Patents Assigned to Board of Regents
  • Publication number: 20250114313
    Abstract: The present disclosure describes an oligobenzamide-based peptidomimetic agent with potent antiproliferative activity against triple negative breast cancer (TNBC), including TNBC cells representing all the known molecular subtypes. Lysosomal acid lipase A (LIPA) was identified as important for this agent's activity with the ER localization, not the lysosomal lipase function, of LIPA being critical. This agent can also block the growth in vitro and in vivo of multiple cancer types that have high basal level of ER stress and LIPA expression, including estrogen receptor-positive breast, pancreatic, glioblastoma and ovarian cancers. Thus, the inventors propose a new targeted strategy for TNBC and other rapidly proliferating cancers.
    Type: Application
    Filed: February 10, 2023
    Publication date: April 10, 2025
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Ganesh RAJ, Ratna VADLAMUDI, Jung-Mo AHN, Xihui LIU
  • Patent number: 12269369
    Abstract: Provided, in one aspect, is a battery pack. The battery pack, in accordance with this aspect, includes an enclosure. The battery pack, in accordance with this aspect, further includes an intake port attached to a first section of the enclosure, the intake port coupleable to a source of cooling fluid, a first exhaust port attached to a third section of the enclosure and a second exhaust port coupled to a fourth section of the enclosure. The battery pack of this aspect further includes a first set of battery cells located within the enclosure in the first and third sections, the first set of battery cells separated by one or more first fluid passageways and a second set of battery cells located within the enclosure in a second and the fourth sections, the second set of battery cells separated by one or more second fluid passageways.
    Type: Grant
    Filed: December 13, 2023
    Date of Patent: April 8, 2025
    Assignee: Board of Regents, The University of Texas System
    Inventors: Jie Zhang, Yuanzhi Liu
  • Patent number: 12268827
    Abstract: The present application includes a sheath that is suitable for use in a variety of medical procedures. In one or more implementations, the sheath includes a shunt member, and a curvable portion. The curvable portion may be configured in various orientations to facilitate an intervention, such as a hemodialysis intervention, or the like, by an operator. The curvable portion may be configured to bend between a substantially straight configuration and a curved configuration. In implementations, the sheath may be configured to have detachable and/or interchangeable components (e.g., shunt member, curvable portion, etc.).
    Type: Grant
    Filed: August 22, 2022
    Date of Patent: April 8, 2025
    Assignee: Board of Regents of the University of Nebraska
    Inventor: Gregory Gordon
  • Patent number: 12268527
    Abstract: The present disclosure presents arrhythmia analysis systems and methods. One such method comprises processing an acquired ECG waveform signal to remove noise artifacts and form a denoised ECG waveform signal; processing the denoised ECG waveform signal to remove low quality segments and form a high quality ECG waveform signal; analyzing the high quality ECG waveform to detect a presence of a beat-independent ventricular arrhythmia; processing the denoised ECG signal to extract beat (R-peak) locations corresponding to QRS complexes from the denoised ECG signal; analyzing the denoised ECG signal to detect a presence of a beat-dependent ventricular arrhythmia based on the extracted beat (R-peak) locations; analyzing the denoised ECG signal to detect a presence of one or more supraventricular arrhythmias based on the extracted beat locations of the ECG signal; and outputting a report containing one or more arrhythmias detected by the analyzing steps. Other methods/systems are also provided.
    Type: Grant
    Filed: July 20, 2021
    Date of Patent: April 8, 2025
    Assignee: Board of Regents, The University of Texas System
    Inventors: Vignesh Kalidas, Lakshman S. Tamil
  • Patent number: 12272265
    Abstract: Processing circuitry of a learning platform may be configured to maintain a graph database describing student learners. Processing circuitry may obtain new student learner data and load the data into the graph database. Processing circuitry may receive an engagement or interaction from the new student learner and responsively extract new learnings about the new student learner which are loaded into the graph database. Processing circuitry may receive an inquiry from the new student learner and in response, extract the new student learner data and the new learnings from the graph database and contextualize, using a large language model, a learning unit from the educational content provided by the learning platform as a response to the inquiry using the new student learner data and the new learnings. Processing circuitry may further return the learning unit contextualized by the large language model to the new student learner.
    Type: Grant
    Filed: May 10, 2024
    Date of Patent: April 8, 2025
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventor: Mark Naufel
  • Publication number: 20250111960
    Abstract: Sensors employing elastomers enhanced with electrically conductive 2D nanoparticles are provided. The nanoparticles are formed by applying shear to layered materials present in elastomer precursors (e.g., elastomeric monomer(s) and/or curing agent(s)). Subsequent exfoliation of the layers occurs directly within the precursor and/or curing agent. The cured elastomer nanocomposites can be employed for electrochemical sensing, flexible touchpads, pressure sensors, and wireless sensors, amongst other applications.
    Type: Application
    Filed: September 6, 2024
    Publication date: April 3, 2025
    Applicants: Rutgers, The State University of New Jersey, The Board of Regents of The University of Texas System
    Inventors: Jennifer K. Lynch-Branzoi, Ali Ashraf, Ashiqur Rahman, Nazmul Islam
  • Publication number: 20250109443
    Abstract: The present disclosure comprises a method of detecting circular tumor cells and methods of detecting, evaluating, or staging cancer in a patient, as well as a method of monitoring treatment of cancer in a patient using the claimed method. In other embodiments, the method provides for directed to a method of determining the level of circulating tumor cells (CTCs) in a sample having blood cells from a patient by contacting a sample having blood cells from a patient.
    Type: Application
    Filed: September 3, 2024
    Publication date: April 3, 2025
    Applicant: Board of Regents, The University of Texas System
    Inventor: Ruth KATZ
  • Patent number: 12262962
    Abstract: Systems and methods for providing orientation data to a user during a medical procedure performed on a subject are provided. The system can include a medical device, an electrical component and a display device. The medical device is configured to engage a portion the subject and includes a handle. The electrical component is disposed within the handle and is configured to generate data related to an orientation of the medical device during the medical procedure. The display device is physically separate from the medical device and in communication the electrical component. The display device also includes a processor configured to receive and process the data related to the orientation of the medical device, and display information related to the orientation of the medical device to the user based on the data.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: April 1, 2025
    Assignees: Dignity Health, Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Brian Kelly, Anna Newcomb, William Langenbach, Kirsten Jefferys, Luis Manuel Tumialan, James Abbas
  • Patent number: 12263011
    Abstract: Provided herein are, inter alia, methods for identifying subjects suffering from depression that will respond to treatment with an antidepressant.
    Type: Grant
    Filed: October 15, 2019
    Date of Patent: April 1, 2025
    Assignees: Department of Veternas Affairs, Board of Regents, The University of Texas System
    Inventors: Amit Etkin, Madhukar Trivedi, Wei Wu
  • Patent number: 12263156
    Abstract: The present invention discloses methods of inhibiting biofilm formation, increasing bacteriocidal activity within a biofilm, treating bacteria within a biofilm, or remediating a biofilm in or on a subject, comprising administering to the subject an effective amount of a compound according to Formula I: wherein R1-5 are defined herein.
    Type: Grant
    Filed: October 15, 2021
    Date of Patent: April 1, 2025
    Assignees: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, The Board of Regents for Oklahoma State University, University of Kansas
    Inventors: Mario Rivera, Huili Yao, Richard A. Bunce, Baskar Nammalwar, Krishna Kumar Gnanasekaran, Kate Eshelman, Achala N. D. Punchi Hewage, Scott Lovell, Anabel Soldano
  • Patent number: 12263462
    Abstract: A material for separating and pumping oxygen is disclosed. The material is a zeolite doped with a chemical element having an electron density of between 30 kJ/mol and 150 kJ/mol. The material is configured for controllable oxygen desorption between 150° C. and 300° C. and pumping the released oxygen into an area having an ambient pressure of less than 100 pascals.
    Type: Grant
    Filed: August 6, 2021
    Date of Patent: April 1, 2025
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Steven Wilson, Christopher Muhich, Ellen B. Stechel, Ivan Ermanoski
  • Patent number: 12263250
    Abstract: Nanofiber segments comprising polymeric electrospun nanofibers are provided as well as methods of use thereof and methods of making.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: April 1, 2025
    Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Jingwei Xie, Sunil Kumar Boda
  • Patent number: 12264305
    Abstract: A method and device for isolating a migratory cell population from a mixed population of migratory cells and non-migratory cells is described herein. The method comprises placing the mixed population of migratory cells and non-migratory cells in contact with a device having one or more microchannels; and isolating the migratory cell population within the microchannels following an incubation period, wherein the one or more microchannels have an average size in a proliferation direction of the migratory cells that is less than a minimum proliferation space of the migratory cells along the proliferation direction.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: April 1, 2025
    Assignees: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA
    Inventors: Young-tae Kim, Loan Bui, James Battiste, Xue Cai, Michael Sughrue
  • Patent number: 12263165
    Abstract: The present disclosure provides compounds, their pharmaceutical compositions, and methods of their use for treating mesenchymally-derived or mesenchymally-transformed cancers, such as breast cancers and sarcomas, and for treating diseases or disorders that are characterized by the expression of vimentin.
    Type: Grant
    Filed: July 11, 2023
    Date of Patent: April 1, 2025
    Assignees: The Scripps Research Institute, Board of Regents, The University of Texas System
    Inventors: Luke L. Lairson, Michael J. Bollong, Peter G. Schultz, Sendurai A. Mani
  • Patent number: 12265089
    Abstract: A method is provided for distinguishing between and/or diagnosing Parkinson's disease (PD) or multiple system atrophy (MSA) in a subject who is exhibiting symptoms associated with both PD and MSA. The method comprises: (A) contacting a biological sample obtained from the subject and comprising soluble, misfolded alpha-synuclein (?S) protein with a pre-incubation mixture comprising a monomeric ?S substrate and an indicator to form an incubation mixture; (B) conducting an incubation cycle two or more times on the incubation mixture to form misfolded ?S aggregates; (C) subjecting the incubation mixture to excitation and detecting via indicator fluorescence emission the misfolded ?S aggregates; and (D) diagnosing the subject has having PD or MSA depending on the fluorescence emission intensity. In some aspects, the incubation cycles are conducted in the presence of a bead.
    Type: Grant
    Filed: January 21, 2021
    Date of Patent: April 1, 2025
    Assignees: Board of Regents of the University of Texas System, Amprion, Inc.
    Inventors: Claudio Soto Jara, Mohammad Shahnawaz, Luis Concha
  • Patent number: 12263243
    Abstract: The present invention includes compositions and methods for treating and delivering medicinal formulations using an inhaler. The composition includes a space filled flocculated suspension having one or more flocculated particles of one or more active agents and a hydrofluoroalkane propellant. A portion of the one or more flocculated particles is templated by the formation of hydrofluoroalkane droplets upon atomization and the templated floc compacts upon the evaporation of the hydrofluoroalkane propellant to form a porous particle for deep lung delivery.
    Type: Grant
    Filed: February 13, 2009
    Date of Patent: April 1, 2025
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Keith P. Johnston, Joshua Engstrom, Jasmine Tam, Robert O. Williams, III, Alan B. Watts
  • Patent number: 12264655
    Abstract: Previous electrochemically-powered yarn muscles cannot be usefully operated between extreme negative and extreme positive potentials, since strokes during electron injection and during hole injection partially cancel because they are in the same direction. Unipolar-stroke carbon nanotube yarn muscles are described in which muscle strokes are additive between extreme negative and extreme positive potentials, and stroke increases with potential scan rate. These electrochemical artificial muscles include an electrically conducting twisted or coiled yarn and a material that dramatically shifts the potential of zero charge of the electrochemically actuated yarn.
    Type: Grant
    Filed: February 3, 2020
    Date of Patent: April 1, 2025
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Hetao Chu, Jinsong Leng, Ray H. Baughman, Xinghao Hu, Na Li, Carter S. Haines, Shaoli Fang, Zhong Wang, Jiuke Mu
  • Patent number: 12264318
    Abstract: Modified ribosomes that were selected using a dipeptidyl-puromycin aminonucleoside are used to mediate site-specific incorporation of one or more peptides and peptidomimetics into protein in a cell free translation system. In addition, new fluorescent dipeptidomimetics have been synthesized and incorporated into proteins, as well as modified proteins containing one or more non-naturally occurring dipeptides.
    Type: Grant
    Filed: July 19, 2022
    Date of Patent: April 1, 2025
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Sidney Hecht, Larisa (Liza) Dedkova, Rumit Maini, Sandipan Roy Chowdhury, Rakesh Paul
  • Patent number: 12264263
    Abstract: Methods and formulations for use of phase change materials (PCMs) as coatings or integrated with building materials are disclosed. A formulation comprises an amount of phase change material, for example a mass fraction of about 0.01 to about 0.50. The PCM materials may be applied as a surface treatment such as paint, for example in order to provide improved thermal regulation to a building or a portion thereof.
    Type: Grant
    Filed: July 9, 2021
    Date of Patent: April 1, 2025
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Matthew Aguayo, Aashay Arora, Narayanan Neithalath
  • Patent number: 12265223
    Abstract: Eye-tracked head-mounted displays are provide which, in one aspect, may utilize the same optics for eyetracking and image viewing, with a selected portion of the optics used for an eyetracking optical path and a selected portion of the display optics used for an image viewing optical path.
    Type: Grant
    Filed: October 29, 2021
    Date of Patent: April 1, 2025
    Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, AUGMENTED VISION INC.
    Inventors: Hong Hua, Chunyu Gao