Patents Assigned to Board of Regents of the University of Texas System
  • Patent number: 11415456
    Abstract: Certain embodiments are directed to an acoustograph or acoustic sensor configured as a thermometer or direct specific absorption rate (DSAR) sensor for the measurement of electromagnetic energy.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: August 16, 2022
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Luisiana Cundin, Norman Barsalou, Shannon Voss, Saher Maswadi, Randolph D Glickman
  • Patent number: 11413613
    Abstract: A method and system for performing biomolecule extraction are provided that use liquid-to-liquid extraction (LLE) in combination with an electrowetting on dielectric (EWOD) device to provide a biomolecule extraction solution that has high extraction efficiency and that is less costly and easier to use than current state of the art methods and systems. The system and method are well suited for, but not limited to, extraction of DNA, RNA and protein molecules.
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: August 16, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Hyejin Moon, Shubhodeep Paul
  • Patent number: 11413329
    Abstract: The present invention is directed to cancer cell traps and methods of using cancer cell traps to treat and detect metastatic cancer in subjects. The cancer cell traps are administered to subjects and induce the migration and accumulation of metastatic cancer cells in the cancer cell traps.
    Type: Grant
    Filed: October 19, 2013
    Date of Patent: August 16, 2022
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventor: Liping Tang
  • Patent number: 11413336
    Abstract: The present invention concerns methods and compositions for treating or preventing a fungal infection, particularly infection by a Coccidioides species. The invention provides methods and compositions for stimulating an immune response against the fungus. In certain embodiments, the methods and compositions involve a recombinant vaccine.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: August 16, 2022
    Assignees: Board of Regents, The University of Texas System, The University of Massachusetts
    Inventors: Chiung-Yu Hung, Gary Ostroff, Natalia Castro-Lopez
  • Patent number: 11413240
    Abstract: The present disclosure provides methods and compositions for the treatment of oral lesions in a subject comprising a methylene blue oral rinse.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: August 16, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventor: Carlos Julio Roldan
  • Publication number: 20220249033
    Abstract: Apparatus and methods for imaging a region of a subject comprising an artifact. In certain embodiments, the apparatus and methods utilize computed tomography (CT) scans obtained at two different angles to image a region posterior to an artifact.
    Type: Application
    Filed: June 10, 2020
    Publication date: August 11, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: David FOLLOWILL, Stephen KRY, Daniela BRANCO
  • Publication number: 20220249874
    Abstract: The present disclosures describes a remotely controlled stereotactic radiotherapy system. The system may include a gamma-ray irradiation system for radioablation of a target region of human tissue, the system having an irradiating unit configured to produce a radiation field, and a processor remote from the gamma-ray irradiation system configured to control the dosage and position of the radiation field applied to the target region.
    Type: Application
    Filed: July 13, 2020
    Publication date: August 11, 2022
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Xuejun GU, David PARSONS
  • Publication number: 20220249867
    Abstract: The present disclosure is directed towards a treatment planning system for use in a stereotactic radiotherapy system. In particular, the disclosed systems and methods may be used for generating a treatment plan and/or verifying an existing treatment plan. Moreover, the disclosed systems and methods may be suitable for use in a clinical setting. A method for verifying a treatment plan of a stereotactic radiotherapy device may include the steps of receiving a treatment plan, generating a second treatment plan by applying a modified monte-carlo method to regions of interest in the treatment plan, and identifying discrepancies between the received treatment plan and the generated second treatment plan.
    Type: Application
    Filed: July 13, 2020
    Publication date: August 11, 2022
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Weigo LU, Xuejun GU, Mingli CHEN, Xun JIA, Steve Bin JIANG
  • Patent number: 11406643
    Abstract: Provided herein are methods for the treatment of brain metastasis by administering a kinase inhibitor targeted to a metastasis-promoting kinase identified by an in vivo kinase screen.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: August 9, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Dihua Yu, Frank Lowery, Chenyu Zhang, Sunil Acharya, Ping Li
  • Patent number: 11406722
    Abstract: Stable perfluorocarbon nanodroplet compositions with properties such as low-boiling points and small particle diameters are provided for improved performance in ultrasound imaging and therapeutic applications. Methods of producing stabilized nanodroplet compositions and methods of using the compositions are further provided to allow for improved performance in ultrasound imaging techniques and/or therapeutic applications.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: August 9, 2022
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Caroline de Gracia Lux, Jacques Lux, Alexander M. Vezeridis, Robert F. Mattrey
  • Patent number: 11407752
    Abstract: A series of substituted 4,6-dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3?-indoline]-2?,5(3H)-dione analogues, the use thereof and the preparation thereof.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: August 9, 2022
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Jia Zhou, Pei-Yong Shi, Jimin Xu, Xuping Xie
  • Patent number: 11408096
    Abstract: Described herein is the application of centrifugal spinning to provide a flexible mechanoluminescent material composed of rare earth metal doped fibers. Rare earth metal doped fibers are formed, in one embodiment, by centrifugal spinning.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: August 9, 2022
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Karen Lozano, Yuanbing Mao, Carlos Hernandez, Misael E. Martinez, Mark Anthony Ruiz, Jorge Ernesto Vidal, Jose Zuniga
  • Patent number: 11407105
    Abstract: A dielectric elastomer system (DES) variable stiffness actuator (VSA) is provided. In an embodiment, the DES VSA includes a variable stiffness module (VSM). The VSM includes a DES that softens when energized and stiffens when unpowered, an outer frame, and an inner frame member. The stiffness of the DES is variable. The outer frame supports the DES and the inner frame member, which is disposed within the DES. The inner frame member is configured to be displaceable with respect to the outer frame. The DES VSA also includes an actuation motor mechanically coupled to the inner frame member that is configured to cause a force to be applied to the inner frame member and the actuation motor is configured to control an equilibrium position of the DES VSA.
    Type: Grant
    Filed: December 15, 2020
    Date of Patent: August 9, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Robert D. Gregg, IV, Edgar A. Bolivar, David P. Allen, Walter E. Voit
  • Publication number: 20220242854
    Abstract: Small molecule disruptors of Beclin-1/Bc1-2 protein-protein interactions induce autophagy and hence are useful for treating a variety of indications where stimulation of autophagy is therapeutically useful, including cancer, infection immunity, neurodegeneration, longevity.
    Type: Application
    Filed: April 5, 2022
    Publication date: August 4, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Jef De Brabander, Qiren Liang, Beth Levine, Wei-Chung Chiang
  • Patent number: 11400096
    Abstract: Certain embodiments are directed to methods of treating autoimmune disorders by administering P2 purnergic receptor antagonist and/or adenosine receptor antagonists. The P2 purnergic receptor antagonist being chemical analogs of adenosine receptor antagonist 8-Ethoxy-9-ethyl-9H-purin-6-amine. The adenosine receptor antagonists being chemical analogs of the non-hydrolysable ATP analog adenosine 5?[?-thio]triphosphate (ATP?S). Certain embodiments are directed to the use of the chemical analogs to modulate IL-17 activity.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: August 2, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventor: Jean X. Jiang
  • Patent number: 11401510
    Abstract: Described herein is a method of generating in-vitro differentiated airway basal cells and compositions thereof. Also described herein is a method of treating a pulmonary disease comprising administering the in-vitro differentiated airway basal cells and compositions thereof. In another aspect, described herein is a disease model comprising patient-derived or genetically modified in-vitro differentiated airway basal cells and compositions thereof.
    Type: Grant
    Filed: February 19, 2021
    Date of Patent: August 2, 2022
    Assignees: TRUSTEES OF BOSTON UNIVERSITY, THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Finn Joseph Hawkins, Darrell N. Kotton, Shingo Suzuki, Brian R. Davis, Cristina Barillà
  • Patent number: 11400108
    Abstract: Disclosed herein are new cyclic dinucleotide compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of modulation of immune response to disease, and induce Stimulator of Interferon Genes (STING) dependent type I interferon production and co-regulated genes in a human or animal subject are also provided for the treatment diseases such as cancer, particularly metastatic solid tumors and lymphomas, inflammation, allergic and autoimmune disease, infectious disease, and for use as anti-viral agents and vaccine adjuvants.
    Type: Grant
    Filed: October 7, 2020
    Date of Patent: August 2, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Maria Emilia Di Francesco, Philip Jones, Michael A. Curran
  • Patent number: 11400444
    Abstract: Open tubular capillary columns for liquid and ion chromatography, based upon an ionically impermeable polyolefin capillary having a bore with a sulfonate-group- or amine-group-functionalized internal surface. The capillary columns may include a coating of ion exchanging nanoparticles electrostatically bound to the functionalized internal surface. The capillary columns may be made by exposing the interior surface to a sulfonating reagent comprising chlorosulfonic acid (ClSO3H), preferably from 85 wt % to 95 wt % chlorosulfonic acid at a process temperature of 20 to 25° C. The interior surface may be subsequently exposed to an asymmetrical diamine to form a sulfonic mid-linkage to the diamine, i.e., to form a sulfonamide-linked, amine-group-functionalized internal surface. The coating may be provided by subsequently exposing the interior surface to an aqueous suspension of ion exchanging nanoparticles to electrostatically bond the ion exchanging nanoparticles to the functionalized internal surface.
    Type: Grant
    Filed: September 16, 2020
    Date of Patent: August 2, 2022
    Assignees: Board of Regents, University of Texas System, Dionex Corporation
    Inventors: Purnendu K. Dasgupta, Weixiong Huang, Christopher A. Pohl
  • Patent number: 11401243
    Abstract: The present invention relates to quinoline derived small molecule inhibitors of nicotinamide N-methyltransferase (NNMT), the preparation thereof and uses thereof. Formula (I).
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: August 2, 2022
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Stanley Watowich, Harshini Neelakantan, Hua-Yu Wang, Stanton Mchardy
  • Patent number: 11403495
    Abstract: A machine learning system efficiently detects faults from three-dimensional (“3D”) seismic images, in which the fault detection is considered as a binary segmentation problem. Because the distribution of fault and nonfault samples is heavily biased, embodiments of the present disclosure use a balanced loss function to optimize model parameters. Embodiments of the present disclosure train a machine learning system by using a selected number of pairs of 3D synthetic seismic and fault volumes, which may be automatically generated by randomly adding folding, faulting, and noise in the volumes. Although trained by using only synthetic data sets, the machine learning system can accurately detect faults from 3D field seismic volumes that are acquired at totally different surveys.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: August 2, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Xinming Wu, Yunzhi Shi, Sergey Fomel