Abstract: Methods and compositions for treating cancer, particularly improved CAR-T methods, are disclosed.

Abstract: An intravascular cutting device described herein uses high-pressure water, saline, or other fluid to cut tissue and other materials including but not limited to calcified tissue, stents, stent grafts, and other devices. In some embodiments, the cutting device includes a working end that has a nozzle with a hole to allow the release of a high-pressure fluid jet. Opposite of the nozzle is a catch plate or deflector anvil that prevents the fluid jet from cutting healthy tissue. The device user will place the item to be cut between the nozzle and catch plate and then advance the device along the item to be cut as the fluid jet is activated, thus cutting the object as it advances.

Abstract: Antimicrobial peptides and methods of use are provided.

Abstract: Disclosed herein are various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Also disclosed are various medical devices for in vivo medical procedures. Included herein, for example, is a surgical robotic device having an elongate device body, a right robotic arm coupled to a right shoulder assembly, and a left robotic arm coupled to a left shoulder assembly.

Abstract: The present invention provides prodrugs and methods of use thereof.

Abstract: Methods and compositions for treating central nervous system diseases and disorders are disclosed. In a particular embodiment, compositions comprising a nitrated alpha synuclein peptide are provided. The composition may further comprise an adjuvant that stimulates regulatory T cells and/or at least one pharmaceutically acceptable carrier.

Abstract: An apparatus for wrist and catheter stabilization during radial artery access includes a wrist support member and a catheter support member connected by an adjustable coupler. The wrist support member comprises a first platform with a curved surface configured to cradle a wrist in a supine or neutral position and an inclined portion to motivate extension or ulnar flexion of the wrist. The catheter support member comprises a second platform with a curved sidewall extending along at least one side of the second platform. The curved sidewall may be configured to direct a catheter toward a radial access point of the wrist when the catheter is extended across the platform portion of the catheter support member. The adjustable coupler is reconfigurable to control a height of the catheter support member from the wrist support member, as well as orientation and other height/distance parameters in some embodiments.

Abstract: The present disclosure is directed to a system and method for surgical training with low cost, reusable materials and a highly customizable virtual environment for skill-building. According to various embodiments, a surgical training tool is usable in conjunction with a support structure configured to at least partially constrain the tool movement. Meanwhile, the tool is tracked in real-time with off-tool detectors to generate a tool path driving a virtual rendering of the surgical training tool in an operative environment. The virtual rendering may be visually observable via a display device and may include a customizable and/or selectable operative environment with one or more structures that can be operated on by the virtual surgical training tool. By tracking the virtual tool interaction with the virtual structures, a task path may be established for documenting and/or objectively assessing the performance of one or more operative tasks.

Abstract: This document describes devices, systems, and methods for automatically deploying intravascular devices. For example, this document describes devices, systems, and methods for automatically deploying and controlling intravascular catheter-based devices for treating catastrophic bleeding from large and medium size vessels such as, but not limited to, the aorta or iliac arteries. In some embodiments, an operator/care giver will simply press the system against the patient's body proximate to a desired site of insertion, or will attach the system to the patient proximate to the desired site of insertion. The operator will then activate the system. Thereafter, the system will use built in imaging (e.g., ultrasound) to locate a proper insertion point and then deploy an access needle to attain vascular access. With that, the system will then automatically insert the intravascular device into the patient.

Abstract: Compositions and methods for the treatment of peripheral artery disease and cardiopulmonary diseases or disorders are provided. In accordance with the instant invention, methods of inhibiting, treating, and/or preventing peripheral artery disease or symptoms associated therewith are provided. In a particular embodiment, the methods inhibit, treat, and/or prevent claudication associated with peripheral artery disease.

Abstract: Disclosed herein are gross positioning systems for use with robotic surgical devices to provide gross positioning of the robotic surgical devices. The gross positioning systems have a base, a first arm link operably coupled to the base, a second arm link operably coupled to the first arm link, a third arm link operably coupled to the second arm link, and a slidable coupling component slidably coupled to the third arm link.

Abstract: Disclosed herein are examples of user-paced exercise equipment, as well as related circuitry, methods, and computer-readable media. For example, disclosed herein is a user-paced treadmill, including a belt, a motor coupled to the belt, and control circuitry communicatively coupled to the motor. The control circuitry may be configured to change a velocity of the belt based at least in part on a body velocity and a leg swing velocity of a user of the user-paced treadmill.

Abstract: An antimicrobial composition containing a synergistic combination of an imidazole antifungal agent and activated creatinine is provided, wherein the imidazole antifungal agent represents in the range of about 0.5 mol % to about 30 mol % of the combination of the antifungal agent and the activated creatinine in the composition. Methods for treating bacterial infections, fungal infections, viral infections, and wounds are also provided, as are other methods of use, including methods for disinfecting inert surfaces, methods for preserving food products, and methods for treating plants. In addition, the invention provides a method for enhancing the antifungal effect of an imidazole antifungal agent as well as a method for enhancing the antibacterial effect of activated creatinine. Compositions and methods involving use of activated 2-amino-imidazol-4-one analogs other than activated creatinine are also provided.

Abstract: The embodiments disclosed herein relate to various robotic and/or in vivo medical devices having compact joint configurations. Other embodiments relate to various medical device components, including forearms having grasper or cautery end effectors, that can be incorporated into certain robotic and/or in vivo medical devices.

Abstract: In accordance with embodiments of this disclosure, a computational simulation platform comprises a computer-implemented method that includes: generating a mesh or meshless three-dimensional (3D) reconstruction of a vessel lumen and a surface of the vessel lumen based on invasive or non-invasive imaging; assigning material properties to the 3D reconstructed surface of the vessel lumen based on the invasive or non-invasive imaging; performing balloon pre-dilation, stenting and balloon post-dilation computational simulations with the 3D reconstructed vessel lumen and surface of the vessel lumen; and assessing stent and vessel morphometric and biomechanical measures based on the computational simulations.

Abstract: Disclosed herein are inhibitors of the GGDPS enzyme, and methods for their use in treating or preventing diseases, such as multiple myeloma. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein the substituents are described.

Abstract: The various embodiments herein relate to robotic surgical systems and devices that use force and/or torque sensors to measure forces applied at various components of the system or device. Certain implementations include robotic surgical devices having one or more force/torque sensors that detect or measure one or more forces applied at or on one or more arms. Other embodiments relate to systems having a robotic surgical device that has one or more sensors and an external controller that has one or more motors such that the sensors transmit information that is used at the controller to actuate the motors to provide haptic feedback to a user.

Abstract: Disclosed is a Processing-In-Sensor Accelerator (PISA) that provides a flexible, energy-efficient, and high-performance solution for real-time and smart image processing in AI devices. PISA implements a coarse-grained convolution operation in Binarized-Weight Neural Networks (BWNNs) leveraging a novel compute-pixel with non-volatile weight storage at the sensor side. This reduces power consumption of data conversion and transmission to an off-chip processor. A bit-wise near-sensor in-memory computing unit processes the remaining network layers. Once the object is detected, PISA switches to typical sensing mode to capture the image for a fine-grained convolution using only a near-sensor processing unit. The circuit-to-application co-simulation results on a BWNN acceleration demonstrate minor accuracy degradation on various image datasets in coarse-grained evaluation compared to baseline BWNN models. PISA achieves a frame rate of 1000 and efficiency of 1.74 TOp/s/W.

Abstract: A system for reporting and investigating threats includes one or more computer processors configured to: present a chatbot via a user interface device; request response data associated with a threat inquiry via the chatbot by requesting freeform response data associated with the threat inquiry via the chatbot and transitioning to intelligent question-path selection to collect additional response data associated with the threat inquiry, wherein the intelligent question-path selection is prompted by the freeform response data; record user input response data; and identify suspicious activity based on the user input response data by performing natural language analysis and searching the user input response data for threat related words or phrases.