Patents Assigned to Board of Regents
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Patent number: 12265089Abstract: A method is provided for distinguishing between and/or diagnosing Parkinson's disease (PD) or multiple system atrophy (MSA) in a subject who is exhibiting symptoms associated with both PD and MSA. The method comprises: (A) contacting a biological sample obtained from the subject and comprising soluble, misfolded alpha-synuclein (?S) protein with a pre-incubation mixture comprising a monomeric ?S substrate and an indicator to form an incubation mixture; (B) conducting an incubation cycle two or more times on the incubation mixture to form misfolded ?S aggregates; (C) subjecting the incubation mixture to excitation and detecting via indicator fluorescence emission the misfolded ?S aggregates; and (D) diagnosing the subject has having PD or MSA depending on the fluorescence emission intensity. In some aspects, the incubation cycles are conducted in the presence of a bead.Type: GrantFiled: January 21, 2021Date of Patent: April 1, 2025Assignees: Board of Regents of the University of Texas System, Amprion, Inc.Inventors: Claudio Soto Jara, Mohammad Shahnawaz, Luis Concha
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Patent number: 12266936Abstract: A subspace-based approach to synchrophasor estimation is provided. Embodiments described herein provide two improvements to subspace-based phasor measurement unit (PMU) algorithms based on estimation of signal parameters via rotational invariance techniques (ESPRIT) frequency estimation. The first is a dynamic, real-time thresholding method to determine the size of the signal subspace. This allows for accurate ESPRIT-based frequency estimates of the nominal system frequency as well as the frequencies of any out-of-band interference or harmonic frequencies. Since other frequencies are included in the least squares (LS) estimate, the interference from frequencies other than nominal can be excluded. This results in a near flat estimation error over changes in a) nominal system frequency, b) harmonic distortion, and c) out-of-band interference. Second, the computational burden of ESPRIT is reduced and the proposed algorithm runs in real time on resource-constrained platforms.Type: GrantFiled: December 23, 2021Date of Patent: April 1, 2025Assignees: Arizona Board of Regents on behalf of Arizona State University, The United States of America as Represented by the Secretary of the ArmyInventors: Zachary Drummond, Kevin Claytor
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Patent number: 12264305Abstract: A method and device for isolating a migratory cell population from a mixed population of migratory cells and non-migratory cells is described herein. The method comprises placing the mixed population of migratory cells and non-migratory cells in contact with a device having one or more microchannels; and isolating the migratory cell population within the microchannels following an incubation period, wherein the one or more microchannels have an average size in a proliferation direction of the migratory cells that is less than a minimum proliferation space of the migratory cells along the proliferation direction.Type: GrantFiled: September 18, 2019Date of Patent: April 1, 2025Assignees: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMAInventors: Young-tae Kim, Loan Bui, James Battiste, Xue Cai, Michael Sughrue
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Patent number: 12264655Abstract: Previous electrochemically-powered yarn muscles cannot be usefully operated between extreme negative and extreme positive potentials, since strokes during electron injection and during hole injection partially cancel because they are in the same direction. Unipolar-stroke carbon nanotube yarn muscles are described in which muscle strokes are additive between extreme negative and extreme positive potentials, and stroke increases with potential scan rate. These electrochemical artificial muscles include an electrically conducting twisted or coiled yarn and a material that dramatically shifts the potential of zero charge of the electrochemically actuated yarn.Type: GrantFiled: February 3, 2020Date of Patent: April 1, 2025Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Hetao Chu, Jinsong Leng, Ray H. Baughman, Xinghao Hu, Na Li, Carter S. Haines, Shaoli Fang, Zhong Wang, Jiuke Mu
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Patent number: 12263011Abstract: Provided herein are, inter alia, methods for identifying subjects suffering from depression that will respond to treatment with an antidepressant.Type: GrantFiled: October 15, 2019Date of Patent: April 1, 2025Assignees: Department of Veternas Affairs, Board of Regents, The University of Texas SystemInventors: Amit Etkin, Madhukar Trivedi, Wei Wu
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Patent number: 12265223Abstract: Eye-tracked head-mounted displays are provide which, in one aspect, may utilize the same optics for eyetracking and image viewing, with a selected portion of the optics used for an eyetracking optical path and a selected portion of the display optics used for an image viewing optical path.Type: GrantFiled: October 29, 2021Date of Patent: April 1, 2025Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, AUGMENTED VISION INC.Inventors: Hong Hua, Chunyu Gao
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Patent number: 12263462Abstract: A material for separating and pumping oxygen is disclosed. The material is a zeolite doped with a chemical element having an electron density of between 30 kJ/mol and 150 kJ/mol. The material is configured for controllable oxygen desorption between 150° C. and 300° C. and pumping the released oxygen into an area having an ambient pressure of less than 100 pascals.Type: GrantFiled: August 6, 2021Date of Patent: April 1, 2025Assignee: Arizona Board of Regents on Behalf of Arizona State UniversityInventors: Steven Wilson, Christopher Muhich, Ellen B. Stechel, Ivan Ermanoski
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Patent number: 12262962Abstract: Systems and methods for providing orientation data to a user during a medical procedure performed on a subject are provided. The system can include a medical device, an electrical component and a display device. The medical device is configured to engage a portion the subject and includes a handle. The electrical component is disposed within the handle and is configured to generate data related to an orientation of the medical device during the medical procedure. The display device is physically separate from the medical device and in communication the electrical component. The display device also includes a processor configured to receive and process the data related to the orientation of the medical device, and display information related to the orientation of the medical device to the user based on the data.Type: GrantFiled: February 27, 2018Date of Patent: April 1, 2025Assignees: Dignity Health, Arizona Board of Regents on Behalf of Arizona State UniversityInventors: Brian Kelly, Anna Newcomb, William Langenbach, Kirsten Jefferys, Luis Manuel Tumialan, James Abbas
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Patent number: 12263243Abstract: The present invention includes compositions and methods for treating and delivering medicinal formulations using an inhaler. The composition includes a space filled flocculated suspension having one or more flocculated particles of one or more active agents and a hydrofluoroalkane propellant. A portion of the one or more flocculated particles is templated by the formation of hydrofluoroalkane droplets upon atomization and the templated floc compacts upon the evaporation of the hydrofluoroalkane propellant to form a porous particle for deep lung delivery.Type: GrantFiled: February 13, 2009Date of Patent: April 1, 2025Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Keith P. Johnston, Joshua Engstrom, Jasmine Tam, Robert O. Williams, III, Alan B. Watts
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Patent number: 12263156Abstract: The present invention discloses methods of inhibiting biofilm formation, increasing bacteriocidal activity within a biofilm, treating bacteria within a biofilm, or remediating a biofilm in or on a subject, comprising administering to the subject an effective amount of a compound according to Formula I: wherein R1-5 are defined herein.Type: GrantFiled: October 15, 2021Date of Patent: April 1, 2025Assignees: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, The Board of Regents for Oklahoma State University, University of KansasInventors: Mario Rivera, Huili Yao, Richard A. Bunce, Baskar Nammalwar, Krishna Kumar Gnanasekaran, Kate Eshelman, Achala N. D. Punchi Hewage, Scott Lovell, Anabel Soldano
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Patent number: 12263165Abstract: The present disclosure provides compounds, their pharmaceutical compositions, and methods of their use for treating mesenchymally-derived or mesenchymally-transformed cancers, such as breast cancers and sarcomas, and for treating diseases or disorders that are characterized by the expression of vimentin.Type: GrantFiled: July 11, 2023Date of Patent: April 1, 2025Assignees: The Scripps Research Institute, Board of Regents, The University of Texas SystemInventors: Luke L. Lairson, Michael J. Bollong, Peter G. Schultz, Sendurai A. Mani
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Patent number: 12264318Abstract: Modified ribosomes that were selected using a dipeptidyl-puromycin aminonucleoside are used to mediate site-specific incorporation of one or more peptides and peptidomimetics into protein in a cell free translation system. In addition, new fluorescent dipeptidomimetics have been synthesized and incorporated into proteins, as well as modified proteins containing one or more non-naturally occurring dipeptides.Type: GrantFiled: July 19, 2022Date of Patent: April 1, 2025Assignee: Arizona Board of Regents on behalf of Arizona State UniversityInventors: Sidney Hecht, Larisa (Liza) Dedkova, Rumit Maini, Sandipan Roy Chowdhury, Rakesh Paul
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Patent number: 12264263Abstract: Methods and formulations for use of phase change materials (PCMs) as coatings or integrated with building materials are disclosed. A formulation comprises an amount of phase change material, for example a mass fraction of about 0.01 to about 0.50. The PCM materials may be applied as a surface treatment such as paint, for example in order to provide improved thermal regulation to a building or a portion thereof.Type: GrantFiled: July 9, 2021Date of Patent: April 1, 2025Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventors: Matthew Aguayo, Aashay Arora, Narayanan Neithalath
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Patent number: 12263250Abstract: Nanofiber segments comprising polymeric electrospun nanofibers are provided as well as methods of use thereof and methods of making.Type: GrantFiled: April 23, 2019Date of Patent: April 1, 2025Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKAInventors: Jingwei Xie, Sunil Kumar Boda
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Publication number: 20250099223Abstract: A vascular access device and assembly characterized by a tubular access graft having at least one angled distal flange that forms a non-circular distal opening to the tubular access graft, with the angled distal flange having a reinforcement structure that expands the flange and abuts a luminal wall surface of a blood vessel. Optionally, an axial compression ring or cuff may be provided that concentrically engages the tubular access graft and is translatable into a position that abuts an abluminal wall surface of the blood vessel. Also optionally, the device and assembly may include an annular ring with a plurality of axially projecting tines arrayed about a circumference of the annular ring, the annular ring being adapted to evert upon engagement with vascular tissue and creation of an access open by either an arteriotomy or a venotomy. The plurality of tines are configured to engage vascular tissue and then rotate to a different axial orientation to evert the periphery of the access site.Type: ApplicationFiled: September 19, 2024Publication date: March 27, 2025Applicants: Connex Biomedical, Inc., The Board of Regents of University of Colorado, a body corporateInventors: Max Bannister Mitchell, Jeremy H. Morgan, Jeffrey N. Steinmetz
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Publication number: 20250101079Abstract: The present disclosure provides methods for generating MAGE-B2 specific T cells and compositions comprising engineered MAGE-B2-specific T cell receptors. Further provided are methods of treating cancer comprising administering the MAGE-B2-specific T cells.Type: ApplicationFiled: December 9, 2024Publication date: March 27, 2025Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Cassian YEE, Ke PAN
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Patent number: 12257261Abstract: Provided is a method of making a preliposomal Annamycin lyophilizate, the composition made by the method, and the use of the composition made thereby in the treatment of cancer.Type: GrantFiled: December 17, 2021Date of Patent: March 25, 2025Assignees: Board of Regents, The University of Texas System, Moleculin Biotech, Inc.Inventors: Donald Picker, Waldemar Priebe
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Patent number: 12257302Abstract: The disclosure relates to vaccination compositions, for example, against human papillomavirus, Zika virus, and flu virus. The disclosure also relates to vectors for producing the virus-like particles and immune complex platforms of the vaccination compositions.Type: GrantFiled: November 8, 2023Date of Patent: March 25, 2025Assignee: Arizona Board of Regents on Behalf of Arizona State UniversityInventors: Hugh Mason, Andrew Diamos, Mary Pardhe, Brandon Favre
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Patent number: 12258370Abstract: The present disclosure relates to Betulastatin compounds, pharmaceutical compositions and kits comprising such compounds, and methods for using such compounds or pharmaceutical compositions.Type: GrantFiled: February 8, 2023Date of Patent: March 25, 2025Assignee: Arizona Board of Regents on behalf of Arizona State UniversityInventors: George R. Pettit, Noeleen Melody
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Patent number: 12258337Abstract: Disclosed herein are novel cycloalka[b]heteroaryl compounds having CX3CR1/fractalkine receptor (CX3CR1) agonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment or prophylaxis of diseases associated with CX3CR1 receptor activity in animals, in particular humans.Type: GrantFiled: September 19, 2023Date of Patent: March 25, 2025Assignees: Board of Regents, The University of Texas System, Golgi Neurosciences S.R.L.Inventors: Paolo Pevarello, William J. Ray, Mary Hamby, Yaima Luzardo Lightfoot, Philip Jones, Russell Thomas, Chiara Liberati, Domenica Torino, Valentina Cusano, Francesco Piscitelli, Ali Munaim Yousif, Silvia Bovolenta