Abstract: Embodiments of a material having low cross-plane thermal conductivity are provided. Preferably, the material is a thermoelectric material. In general, the thermoelectric material is designed to block phonons, which reduces or eliminates heat transport due to lattice vibrations and thus cross-plane thermal conductivity. By reducing the thermal conductivity of the thermoelectric material, a figure-of-merit (ZT) of the thermoelectric material is improved. In one embodiment, the thermoelectric material includes multiple superlattice periods that block, or reflect, multiple phonon wavelengths.

Abstract: The present invention is a method for detecting and destroying cancer tumors. The method is based on the concept of associating a linking protein or linking peptide such as, but not limited to, annexin V or other annexins to carbon nanotubes such as single-walled carbon nanotubes (SWNTs) to form a protein-CNT complex. Said linking protein or peptide can selectively bind to cancerous cells, especially tumor vasculature endothelial cells, rather than to healthy ones by binding to cancer-specific external receptors such as anionic phospholipids including phosphatidylserine expressed on the outer surfaces of cancer cells only. Irradiation of bound CNTs with one or more specific electromagnetic wavelengths is then used to detect and destroy those cells to which the CNTs are bound via the linking protein or peptide thereby destroying the tumor or cancer cells and preferably an immunostimulant is provided to the patient to enhance the immune response against antigens released from the tumor or cancer cells.

Abstract: A computer system having a processor, non-transitory memory and a communication system is described. The communication system is coupled to a network and communicates with one or more genetic databases using an internet protocol. The non-transitory memory stores processor executable code to cause the processor to (1) receive data indicative of genetic array data of a patient via the communication system, (2) conduct, via the communication system and the network, at least one query of one or more genetic databases of genotypic data and phenotypic data using the data indicative of patient genetic data and phenotypic data, and (3) provide results of the at least one query to provide a clinical synopsis of the patient.

Abstract: Compositions comprising antibodies raised against CAP37 and isoforms thereof, along with antigen binding fragments thereof, are disclosed. These compositions have many uses, such as in detection of CAP37 and as an early detection marker for various disease conditions. In addition, the compositions may be used therapeutically to inhibit, mitigate, or modulate certain cellular activities involving CAP37 or to monitor a disease progression or the success of a disease treatment.

Abstract: A method of treating a disease or condition associated with at least one of a cellular accumulation of unfolded and/or misfolded proteins, an abnormal unfolded protein response (UPR), an endoplasmic reticulum (ER) stress, and an abnormal autophagy response, is disclosed.

Abstract: Algorithms stored on one or more computer readable medium for interfacing an imaging display with an electronic-ink generating system are described. The algorithms includes instructions for capturing an electronic-ink image, instructions for converting the electronic ink image into control instructions for controlling an electromechanical aspect of the imaging display, and, instructions for providing the control instructions to control circuitry of the imaging display. Interfacing projection systems and methods of interfacing electronic-ink images are also described.

Abstract: The present invention provides sulfoxide compounds comprising hydrophobic ester or amide moieties such that the compounds have surfactant properties. Also provided are methods for using the sulfoxide compounds or mixtures of the sulfoxide compounds in a variety of applications.

Abstract: A catheter with temperature sensing has a catheter body and a tip section with integrated thermoresistive temperature sensors on its outer surface. The temperature sensor includes a microfabricated thin film assembly of which one layer is a sensor layer of thermoresistive material. In one embodiment, the tip section has a flexible tubing on whose outer surface circumferential temperature sensors are integrated. In another embodiment, the tip section has a tip electrode on whose outer surface a tip temperature sensor is integrated. In yet another embodiment, the tip section has a tip temperature sensor integrated on its tip electrode and multiple circumferential temperature sensors distal of the tip temperature sensor.

Abstract: Compositions, methods, and systems are disclosed for the development and use of heparosan, a natural polymer related to heparin, as a new therapeutic modifying agent or vehicle which can modulate drug cargo pharmacokinetics and behavior within a mammalian patient.

Abstract: Compositions that include isolated, functionally active, recombinantly produced class I HLA trimolecular complexes that include epitopes unique to breast cancer cells are disclosed.

Abstract: The present invention in one embodiment uses detection of isoforms of CAP37 as an early detection marker for a chronic inflammatory-associated disease. Chronic inflammatory-related diseases may include, for example, atherosclerosis, psoriasis, and osteoarthritis. The invention is also directed to isoforms of CAP37 protein having apparent molecular weights of about 135 kDa (±15 kDa) and about 100 kDa (±15 kDa) as assessed by SDS PAGE under reducing conditions, and their use as biomarkers for the presence of a chronic inflammatory-associated disease in a subject. The invention is also directed to monoclonal and/or polyclonal antibodies raised against such isoforms of CAP37 protein and kits and diagnostic tests comprising these antibodies.

Abstract: In some embodiments, the present invention provides isolated nucleotide sequences that encode Clostridium difficile toxin B, wherein the isolated nucleotide sequences have been optimized for improved expression of the toxin B in a bacterial cell. Other embodiments of the present invention pertain to methods of expressing recombinant Clostridium difficile toxin B in a bacterial cell from the isolated nucleotide sequences of the present invention. In other embodiments, the present invention pertains to bacterial cells that comprise the isolated nucleotide sequences of the present invention. In further embodiments, the invention pertains to isolated peptides of recombinant Clostridium difficile toxin B that were derived from the isolated nucleotide sequences of the present invention.

Abstract: Inflammatory bowel diseases are represented by two idiopathic disorders, which include ulcerative colitis and Crohn's disease. Ulcerative colitis is restricted to the colon and involves uncertain and inflammation of the lining (mucosa) of the large intestine. Crohn's disease, on the other hand, can involve the mucosa of the small and/or large intestine and may involve deeper layers of the bowel wall. The present invention is a combination of 5-aminosalicylic acid and one or more antioxidants (e.g., N-acetylcysteine) for treating such inflammatory bowel diseases.

Abstract: Anionic non-phospholipids, as well as lipid nanostructures formed therefrom, are disclosed herein. Also disclosed are methods of producing and using same.

Abstract: An apparatus and method for evaluating mechanical properties of geo-materials. The apparatus having a first platen and second platen defining a test specimen receiving space there between, a shaft having one end contacting one of the platens, and a rotatable a rotatable cam having at least one lobe extending from a peripheral surface thereof. The cam being positioned relative to the shaft such that the lobe is engagable with the shaft in such a way that a cyclical axial load is applied to a test specimen when the test specimen is positioned in the test specimen receiving space between the first platen and the second platen and the cam is rotated so as to cause the lobe to cyclically apply an axial force to the shaft.

Abstract: A method for predicting mechanical properties of a transverse isotropic region of a rock formation traversed by a well bore including running a logging tool in the well bore; the mass percentages of minerals present in the rock formation surrounding the well bore are measured with the logging tool. The density of the minerals present in the rock formation surrounding the well bore is determined. The porosity of the rock formation surrounding the well bore is measured. From the porosity and the measured mass percentages and density of the minerals, all the transverse isotropic elastic coefficients of the rock formation are determined in real time.

Abstract: The invention relates to the polynucleotide sequence of a nontypeable stain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and/or the nasopharynx.

Abstract: Embodiments of a material having low cross-plane thermal conductivity are provided. Preferably, the material is a thermoelectric material. In general, the thermoelectric material is designed to block phonons, which reduces or eliminates heat transport due to lattice vibrations and thus cross-plane thermal conductivity. By reducing the thermal conductivity of the thermoelectric material, a figure-of-merit (ZT) of the thermoelectric material is improved. In one embodiment, the thermoelectric material includes multiple superlattice periods that block, or reflect, multiple phonon wavelengths.

Abstract: A method for directly growing carbon nanotubes, and in particular single-walled carbon nanotubes on a flat substrate, such as a silicon wafer, and subsequently transferring the nanotubes onto the surface of a polymer film, or separately harvesting the carbon nanotubes from the flat substrate.

Abstract: The invention relates to the polynucleotide sequence of a nontypeable stain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and/or the nasopharynx.