Patents Assigned to Board of Regents for Oklahoma State University
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Patent number: 6821738Abstract: The instant invention pertains generally to a method and apparatus for rapidly detecting nerve agents, organophosphates, and other chemical warfare agents. A sensor has been developed that can be used to rapidly detect multiple analytes such as organic compounds. Analytes can be detected by monitoring changes in the optical properties of the absorbance and/or fluorescence spectra of highly colored heterocyclic compounds such as porphyrins or related compounds such as phthalocyanines. The result is a real-time monitor that is suitable for use in situations where encounter with chemical warfare agents is possible.Type: GrantFiled: July 20, 2001Date of Patent: November 23, 2004Assignee: The Board of Regents for Oklahoma State UniversityInventor: H. James Harmon
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Patent number: 6781696Abstract: A microsphere whispering-gallery mode evanescent-wave sensor for use in the detection and identification of atoms or molecules has been developed. In operation, the species under scrutiny is introduced proximate to a microsphere in which a whispering-gallery mode has been excited. The subject species then absorbs a portion of the microsphere's evanescent light energy at compound-specific wavelengths, which absorption is then used to detect and identify the subject species. Its concentration may be determined from the absorption signal on the light in reflection or transmission. High sensitivity in the instant invention results from the long effective absorption path length provided by the whispering-gallery mode's large Q which results in a detector that is suitable for use in trace-gas sensing. The instant microsphere detection system can rival the performance of a multipass cell and can be made part of a much more compact and rugged system.Type: GrantFiled: December 6, 2002Date of Patent: August 24, 2004Assignees: The Board of Regents for Oklahoma State University, Nomadics, Inc.Inventors: Albert T. Rosenberger, Brian N. Strecker
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Publication number: 20040156865Abstract: Vaccines and methods against M. haemolytica infections in cattle. The vaccine compositions include a recombinant outer membrane protein of M. haemolytica designated PlpE and/or subunits thereof, alone or in combination with other antigenic components, and a carrier or diluent. The methods involve administering an effective immunizing amount of the vaccines to susceptible bovine.Type: ApplicationFiled: October 29, 2003Publication date: August 12, 2004Applicant: The Board of Regents for Oklahoma State UniversityInventors: Anthony W. Confer, Sahlu Ayalew, George L. Murphy, Karamjeet Pandher
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Patent number: 6749945Abstract: An Ormosil composite coating that provides good corrosion and abrasion resistance of the underlying substrate. The Ormosil composite coating of the present invention is entrapped with a plurality of inorganic particles of a size greater than 1 micron to produce a coating of a sufficient, desired thickness. The coating of the present invention, generally includes an ormosil composite including a plurality of entrapped inorganic particles wherein each of the plurality of inorganic particles is at least one (1) micron in its maximum dimension but not greater than 75 microns (however, a maximum dimension of 5 microns is preferred).Type: GrantFiled: January 29, 2002Date of Patent: June 15, 2004Assignee: The Board of Regents for Oklahoma State UniversityInventors: Edward T. Knobbe, Olga Kachurina, Tammy L. Metroke
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Patent number: 6737275Abstract: The invention presents a method designed to simultaneously measure certain unsaturated lipids and certain vitamins present either as single substances or in complex mixtures such as exist in serum and natural oils. Target lipids are free cholesterol, unsaturated cholesteryl esters; free polyunsaturated fatty acids, and their esters as triglycerides, and phospholipids. Distributions of these analytes over the broad range of serum lipoproteins from chylomicrons to high density fractions are determined using a procedure that involves a single step reaction in which the molecular unsaturations are subjected to non-enzymatic color inducing reagents. For natural oils and vitamins, the same method serves as a quality control procedure. Analytical detection is achieved using broad spectrum absorbance and/or fluorescence measurements. Measured spectra are aggregates of the absorbance contributions from each of the analytes. Data analyses follow two paths. One uses raw spectral data.Type: GrantFiled: February 5, 2002Date of Patent: May 18, 2004Assignees: The Board of Regents for Oklahoma State University, University of Cape TownInventors: Neil Purdie, Justin A. Krouse, Joe Studer, Adrian D. Marais
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Publication number: 20040065834Abstract: A spectral reflectance sensor including: a light source for emitting a modulated beam of red light; a light source for emitting a modulated beam of near infrared light; a receiver for receiving reflected light produced by either the red source or the near infrared source; a receiver for receiving incident light from either the red source or the infrared source; a signal conditioner responsive to the modulation such that the signals produced by the receivers in response to reflected and incident light from the source can be discriminated from signals produced by ambient light; and a microprocessor having an input such that the microprocessor can determine the intensities of incident red light, reflected red light; incident near infrared light; and reflected near infrared light. From these intensities, and by knowing the growing days since emergence or planting, the sensor can calculate the mid-growing season nitrogen fertilizer requirements of a plant.Type: ApplicationFiled: June 26, 2003Publication date: April 8, 2004Applicant: The Board of Regents for Oklahoma State UniversityInventors: Marvin L. Stone, Duane Needham, John B. Solie, William R. Raun, Gordon V. Johnson
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Patent number: 6709707Abstract: A process for chemical removal of organically-modified silicate (Ormosil) coatings from aluminum alloy substrates without degradation of the underlying metal. An Ormosil film is treated with a zincate solution. The zincate solution dissolves the Ormosil film and deposits a thin, easily-removed layer of zinc onto the aluminum alloy surface, which prevents base-activated dissolution of the underlying metal. The zinc layer may be removed using dilute phosphoric acid, leaving the surface of the aluminum alloy intact. Consequently, the sol-gel coating may be removed while the integrity of the aluminum alloy substrate is maintained.Type: GrantFiled: September 9, 2002Date of Patent: March 23, 2004Assignee: The Board of Regents For Oklahoma State UniversityInventors: Edward T. Knobbe, Olga Kachurina, Tammy L. Metroke
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Patent number: 6702200Abstract: A nozzle attitude controller for use in connection with a farming apparatus for precision farming, the apparatus comprising an applicator vehicle, a boom supported by and extending across the rear of the vehicle, a manifold rotatably supported by the boom, a plurality of nozzles disposed from the manifold and oriented in a direction opposite to the direction of movement of the vehicle, but disposed at an angle with respect to the horizontal, the attitude controller including a linear actuator operated by a stepper motor and a radar sensor which connects to the stepper motor and which measures the speed of the vehicle such that pulses from the radar sensor to the stepper motor moves the linear actuator to change the angle of the nozzle so that the horizontal component of its velocity is equal and opposite to the speed of the vehicle.Type: GrantFiled: July 24, 2001Date of Patent: March 9, 2004Assignee: The Board of Regents for Oklahoma State UniversityInventors: John B. Solie, Marvin L. Stone, Stewart D. Reed
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Patent number: 6689338Abstract: A bioconjugate including a nanoparticle covalently linked to a biological vector molecule. The nanoparticle is a generally radioactive metal ion and most typically a metal sulfide or metal oxide. The biological vector molecule is typically a monoclonal antibody or fragment of a monoclonal antibody or a peptide having a known affinity to cancer cells. One or more additional, different biological moieties may be covalently linked to the nanoparticle in addition to the biological vector molecule to enhance its activity. The bioconjugate of the present invention has utility as an effective radiopharmaceutical to deliver a radiolabel in tumor treatment.Type: GrantFiled: May 31, 2001Date of Patent: February 10, 2004Assignee: The Board of Regents for Oklahoma State UniversityInventor: Nicholas A. Kotov
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Publication number: 20040022795Abstract: Protective antigens against infestations with Ixodes spp. ticks, gene sequences and encoded proteins for such antigens, related vaccines and methods useful to induce an immune response, which are protective to interfere with infestations by Ixodes spp. ticks.Type: ApplicationFiled: April 29, 2003Publication date: February 5, 2004Applicant: The Board of Regents for Oklahoma State UniversityInventors: Jose de Jesus de la Fuente, Katherine M. Kocan, Consuelo Garcia-Almazan, Jose Carlos Garcia-Garcia, Edmour F. Blouin
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Patent number: 6601341Abstract: A method for in-season fertilizer nitrogen application based on predicted yield potential and a nutrient response index. The inventive method includes the steps of: determining a nutrient response index for a field; determining the normalized difference vegetation index of an area to fertilize; determining a predicted crop yield for the area; determining an attainable crop yield for the area; determining nitrogen uptake for the vegetation within the area; and determining the amount of fertilizer nitrogen required by said vegetation. In one embodiment, the normalized difference vegetation index is determined by scanning an area to fertilize with a spectral reflectance sensor which provides reflectance values for red light and near infrared light. The normalized difference vegetation index (NDVI) is defined by: NDVI=(NIR−red)/(NIR+red) where “NIR” is the reflectance value for near infrared light and “red” is the reflectance value for red light.Type: GrantFiled: July 24, 2001Date of Patent: August 5, 2003Assignee: The Board of Regents for Oklahoma State UniversityInventors: William R. Raun, Gordon V. Johnson, John B. Solie, Marvin L. Stone
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Patent number: 6596996Abstract: A spectral reflectance sensor including: a light source for emitting a modulated beam of red light; a light source for emitting a modulated beam of near infrared light; a receiver for receiving reflected light produced by either the red source or the near infrared source; a receiver for receiving incident light from either the red source or the infrared source; a signal conditioner responsive to the modulation such that the signals produced by the receivers in response to reflected and incident light from the source can be discriminated from signals produced by ambient light; and a microprocessor having an input such that the microprocessor can determine the intensities of incident red light, reflected red light; incident near infrared light; and reflected near infrared light. From these intensities, and by knowing the growing days since emergence or planting, the sensor can calculate the mid-growing season nitrogen fertilizer requirements of a plant.Type: GrantFiled: July 24, 2001Date of Patent: July 22, 2003Assignee: The Board of Regents for Oklahoma State UniversityInventors: Marvin L. Stone, Duane Needham, John B. Solie, William R. Raun, Gordon V. Johnson
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Patent number: 6586460Abstract: Compounds, known as heteroarotinoids, having varying abilities to inhibit growth of certain cancerous cells, induce normal cell differentiation, and induce apoptosis or death of cancerous cells, of the general formula: in which: Ar and Ar′ denote aryl substituents, and wherein at least one of said aryl substituents comprises an aromatic ring having at least one heteroatom in a fused, partially saturated ring; W denotes O or S; and Q denotes H or i-C3H7.Type: GrantFiled: April 2, 2001Date of Patent: July 1, 2003Assignees: The Board of Regents for Oklahoma State University, The Board of Regents for University of OklahomaInventors: Kenneth Darrell Berlin, Doris M. Benbrook, Eldon C. Nelson
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Publication number: 20030007953Abstract: A ruminant direct fed microbial composition of matter comprising an acidosis inhibiting effective amount of Propionibacterium P-63 is provided. Also disclosed is a process for reducing acidosis in ruminants or scours in swine by administration of the bacterium to the ruminant or swine. The microbial composition may be administered by itself, or combined with animal feed and/or lactic acid producing cultures.Type: ApplicationFiled: August 1, 2002Publication date: January 9, 2003Applicant: THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITYInventors: Thomas Rehberger, Terry D. Parrott, Fred N. Owens, Charles A. Hibberd
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Patent number: 6489362Abstract: An effective amount of carnitine is administered to broiler type poultry to prevent or alleviate ascites. In the preferred embodiment, a carnitine supplemented diet is fed to broiler type chickens in a feed composition during the phase of rapid tissue accretion where a high oxygen requirement stresses the birds' cardiovascular support system. The feed composition preferably contains between 5 and 1000 ppm of carnitine.Type: GrantFiled: March 23, 1999Date of Patent: December 3, 2002Assignees: The Board of Regents for Oklahoma State University, Lonza, Inc.Inventors: Robert G. Teeter, Stanley L. Vanhooser, Kevin Q. Owen
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Patent number: 6455063Abstract: A ruminant direct fed microbial composition of matter comprising an acidosis inhibiting effective amount of Propionibacterum P-63 is provided. Also disclosed is a process for reducing acidosis in ruminants or scours in swine by administration of the bacterium to the ruminant or swine. The microbial composition may be administered by itself, or combined with animal feed and/or lactic acid producing cultures.Type: GrantFiled: April 15, 1999Date of Patent: September 24, 2002Assignee: The Board of Regents for Oklahoma State UniversityInventors: Thomas Rehberger, Terry D. Parrott, Fred C. Owens, Charles A. Hibberd
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Patent number: 6413571Abstract: Novel sterol/stanol esters of a conjugated fatty acid are provided through the esterification or transesterification of a sterol such as beta-sitosterol or a hydrogenated form thereof (stanol). Such novel esters exhibit the combined properties normally possess by the sterol/stanol compound and the conjugated fatty acid and as such are excellent additives for dietetic foods and supplements.Type: GrantFiled: October 20, 2000Date of Patent: July 2, 2002Assignee: The Board of Regents for Oklahoma State UniversityInventor: Linsen Liu
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Patent number: 6414324Abstract: The instant invention teaches a method of preparing a luminescent detecting material for use in UV dosimetry which utilizes phototransferred luminescence. The detecting material has a set of shallow dosimetry traps for trapping electronic charge carriers, which are thermally released upon heating to a first temperature, and a set of deep traps for trapping electronic charge carriers, which charge carriers are released upon heating to a second temperature. The detecting material is prepared by irradiating the detecting material to fill the shallow and deep traps with charge carriers, heating the material to release charge carriers from the shallow traps, and then cooling the material. When the detecting material is subsequently exposed to ultraviolet light a proportion of charge carriers will be released from the deep traps to be retrapped in the shallow traps, thereby allowing for the measurement of phototransferred luminescence by thermal or optical stimulation.Type: GrantFiled: May 11, 1999Date of Patent: July 2, 2002Assignee: The Board of Regents for Oklahoma State UniversityInventors: Leslie E. Colyott, Mark S. Akselrod, Stephen W. S. McKeever
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Patent number: 6357681Abstract: A cutter-separator. Product is fluidized under pressure, forced through the bore of a spring and thence through the gaps between the coils of the spring while in its extended condition. When the spring returns to its compressed, or relaxed, condition the product which has been forced through the coils is reduced in size (i.e., cut, partially cut, or mashed, as desired) by the spring. Contaminants which are too large to pass between the coils are ultimately carried to the end of the spring, downstream from the product flow, where they are discharged.Type: GrantFiled: July 18, 2000Date of Patent: March 19, 2002Assignee: The Board of Regents for Oklahoma State UniversityInventors: Timothy J. Bowser, Davey Joe Vadder
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Patent number: 6316782Abstract: This invention relates generally to luminescence techniques for imaging radiation fields and, more specifically, to the use of experimental and mathematical methods to distinguish between dynamic irradiation and static—or other abnormal radiation—exposure conditions for applications in personnel and environ mental radiation dosimetry, or related fields. In more particular, the instant invention provides a rapid and reliable method of detecting abnormal dosimeter exposure conditions over a wide dynamic range of radiation doses, while avoiding significant background interference and stimulation light leakage. Additionally, the preferred embodiment of the instant invention uses a pulsed and synchronized luminescence detection scheme.Type: GrantFiled: June 9, 1999Date of Patent: November 13, 2001Assignee: The Board of Regents for Oklahoma State UniversityInventors: Mark S. Akselrod, Stephen W. S. McKeever