Abstract: The present invention provides a method for using a tamper-resistant physical unclonable functions (PUF) to generate temporary passwords, encrypt a password manager database for one-way encryption, and authenticate users. Resistive Random-Access Memory (ReRAM) can be exploited as PUFs. On the server side, a ReRAM PUF can be used to change the format of the password manager database. By comparing the resistance values extracted from the ReRAM PUF, a bitstream can be generated which can then be used as a challenge. Furthermore, by utilizing the hash function and the ReRAM PUF, the password manager database's content can be encrypted as a one-way encryption. The resistance values, which are the ReRAM PUF output, are converted to a bitstream and then replace the user ID and password hash in the database.

Abstract: A system and method for the automatic stimulation of a vagus nerve for post-stroke rehabilitation is disclosed. The system includes an application subsystem having an electrode positioned to stimulate the vagus nerve and coupled to a user outside of a surgical setting. The system also includes a waveform generator communicatively coupled to the electrode, and a triggering subsystem including a receiver configured to detect the presence of a tag. The triggering subsystem is communicatively coupled to waveform generator and is configured to automatically trigger the stimulation of the vagus nerve upon detecting the presence of the tag. The tag is located proximate a rehabilitation context such that the tag is detected when the user is using the rehabilitation context, resulting in the vagus nerve of the user being automatically stimulated by the electrode in response to the user's post-stroke rehabilitation training.

Abstract: The present disclosure is directed to a system and method for surgical training with low cost, reusable materials and a highly customizable virtual environment for skill-building. According to various embodiments, a surgical training tool is usable in conjunction with a support structure configured to at least partially constrain the tool movement. Meanwhile, the tool is tracked in real-time with off-tool detectors to generate a tool path driving a virtual rendering of the surgical training tool in an operative environment. The virtual rendering may be visually observable via a display device and may include a customizable and/or selectable operative environment with one or more structures that can be operated on by the virtual surgical training tool. By tracking the virtual tool interaction with the virtual structures, a task path may be established for documenting and/or objectively assessing the performance of one or more operative tasks.

Abstract: Isolated or recombinant anti-EGFL6 monoclonal antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer.

Abstract: A parallel manipulator with six degrees of freedom may include a base that attaches to a unmanned aerial vehicle and a movable gripper element that may be positioned below the UAV. The positioning of the gripper element my reduce impact of the center of gravity of the attached UAV. The gripper element may include a geometric shape that complements objects routinely used in high-throughput screening (HTS) laboratories, such as microplates. The parallel manipulator and gripper element may be used to quickly, safely, and securely move objects in HTS laboratories and/or the like.

Abstract: A sterilization system includes a controller, a transformer including a primary side in communication with the controller and secondary side, an ozone generator in communication with the secondary side of the transformer and the controller, and a power source in communication with the controller, wherein the ozone generator ionizes atmospheric oxygen through the application of corona discharge.

Abstract: Biometric-based graded authentication provides a passive, graded authentication system, which uses face authentication to provide users access to their devices without requiring manual interaction with the lock screen. Biometric-based graded authentication permits users to categorize applications into various security bins based on their sensitivity. By doing so biometric-based graded authentication method grants access to different sensitivity applications, based on varying degrees of confidence in user authentication. Thus, allowing the device to be used even in adverse lighting conditions without hampering user experience. While the use of face authentication is used to discuss the system, biometric-based graded authentication as disclosed herein may be used with any confidence-based biometric system.

Abstract: Devices and methods for nasal administration of a pharmaceutical composition. In certain embodiments, the devices comprises a reservoir, a conduit in fluid communication with the reservoir, and an anatomic positioning device configured to position the conduit in a nasal cavity of a user. Particular embodiments include an actuator configured to transfer the pharmaceutical composition from the reservoir to the conduit and emit the pharmaceutical composition from the conduit.

Abstract: A method of using an ankle exoskeleton device is provided herein. The method includes collecting one or more biomechanical data points from an individual. The method also includes developing individualized musculoskeletal simulations based on the one or more biomechanical data points. In addition, the method includes creating predictive simulations by modeling effects of an ankle exoskeleton device on the individualized musculoskeletal simulations. The method also includes utilizing established device-user relationships with real-time measurements to adjust device control. Lastly, the method includes optimizing design parameters of the exoskeleton device based on the predictive simulations and user responses.

Abstract: Methods, devices and systems that allow three-dimensional printing of material with high resolution are described. One example system includes a two-photon polymerization (TPP) subsystem including a first light source coupled to an optical fiber positioned to deliver a first laser light to a scanning optical device, and an optical projection subsystem comprising a second light source configured to provide a second light to a digital projection device. A dichroic mirror is positioned to receive light corresponding to the first and the second light source, and an objective lens positioned to provide illumination to a target material for 3D printing. The dichroic mirror is configured to allow light from one of the light sources to pass therethrough to the objective lens, and to allow light corresponding to the other light source to be reflected towards the objective lens to enable simultaneous illumination of the target material.

Abstract: Provided herein are, inter alia, methods for identifying subjects suffering from depression that will respond to treatment with an antidepressant.

Abstract: A motor-deficit-therapeutic method (for treatment of a patient who has hemiparesis) includes: providing, to the patient afflicted with a hemiparesis, a neurostimulator configured to stimulate a vagus nerve of the patient using electrical, magnetic, optical, acoustic or mechanical stimulation; and initiating stimulation of the vagus nerve by the neurostimulator so that at least a portion of the stimulation occurs at least during performance by the patient of a motor therapy session which is hemiparesis-therapeutic, thereby improving the patient's hemiparesis.

Abstract: A method and system of 3D cold-spray printing to produce an object by adhering powder grains to a substrate. The powder grains are ionized by injecting the powder grains into an ionizing mechanism to produce ionized powder grains. Next, the ionized powder grains are focused into a stream using an electromagnetic lens, wherein the stream has a thickness approaching the average diameter of the powder grain. The stream is directed at a substrate such that powder grains are deposited on and adhered to the substrate.

Abstract: Predictive modeling of peptide binding motifs of major histocompatibility complex class I (MHC-I) is employed through the application of a predictive machine learning (ML) model. The predictive ML model can utilize structural and biophysical data obtained by modeling the physical structure of the binding pocket of the MHC-I and generating an electrostatic potential distribution of the binding pocket structural model. By utilizing the structural an biophysical data of the binding pocket of the MHC-I, the predictive ML model predicts the amino acid sequence of the peptide binding motif of the MHC-I.

Abstract: The present disclosure is directed to methods of cancer treatment, for example of solid tumors, in which CGRP is inhibited, and optionally is administered in tandem with checkpoint inhibitor immunotherapy (e.g., inhibition of Programmed cell death protein 1 (PD-1), PD-1 ligand, and/or Cytotoxic T-lymphocyte-Associated protein 4 (CTLA-4)) to bolster anti-tumor immunity and lead to tumor rejection. In one non-limiting embodiment, for example, the cancer treated is breast cancer. In this manner, CGRP inhibitors that target neurochemicals secreted by sensory nerves and are used as migraine treatments can be repurposed in anti-tumor therapy.

Abstract: Provided herein are anti-CD5L monoclonal antibodies. Further provided herein are methods of use thereof for the treatment of a disease or disorder, such as cancer.

Abstract: Aspects of the present disclosure are directed to methods for treating a subject having cancer. Certain aspects relate to treating a subject for lung cancer by administering a kinase inhibitor to a subject determined, from analysis of tumor DNA from the subject, to have an EGFR mutation of a particular classification. Further aspects relate to methods for treating a subject for lung cancer by detecting an EGFR mutation of a particular classification in tumor DNA from the subject and administering an effective amount of a kinase inhibitor to the subject. Also disclosed are methods for stratifying and prognosing subjects based on EGFR mutation classification.

Abstract: Aspects of the present disclosure are directed to immune cells comprising polynucleotides encoding genetically engineered receptors (e.g., chimeric antigen receptors, T-cell receptors) and having anti-CD20 antibodies (or fragments thereof) attached to their surface. Certain aspects are directed to preactivated and/or expanded natural killer cells having anti-CD20 antibodies (or fragments thereof) attached to their surface. Also disclosed are compositions comprising such cells, and methods for using such compositions to treat an individual having CD20-positive cancer. Further aspects encompass methods for cell preparation comprising culturing natural killer cells with cytokines (e.g., IL-12, IL-15, and/or IL-18) and incubating the cells with an anti-CD20 antibody.

Abstract: Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.

Abstract: Hybrid in-situ and signal of opportunity (SoOP) calibration for antenna arrays is provided. Deployment of aircraft antennae is redesigned to support multiple services with shared physical elements that conform to the exterior of an aircraft to mitigate drag. Conformal arrays are, however, susceptible to structural changes in the fuselage that manifest as pointing errors and side lobe degradation. Embodiments provide an online calibration algorithm that leverages cooperative satellites in direct line-of-sight of a radio frequency (RF) device with an antenna array (e.g., an aircraft with a conformal antenna array) to optimally steer beams. These external calibration sources supplement an in-situ source mounted on a common platform with the antenna array (e.g., placed on the aircraft's tail). Models are established for potential sources of mismatch and the hybrid calibration method is demonstrated via simulations.