similar to those of biologically relevant receptors for Ins(1,4,5)P.sub.3.

Abstract: Adherent cell lines are grown on cover slips. The cover slips are placed in a culture media containing fluctuating concentrations of drugs for the purpose of testing simulated drug dosage regimens for use in the treatment of human infection. The cover slips are removed and the cells are harvested and processed for viable bacterial numbers of viral DNA over time.

Abstract: A process for the production of a compound of the formula: ##STR1## wherein R.sub.1 is hydrogen, alkyl, C.sub.1 -C.sub.16 substituted alkyl, aryl, substituted aryl, aralkyl, substituted aralkyls, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cyano, carboxy, carboxy esters, carboxamido, or N-mono substituted and N,N-disubstituted carboxamido with alkyl, aralkyl or aryl groups; R.sub.2 is hydrogen, alkyl C.sub.1 -C.sub.16 substituted alkyl, aryl, substituted aryl, aralkyl, substituted aralkyls, alkenyl, substituted alkenyl, alkynyl or substituted alkynyl; R.sub.3 is alkyl C.sub.2 -C.sub.6, branched alkyl, aryl C.sub.2 -C.sub.6 or substituted aryl and R.sub.4 is halogen or H.A condensation reaction is effected between compounds of the formulae: ##STR2## to form a novel compound of the formula: ##STR3## Compound (2) is acylated with a compound of the formula:R.sub.

Abstract: A disk storage architecture called DCD, Disk Caching Disk, for optimizing I/O performance. The DCD uses a small log disk, referred to as cache-disk, in the range of tens of MB as a secondary disk cache to optimize write performance. While the cache-disk and the normal data disk have the same physical properties, the access speed of the former differs dramatically from the latter because of different data units and different ways in which data are accessed. The objective is to exploit this speed difference by using the log disk as a cache to build a reliable and smooth disk hierarchy.

Abstract: This invention disclosed (2S,3R)-3(6-aminopurin-9-yl) aralkan-2-ols, a novel class of adenine derivatives (also called 9-aralkyladenines, ARADS), which have been shown to inhibit the enzyme adenosine deaminase at therapeutically useful levels. The relevant inhibitory constant (K.sub.i) values are in the range of 10.sup.-7 -10.sup.-10 M. These compounds with potencies in this range can reversibly inhibit ADA in an effective manner, without permanently deactivating the enzyme. ADA inhibitors that have similar biological profiles have been shown to be of therapeutic value when used to protect heart muscle against ischemic damage.

Abstract: Enantiomerically pure glycerol derivatives, e.g. S-1,2-O-isopropylidene, S-1,2-O-benzylidene, and R-1,2-O-dibenzyl glycerol, have been prepared from 1,2R-O-protected erythritols in high yields. The latter compounds are easily obtained from erythorbic acid and are useful building blocks in the synthesis of a host of optically active compounds having biological activity.

Abstract: Sphingolipids are involved in the structure of biological membranes. There is a link between sphingolipids and signal transduction. The invention relates to the stereospecific syntheses of dihidrosphingosines using certain chiral epoxides.

Abstract: The invention discloses monoclonal antibodies which bind specifically to Type II collagen, but not to its peptides, or vice versa. Also disclosed are the methods of preparing hybridomas for production of these antibodies; the assays which utilize these antibodies to detect or quantify Type II collagen and/or its peptides in a solution (e.g., body fluid, culture medium, and tissue extract); and assay kits containing these antibodies.

Abstract: Two types of structural analogues of D-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P.sub.4 ] are prepared by a chemo-enzymatic route. These 6-O-substituted analogues retain the biological activity of Ins(1,4,5)P.sub.3 and are able to elicit Ca.sup.2+ release from porcine brain microsomes. Moreover, these analogues allow the preparation of Ins(1,4,5)P.sub.3 -based immunogens and affinity matrix which are successfully applied to the preparation and purification of antibodies against Ins(1,4,5)P.sub.3. These antibodies display discriminative affinity toward Ins(1,4,5)P.sub.3, and provide a useful tool to study intracellular Ca.sup.2+ mobilization.

Abstract: A cache memory system for use during vector processing in a processor. The processor contains a central processing unit (CPU) and a main memory. The system includes a vector cache memory, a first address register, a main memory address calculation unit, and a cache address calculation unit. The first register stores a first address associated with an instruction executed by the CPU. The main memory address calculation unit is coupled to the first address register for calculating a second address utilizing the first address and vector stride data associated with said executed instruction. The second address is utilized to access the main memory. The cache address calculation unit is coupled to both the first address register and the main memory address calculation unit for calculating the third address utilizing portions of the first address and portions of the second address. The third address is utilized to access the vector cache memory.

Abstract: A system for coulometric TCO.sub.2 analysis wherein a sample bottle is pressurized by a head space gas having a CO.sub.2 composition which approximates the dissolved CO.sub.2 concentration in the sample. The head space gas transfers to sample to a pipette. The sample is then transferred to a stripper where the sample is degassed. Two carrier gas lines flush the stripper and transfer the CO.sub.2 to a coulometer.

Abstract: A computer modeling approach is taken to delineate the structural requirements of substrate molecules for biocatalytic turnover and enantioselective discrimination. This leads to an efficient enzymatic preparation of optically active propranolol. The acyl-sustituents on the alcohol and the secondary amine of propranolol play crucial roles in controlling the catalysis and enantiospecificity, respectively, of the enzymatic hydrolysis.

Abstract: A zero crossing based spectrum analyzer, a method that samples zero crossings of a signal waveform containing only real zeros and uses this information to determine the discrete Fourier Transform coefficients, is disclosed. A band-limited signal represented by real and complex zeros is converted by invertible techniques to a signal that contains only real (physical) zeros. This converted signal is applied as the input signal to the zero crossing based spectrum analyzer.

Abstract: Multigram quantities of Ins(1,4,5) P.sub.3, Ins(1,3,4) P.sub.3, and Ins(1,3,4,5)P.sub.4 are prepared in their enantiomerically pure forms from the two enantiomers of 1,2:5,6-di-O-cyclohexylidene myo-inositol. Also, a facile enzymatic preparation is also described of these chiral precursors through enantiospecific deacylation of the corresponding racemic esters is disclosed.

Abstract: Electrochromic material, i.e. polyaniline, is polymerized in situ in a polymeric electrolyte to form an electrochromic/polyelectrolyte mixture. The mixture is coated as a film on electrochromic material. A film of electrolyte is placed in ion transfer relationship with the electrochromic/polyelectrolyte film. This electrochromic/polyaniline/polyelectrolyte film greatly increases the ion transfer between the electrochromic film and the electrolytic film by imposing a region of molecularly mixed electrochromic material and electrolyte.

Abstract: A signal processing apparatus and method for iteratively determining the inverse Arithmetic Fourier Transform (AFT) of an input signal by converting the input signal, which represents Fourier coefficients of a function that varies in relation to time, space, or other independent variable, into a set of output signals representing the values of a Fourier series associated with the input signal. The signal processing apparatus and method utilize a process in which a data set of samples is used to iteratively compute a set of frequency samples, wherein each computational iteration utilizes error information which is calculated between the initial data and data synthesized using the AFT. The iterative computations converge and provide AFT values at the Farey-fraction arguments which are consistent with values given by a zero-padded Discrete Fourier Transform (DFT), thus obtaining dense frequency domain samples without interpolation or zero-padding.