Abstract: A procedure is disclosed for automatically constructing wrappers for performing information-extraction from sites such as Internet resources that display relevant information, interspersed with extraneous text fragments, such as HTML formatting commands or advertisements. The procedure has three basic steps. First, a set of example pages are collected with a subroutine named GatherExamples. Gather Examples is provided with information describing how to pose example queries to the site whose wrapper is to be learned. Second, these example pages are labeled by a subroutine named LabelExamples—i.e., the information to be extracted from each example is identified for use in the third step. The LabelExamples subroutine uses a general framework for labeling pages using site-specific heuristics called recognizers, as well as allowing users to correct and modify the recognized instances. Finally, the labeled example pages are passed to a BuildWrapper subroutine, which constructs a wrapper.

Abstract: In vivo assays for selecting candidate therapeutics for inhibiting amyloidoses, such as congophilic and fibrillar .beta./A4 amyloid deposition in brain. A candidate reagent is administered to a first rat in a first infusate comprising .beta./A4 peptide and perlecan by continuous infusion into the hippocampus for at least one week. The candidate reagent is selected as a candidate therapeutic for inhibiting congophilic and fibrillar .beta./A4 amyloid deposition in brain if the first infusate diminishes congo red and thioflavin S staining indicative of amyloid deposition adjacent to the infusion site, as compared with a second rat receiving a second infusate consisting essentially of .beta./A4 peptide and perlecan.