Patents Assigned to Board of Regents of University of Nebraska
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Patent number: 11813377Abstract: Three dimensional nanofiber structures are provided and methods of production thereof.Type: GrantFiled: May 11, 2021Date of Patent: November 14, 2023Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKAInventors: Jingwei Xie, Jiang Jiang
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Patent number: 11813124Abstract: Disclosed herein are gross positioning systems for use with robotic surgical devices to provide gross positioning of the robotic surgical devices. The gross positioning systems have a base, a first arm link operably coupled to the base, a second arm link operably coupled to the first arm link, a third arm link operably coupled to the second arm link, and a slidable coupling component slidably coupled to the third arm link.Type: GrantFiled: June 13, 2022Date of Patent: November 14, 2023Assignee: Board of Regents of the University of NebraskaInventors: Mark Reichenbach, Shane Farritor
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Patent number: 11806385Abstract: The present invention provides novel biomarkers for regulatory T cells (Treg) function and Parkinson's disease.Type: GrantFiled: April 24, 2017Date of Patent: November 7, 2023Assignees: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA, THE SCRIPPS RESEARCH INSTITUTEInventors: Howard E. Gendelman, R. Lee Mosley, Gary Siuzdak, Erica Forsberg
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Patent number: 11806097Abstract: The various embodiments disclosed herein relate to improved robotic surgical systems, including robotic surgical devices having improved arm components and/or biometric sensors, contact detection systems for robotic surgical devices, gross positioning systems and devices for use in robotic surgical systems, and improved external controllers and consoles.Type: GrantFiled: March 30, 2020Date of Patent: November 7, 2023Assignee: Board of Regents of the University of NebraskaInventors: Shane Farritor, Thomas Frederick, Joe Bartels, Eric Markvicka, Jack Mondry
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Patent number: 11806040Abstract: An intravascular cutting device described herein uses high-pressure water, saline, or other fluid to cut tissue and other materials including but not limited to calcified tissue, stents, stent grafts, and other devices. In some embodiments, the cutting device includes a working end that has a nozzle with a hole to allow the release of a high-pressure fluid jet. Opposite of the nozzle is a catch plate or deflector anvil that prevents the fluid jet from cutting healthy tissue. The device user will place the item to be cut between the nozzle and catch plate and then advance the device along the item to be cut as the fluid jet is activated, thus cutting the object as it advances.Type: GrantFiled: September 8, 2021Date of Patent: November 7, 2023Assignee: Board of Regents of the University of NebraskaInventors: Jason N. MacTaggart, Alexey Kamenskiy, Paul Deegan
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Patent number: 11779517Abstract: A medication bottle includes an outer container wall, an inner container wall and a fluid, such as an aversive liquid, located between the walls. In another aspect, the fluid is located within separate compartments or channels located between the walls where the walls contact or are secured to each other. A further aspect provides a removeable cap including multiple sensors, at least one of which is a biometric sensor.Type: GrantFiled: September 21, 2021Date of Patent: October 10, 2023Assignees: Board of Trustees of Michigan State University, Board of Regents of the University of NebraskaInventors: Bahar Aliakbarian, Muhammad Rabnawaz, Susan E. Selke, Krystal Cheng, Arun Ross, Austin Cozzo, Anurag Chowdhury, Ali Tamayol, Carina Russell, Prem Chahal
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Patent number: 11764786Abstract: A magneto-electric (ME) majority gate device includes a conducting device and a plurality of ME transistors coupled to the conducting device. In one implementation, the plurality of ME transistors include a ME AND gate device with downward interface polarization, a ME-transmission gate device with downward interface polarization, and a ME-XNOR gate device. In another implementation, the plurality of ME transistors is five single-input ME-FETs.Type: GrantFiled: May 29, 2022Date of Patent: September 19, 2023Assignees: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, INTEL CORPORATIONInventors: Nishtha Sharma Gaul, Andrew Marshall, Peter A. Dowben, Dmitri E. Nikonov
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Patent number: 11752221Abstract: Disclosed are methods, compositions, reagents, systems, and kits to prepare nitroxide-functionalized brush-arm star polymer organic radical contrast agent (BASP-ORCA) as well as compositions and uses thereof. Various embodiments show that BASP-ORCA display unprecedented per-nitroxide and per-molecule transverse relaxivities for organic radical contrast agents, exceptional stability, high water solubility, low in vitro and in vivo toxicity, and long blood compartment half-life. These materials have the potential to be adopted for tumor imaging using clinical high-field 1H MRI techniques.Type: GrantFiled: June 29, 2018Date of Patent: September 12, 2023Assignees: Massachusetts Institute of Technology, Board of Regents of the University of NebraskaInventors: Jeremiah A. Johnson, Hung Vanthanh Nguyen, Andrzej Rajca
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Patent number: 11757449Abstract: A magneto-electric (ME) XNOR logic gate device includes a conducting device; and a ME-FET coupled to the conducting device. The ME-FET can be formed of a split gate; a first gate terminal coupled to a first portion of the split gate for receiving a first input signal; a second gate terminal coupled to a second portion of the split gate for receiving a second input signal; a source terminal coupled to a ground line; and a drain terminal coupled to the conducting device.Type: GrantFiled: May 29, 2022Date of Patent: September 12, 2023Assignees: BOARD OF REGENT'S OF THE UNIVERSITY OF NEBRASKA, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, INTEL CORPORATIONInventors: Nishtha Sharma Gaul, Andrew Marshall, Peter A. Dowben, Dmitri E. Nikonov
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Publication number: 20230277443Abstract: There is disclosed a method for administration of a formulation of resiniferatoxin (RTX) to provide cardiac sympathetic afferent denervation when applied in an amount and concentration sufficient to chemically denervate vanilloid 1 receptor (TRPV1)-expressing CSAR (cardiac sympathetic afferent reflex) afferents. There is further disclosed a method for treating heart failure or hypertension and its related indications selected from the group consisting of increased sympatho-excitation, cardiac hypertrophy, increased left ventricular end diastolic pressure (LVEDP), lung edema, and combinations thereof, comprising administering an effective amount of RTX directly to a tissue site selected from the group consisting of epicardium, a T1-T4 dorsal root ganglion and intrathecally to the T1-T4 region of the spinal column.Type: ApplicationFiled: May 16, 2023Publication date: September 7, 2023Applicant: Board of Regents of the University of NebraskaInventors: Irving H. Zucker, Hanjun Wang
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Publication number: 20230271002Abstract: A hydrogel ionic circuit (HIC) electrode configured for electrical stimulation and/or drug therapy (e.g., iontophoresis) is disclosed. The HIC electrode includes a chamber containing a salt solution. The chamber is at least partially bound by a hydrogel membrane that defines a barrier for the salt solution. The HIC electrode further includes an electrode configured to apply an electrical current to the chamber to induce an ion current in the salt solution, wherein the hydrogel membrane is ionically conductive and configured to transmit the ion current.Type: ApplicationFiled: July 29, 2021Publication date: August 31, 2023Applicant: Board of Regents of the University of NebraskaInventors: Siwei ZHAO, Fan ZHAO
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Patent number: 11738116Abstract: Expanded, nanofiber structures comprising electrospun nanofibers, a plurality of holes, and, optionally, cells are provided. Methods of making the nanofiber structures as well as methods of use thereof, particularly for wound healing, are also provided.Type: GrantFiled: June 8, 2018Date of Patent: August 29, 2023Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKAInventors: Jingwei Xie, Shixuan Chen, Mark Carlson
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Patent number: 11732273Abstract: Disclosed are methods and compositions for in situ germline genome engineering. The disclosed methods and compositions may be utilized for germline genome engineering in a subject having a reproductive organ containing a fertilized zygote, via: (i) isolating or obtaining the reproductive organ from the subject after a time period following insemination of the subject; (ii) introducing a reagent composition into the reproductive organ, the reagent composition comprising a nuclease system and/or an exogeneous polynucleotide; and (iii) electroporating the reproductive organ.Type: GrantFiled: February 24, 2020Date of Patent: August 22, 2023Assignees: Board of Regents of the University of Nebraska, Tokai University Educational SystemInventors: Channabasavaiah Gurumurthy, Masato Ohtsuka, Masahiro Sato
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Publication number: 20230240544Abstract: An apparatus for assessing user frailty is disclosed. In embodiments, the apparatus includes a housing that defines (or is defined by) a body and a handle coupled to the body. The apparatus includes a force sensor at least partially disposed within the handle. The apparatus further includes an inertial sensor at least partially disposed within the housing. The apparatus may further include a user interface device disposed within a cavity of the body. The user interface device may be coupled to the force sensor and the inertial sensor via one or more signal paths. In embodiments, the user interface device includes a controller with a touchscreen coupled to the controller.Type: ApplicationFiled: February 8, 2023Publication date: August 3, 2023Applicant: Board of Regents of the University of NebraskaInventor: Jason M. Johanning
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Patent number: 11701216Abstract: There is described an arteriovenous fistula stent, having a tubular body comprising a series of sinusoidal shaped struts along the length of the tubular body. A plurality of curvilinear connectors extend between and are attached to adjacent struts wherein a first end of a connector is attached to a distal face of a proximal strut apex and a second end of a connector is attached to a proximal face of a distal strut apex. A pair of unconnected strut apexes are between pairs of connected apexes. When the tubular body is in a stowed configuration a proximal aperture and a distal aperture are circular and when the tubular body is in a deployed configuration the distal aperture is oblong or ovoid. There is also described a method for inserting a stent for use in creation of an arteriovenous fistula by identifying a candidate artery and a candidate vein and dissecting the candidate vein. Next, inserting a stent into the vein and creating a breach in the candidate artery at a desired angle and location.Type: GrantFiled: August 13, 2020Date of Patent: July 18, 2023Assignee: Board of Regents of the University of NebraskaInventor: Marius C. Florescu
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Publication number: 20230211098Abstract: An infectious aerosol capture mask (IACM) includes a face tent coupled to a suction tube adapter. The face tent includes a proximal opening configured to be disposed over the mouth and nose of a patient. The face tent further includes a distal opening with a smaller diameter than the proximal opening. A coupler is configured to secure the suction tube adapter to the distal opening of the face tent. The suction tube adapter includes a suction port configured to be coupled to a suction tube for active capture of infectious aerosol and left unconnected for passive capture of infectious aerosol. A viral filter is disposed between the suction port and the face tent to capture infectious aerosols expelled by the patient. The IACM further includes one or more one-way valves that are configured to permit airflow into the face tent.Type: ApplicationFiled: June 14, 2021Publication date: July 6, 2023Applicant: Board of Regents of the University of NebraskaInventors: Steven LISCO, Nicholas MARKIN
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Publication number: 20230200909Abstract: A number of improvements are provided relating to computer aided surgery. The improvement relates to both the methods used during computer aided surgery and the devices used during such procedures. Some of the improvement relate to controlling the selection of which data to display during a procedure and/or how the data is displayed to aid the surgeon. Other improvements relate to the structure of the tools used during a procedure and how the tools can be controlled automatically to improve the efficiency of the procedure. Still other improvements relate to methods of providing feedback during a procedure to improve either the efficiency or quality, or both, for a procedure.Type: ApplicationFiled: December 23, 2022Publication date: June 29, 2023Applicant: Board of Regents of the University of NebraskaInventors: Hani Haider, Osvaldo Andres Barrera
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Patent number: 11679075Abstract: There is disclosed a method for administration of a formulation of resiniferatoxin (RTX) to provide cardiac sympathetic afferent denervation when applied in an amount and concentration sufficient to chemically denervate vanilloid 1 receptor (TRPV1)-expressing CSAR (cardiac sympathetic afferent reflex) afferents. There is further disclosed a method for treating heart failure or hypertension and its related indications selected from the group consisting of increased sympatho-excitation, cardiac hypertrophy, increased left ventricular end diastolic pressure (LVEDP), lung edema, and combinations thereof, comprising administering an effective amount of RTX directly to a tissue site selected from the group consisting of epicardium, a T1-T4 dorsal root ganglion and intrathecally to the T1-T4 region of the spinal column.Type: GrantFiled: June 24, 2020Date of Patent: June 20, 2023Assignee: Board of Regents of the University of NebraskaInventors: Irving H. Zucker, Hanjun Wang
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Patent number: 11661411Abstract: Provided herein are compounds having a structure of formula (I) and methods of using the disclosed compounds to inhibit IKK? activity.Type: GrantFiled: December 3, 2018Date of Patent: May 30, 2023Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKAInventor: Amarnath Natarajan
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Patent number: 11658663Abstract: A magneto-electric (ME) inverter includes two anti-ferromagnetic spin orbit read (AFSOR) circuit elements, each AFSOR circuit element has a CMOS inverter; and an AFSOR device with a ME base layer; a semiconductor channel layer on the ME base layer and comprising a source terminal and a drain terminal, where the source terminal is coupled to an output of the CMOS inverter; and a gate electrode on the semiconductor channel layer. The gate electrode of a second AFSOR device of the two AFSOR circuit elements is coupled to the drain terminal of a first AFSOR device of the two AFSOR circuit elements.Type: GrantFiled: May 29, 2022Date of Patent: May 23, 2023Assignees: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA, INTEL CORPORATION, Board OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Nishtha Sharma Gaul, Andrew Marshall, Peter A. Dowben, Dmitri E. Nikonov