Abstract: The various embodiments herein relate to a coupling apparatus for a medical device having a coupler body, a cavity defined in the coupler body, a rotatable drive component disposed within the cavity and having at least two pin-receiving openings, and an actuable locking ring disposed around the cavity.
Type:
Grant
Filed:
August 25, 2017
Date of Patent:
November 16, 2021
Assignee:
BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
Abstract: A precision syringe includes a syringe barrel and plunger that has a base, an internal portion, and an external portion. The internal portion of the plunger extends longitudinally into the syringe barrel. The internal portion has a first end coupled to the base and a second end that is configured to push fluid out of and/or suction fluid into the syringe barrel. The external portion extends longitudinally along an outer surface of the syringe barrel. The external portion has a first end coupled to the base and a second end that is configured to receive an applied force that causes the plunger to move relative to the syringe barrel so that the second end of the internal portion is actuated through a portion of the syringe barrel (e.g., to dispense fluid from or suction fluid into the syringe barrel).
Type:
Grant
Filed:
February 15, 2018
Date of Patent:
November 9, 2021
Assignee:
Board of Regents of the University of Nebraska
Abstract: There is described a platform device for use in forming an anastomosis and maintaining a desired curvature of a lumen in a desired shape during an anastomosis assistance period. The platform is formed from one or more bioabsorbable or biodegradable polymer filaments. There is also described a method for inserting a platform device for use in creation of an arteriovenous fistula by identifying a candidate artery and a candidate vein and dissecting the candidate vein. Next, inserting a platform device into the vein and creating a breach in the candidate artery at a desired angle and location. Next, introducing the platform device and vein into the candidate artery and forming the platform device into a curvature angle selected to minimize turbulent blood flow in an anastomosis formed by the vein and the artery. The platform may also be used to maintain potency of supply blood vessels and/or organ blood vessels or the lumens daring an organ transplant procedure.
Type:
Grant
Filed:
August 29, 2019
Date of Patent:
November 2, 2021
Assignee:
Board of Regents of the University of Nebraska
Abstract: A system and methods for the delivery of oxygen through a body cavity of a subject using oxygen microbubbles. Through circulation of oxygen microbubbles through the body cavity, oxygen and carbon dioxide exchange may occur. Overall improvement in extending survival rate time during emergency situations caused by pulmonary or similar oxygen-intake restricting injury and/or failure may be achieved through use of the invented system and methods.
Type:
Grant
Filed:
November 2, 2018
Date of Patent:
October 12, 2021
Assignees:
The Regents of the University of Colorado, a Body Corporate, Board of Regents of the University of Nebraska
Abstract: Various liquid and semisolid lubricant compositions are provided, in particular lubricant compositions containing oil from the seeds of the Brassicaceae Orychophragmus violaceus, preferably those that have been esterified with one or more fatty acids such as palmitoleic acid, oleic acid, linoleic acid, lauric acid, palmitic acid, stearic acid, or a combination thereof. In various aspects, lubricant compositions are provided that include a petroleum or a synthetic base oil and about 40% or less by weight of a liquid lubricant composition containing oil from the seeds of the Brassicaceae Orychophragmus violaceus, preferably those that have been esterified with one or more fatty acids. In various aspects, semisolid lubricant composition are provided containing an emulsion of (i) a thickener and (ii) an oil from the seeds of the Brassicaceae Orychophragmus violaceus, preferably those that have been esterified with one or more fatty acids.
Type:
Grant
Filed:
December 14, 2018
Date of Patent:
October 5, 2021
Assignees:
University of North Texas, Board of Regents of the University of Nebraska, Indiana University Research and Technology Corp, Huazhong Agricultural University
Inventors:
Diana Berman, Kent Dean Chapman, Tervor Bradley Romsdahl, Edgar Benjamin Cahoon, Robert Earl Minto, Chunyu Zhang
Abstract: A medication bottle includes an outer container wall, an inner container wall and a fluid, such as an aversive liquid, located between the walls. In another aspect, the fluid is located within separate compartments or channels located between the walls where the walls contact or are secured to each other. A further aspect provides a removeable cap including multiple sensors, at least one of which is a biometric sensor.
Type:
Grant
Filed:
September 13, 2019
Date of Patent:
October 5, 2021
Assignees:
Board of Trustees of Michigan State University, Board of Regents of the University of Nebraska
Inventors:
Bahar Aliakbarian, Muhammad Rabnawaz, Susan E. Selke, Krystal Cheng, Arun Ross, Austin Cozzo, Anurag Chowdhury, Ali Tamayol, Carina Russell, Prem Chahal
Abstract: An engineered payload-delivery system includes a target cell binding unit, covalently bound to a pore forming unit, and a payload portion adapted with a region capable of non-covalently binding to the pore forming unit. The pore forming unit is derived from a particular sub-serotype of Clostridium toxin, while the payload region is derived from a different sub-serotype of Clostridium toxin. The disclosed chimeric protein-based composition is capable of specifically delivering payload to neural cells.
Type:
Grant
Filed:
April 21, 2020
Date of Patent:
September 14, 2021
Assignee:
The Board of Regents of the University of Nebraska
Inventors:
Benjamin J. Pavlik, Paul Blum, Kevin Van Cott
Abstract: An intravascular cutting device described herein uses high-pressure water, saline, or other fluid to cut tissue and other materials including but not limited to calcified tissue, stents, stent grafts, and other devices. In some embodiments, the cutting device includes a working end that has a nozzle with a hole to allow the release of a high-pressure fluid jet. Opposite of the nozzle is a catch plate or deflector anvil that prevents the fluid jet from cutting healthy tissue. The device user will place the item to be cut between the nozzle and catch plate and then advance the device along the item to be cut as the fluid jet is activated, thus cutting the object as it advances.
Type:
Grant
Filed:
June 13, 2018
Date of Patent:
September 14, 2021
Assignee:
Board of Regents of the University of Nebraska
Inventors:
Jason N. MacTaggart, Alexey Kamenskiy, Paul Deegan
Abstract: A number of improvements are provided relating to computer aided surgery. The improvement relates to both the methods used during computer aided surgery and the devices used during such procedures. Some of the improvement relate to controlling the selection of which data to display during a procedure and/or how the data is displayed to aid the surgeon. Other improvements relate to the structure of the tools used during a procedure and how the tools can be controlled automatically to improve the efficiency of the procedure. Still other improvements relate to methods of providing feedback during a procedure to improve either the efficiency or quality, or both, for a procedure.
Type:
Grant
Filed:
August 20, 2015
Date of Patent:
September 14, 2021
Assignee:
Board of Regents of the University of Nebraska
Abstract: Provided herein are compounds and methods for modulating the NF?B pathway. More particularly, provided are inhibitors of the NF?B pathway and the uses of such inhibitors in regulating diseases and disorders, e.g., to treat cancer, autoimmune diseases, inflammatory diseases, diabetes, cardiovascular diseases, or neurological diseases.
Type:
Grant
Filed:
December 21, 2017
Date of Patent:
August 31, 2021
Assignee:
BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
Abstract: The embodiments disclosed herein relate to various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices, and more specifically including end effectors that can be incorporated into such devices. Certain end effector embodiments include various vessel cautery devices that have rotational movement as well as cautery and cutting functions while maintaining a relatively compact structure. Other end effector embodiments include various end effector devices that have more than one end effector.
Type:
Grant
Filed:
July 16, 2019
Date of Patent:
July 20, 2021
Assignee:
Board of Regents of the University of Nebraska
Inventors:
Shane Farritor, Thomas Frederick, Joe Bartels
Abstract: The present invention is directed to an oral supplement including creatine hydrochloride, which has an aqueous solubility that is at least 15 times greater than creatine monohydrate, where the oral supplement drives significant improvements in muscle development and recovery due to its enhanced bio-availability, while causing fewer negative side effects compared to previous forms of creatine.
Type:
Application
Filed:
January 4, 2021
Publication date:
July 8, 2021
Applicants:
Vireo Systems, Inc., Board of Regents of the University of Nebraska
Inventors:
Donald W. Miller, Jonathan L. Vennerstrom, Mark C. Faulkner
Abstract: The embodiments disclosed herein relate to various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Certain embodiments include various modular medical devices for in vivo medical procedures.
Type:
Grant
Filed:
November 20, 2019
Date of Patent:
July 6, 2021
Assignee:
Board of Regents of the University of Nebraska
Inventors:
Shane Farritor, Erik Mumm, Philip Chu, Nishant Kumar, Jason Dumpert, Yutaka Tsutano
Abstract: A healthcare provider user interface for treatment option and authorization is disclosed herein. In embodiments, a healthcare provider device includes a display coupled to one or more processors. The display includes a graphical user interface comprising one or more input interface display pages and one or more output interface display pages. The one or more input interface display pages may include one or more input boxes configured to receive information including patient physiological information, insurance provider information, historical medication prescriptions, and one or more medical diagnoses. The one or more output interface display pages may include a medication list generated based on the received information and a prior authorization form configured to receive one or more prior authorization input fields.
Type:
Grant
Filed:
December 6, 2018
Date of Patent:
June 22, 2021
Assignee:
Board of Regents of the University of Nebraska
Abstract: Disclosed herein are inhibitors of the GGDPS enzyme, and methods for their use in treating or preventing diseases, such as multiple myeloma. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein the substituents are described.
Type:
Grant
Filed:
April 25, 2018
Date of Patent:
June 15, 2021
Assignees:
BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA, UNIVERSITY OF IOWA RESEARCH FOUNDATION
Abstract: A new and distinct interspecific hybrid Corylus plant named ‘OSU 541.147’ characterized by a vigorous, upright growth habit, the production of nuts with round kernels that fall free of the husk at maturity, and resistance to eastern filbert blight caused by the fungus Anisogramma anomala (Peck) E. Müller.
Type:
Grant
Filed:
August 28, 2020
Date of Patent:
October 19, 2021
Assignees:
Oregon State University, Rutgers, the State University of New Jersey, Board of Regents of the University of Nebraska, Arbor Day Foundation