Abstract: A method for eliminating hydrocarbon fouling and reducing pumping power during hydrocarbon transportation. A dielectric layer covers the inner surface of a pipeline for transporting a water-hydrocarbon mixture. A proximity electrode is immersed in the water-hydrocarbon mixture, and an electrical voltage is applied across the dielectric layer. A buffer layer of water is formed on the dielectric layer since water is electrically attracted from the water-hydrocarbon mixture. This water layer, located between the dielectric layer and the water-hydrocarbon mixture, eliminates hydrocarbon fouling on the inner surface of the pipeline or any other internal surface that needs fouling protection. Alternatively, the dielectric layer covers an outer surface of the pipeline and is covered by an external conducting layer.

Abstract: Methods of generating an isolated population of non-graft versus host disease (GVHD) inducing cells comprising a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation, are disclosed. Cells generated by the methods, pharmaceutical compositions and methods of treatment are also disclosed.

Abstract: Methods of using an organic framework (OF) are provided herein, including methods of using an OF comprising a repeat unit of the formula: The OFs provided herein may be used in the separation of two or more molecules from each other. In some embodiments, the molecules are propylene and propane.

Abstract: Systems and methods for image processing generate a contour for a region in an image. One example method generally includes identifying a first contour edge associated with a region having a plurality of region points, the first contour edge extending from a first region point of the plurality of region points to a second region point of the plurality of region points, identifying a second contour edge associated with the region extending from the first region point to a third region point of the plurality of region points, determining whether a contour associated with the region has fewer vertices using the second contour edge as compared to using the first contour edge, the contour comprising a concave hull, and generating the contour based on the determination.

Abstract: The present disclosure is directed to method of diagnosing and treating heart disease using antibodies that bind to Cofilin, A? and/or Tau.

Abstract: Provided herein are antibodies binding to Coronavirus S protein and the uses of the antibodies in detecting and treating Coronavirus infection, such as COVID-19.

Abstract: A Cell Migration Assay Plates (CMAP) assembly for high throughput microfluidic migration assays and method of manufacturing thereof are provided. The CMAP assembly includes a top plate having a plurality of wells aligned with a bottom plate having a plurality of troughs. Each of the plurality of wells is defined at least in part by first and second reservoirs and a divisional wall extending between the reservoirs. The bottom plate is secured to the top plate to form a plurality of micro-channels, such that each one of the plurality of micro-channels is defined by a portion of one of the divisional walls and a portion of a corresponding one of the plurality of troughs. The plurality of micro-channels enable communication between the reservoirs and visualization of cells migrating through the micro-channels. In this manner, migration of cells through the micro-channels can be visualized for testing and screening applications.

Abstract: The present invention relates to compounds which may be useful as inhibitors of PTPN11 for the treatment or prevention of cancer and other PTP-mediated diseases. Disclosed herein are new compounds and compounds based on pyrazolopyrazines and their application as pharmaceuticals for the treatment of disease.

Abstract: The present application generally relates to the development of a universal influenza vaccine, or production of antibodies, capable of providing broad protection against various strains of the flu, using an informational spectrum method (ISM) to identify the common structural characteristics of influenza antigens.

Abstract: The present disclosure provides compounds that may be used as ligands in metal-catalyzed reactions, in particular 3,3?-bisilyl biaryl phosphoramidite compounds and processes for preparing the same.

Abstract: Provided herein are compositions and methods for reducing expression of C9orf72 transcripts in cells containing expanded intronic GGGGCC regions, including those in subjects having or at risk of developing amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

Abstract: A system and method estimate the fault severity index and consequently the number of shorted turns in permanent magnet motors (PMSM) with inter turn short circuit fault (ITSC). In this method, the machine is excited with DC current at stand still conditions to obtain the winding resistance seen by the d-axis of the machine. The estimated d-axis resistance contains useful information pertaining to the fault severity index, and is used to extract the fault severity index and the number of shorted turns in the faulty motor. The method enables the estimation of fault severity index without complex modeling with different machine prototypes, or FEA models to analyze the relationship between machine currents and short circuit current. To enhance the accuracy of the estimation method, this disclosure addresses issues associated with inverter non-linearity effects such as distortion voltage due to dead time effects and voltage drops across the switching devices.

Abstract: The present invention relates to adenosine receptor agonist compounds and methods of use thereof for treatment of certain disorders and conditions, for example an addiction or compulsive disorder. Exemplary compounds for use in disclosed methods include: and pharmaceutically acceptable salts thereof.

Abstract: Endolysosomal targeting conjugates that are engineered to deliver cargo molecules such as cytotoxic drugs or imaging labels with improved efficiency to late endosomes and/or lysosomes in target cells such as tumor cells are described. The endolysosomal targeting conjugate includes a targeting component and a cargo component. The targeting component is configured to bind to a cell surface molecule of a target cell and the cargo component includes a cargo molecule. The targeting component and the cargo component may be fused by a covalent bond or associated by a non-covalent bond. The targeting component may bind to the cell surface molecule or the cargo component with higher affinity in the extracellular space than in an endolysosomal compartment of the target cell.

Abstract: Aspects of the present disclosure relate to methods for producing formative pluripotent stem cells (PSCs) by culturing cells in a medium that comprises a fibroblast growth factor (FGF) activator, a transforming growth factor beta (TGF-?) activator, and a WNT activator. Also provided are in vitro culture systems for producing the formative pluripotent stem cells.

Abstract: Aspects of the disclosure relate to MUC18-binding proteins. Embodiments include methods for treating one or more conditions, for example cancer, using a MUC18-binding protein. In some embodiments, the disclosed methods and compositions involve one or more antibodies that are capable of binding MUC18.

Abstract: The present techniques may provide improved processing and functionality of performance of the 128-bit AES Algorithm, which may provide improved power consumption. For example, in an embodiment, an encryption and decryption apparatus may comprise memory storing a current state matrix of an encryption or decryption process and a plurality of multiplexers configured to receive from the memory current elements of the state matrix stored in the memory, perform a cyclic shift on the received elements of the state matrix, and transmit the shifted elements to the memory for storage as a new state matrix.

Abstract: Disclosed are devices for improving viability of isolated islets or ?-cells and stimulating insulin production from isolated islets or ?-cells and uses thereof for treating type 1 diabetes.

Abstract: Recombinant Norovirus Virus-Like Particles (VLPs) formed from recombinant Norovirus VP1 proteins, and methods of their use and production are disclosed. In several embodiments, the Recombinant Norovirus VLPs can be used to generate an immune response to Norovirus VP1 protein in a subject. In additional embodiments, an effective amount of the recombinant Norovirus VLPs can be administered to a subject in a method of inhibiting a Norovirus infection.

Abstract: Devices and methods for nasal administration of a pharmaceutical composition. In certain embodiments, the devices comprises a reservoir, a conduit in fluid communication with the reservoir, and an anatomic positioning device configured to position the conduit in a nasal cavity of a user. Particular embodiments include an actuator configured to transfer the pharmaceutical composition from the reservoir to the conduit and emit the pharmaceutical composition from the conduit.