Patents Assigned to Board of Regents, The Texas University System
  • Molecules with extended half-lives, compositions and uses thereof
    Patent number: 8475792
    Abstract: The present invention provides molecules, including IgGs, non-IgG immunoglobulins, proteins and non-protein agents, that have increased in vivo half-lives due to the presence of an IgG constant domain, or a portion thereof that binds the FcRn, having one or more amino acid modifications that increase the affinity of the constant domain or fragment for FcRn. Such proteins and molecules with increased half-lives have the advantage that smaller amounts and or less frequent dosing is required in the therapeutic, prophylactic or diagnostic use of such molecules.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: July 2, 2013
    Assignees: MedImmune, LLC, Board of Regents, The Texas University System
    Inventors: William Dall'Acqua, Leslie S. Johnson, Elizabeth Sally Ward Ober
  • METHOD AND APPARATUS TO IDENTIFY VULNERABLE PLAQUES WITH THERMAL WAVE IMAGING OF HEATED NANOPARTICLES
    Publication number: 20120150031
    Abstract: Provided herein are systems, methods, and compositions for the thermal imaging of cells with nanoparticles.
    Type: Application
    Filed: December 6, 2011
    Publication date: June 14, 2012
    Applicants: Board of Regents, The Texas University System, Volcano Corporation
    Inventors: Paul Castella, Jihoon Kim
  • METHOD AND APPARATUS TO IDENTIFY VULNERABLE PLAQUES WITH THERMAL WAVE IMAGING OF HEATED NANOPARTICLES
    Publication number: 20080095714
    Abstract: Provided herein are systems, methods, and compositions for the thermal imaging of cells with nanoparticles.
    Type: Application
    Filed: October 22, 2007
    Publication date: April 24, 2008
    Applicants: CardioSpectra, Inc., Board of Regents, The Texas University System
    Inventors: Paul Castella, Jihoon Kim